Nucleotídeos
Os nucleotídeos são compostos orgânicos que servem como building blocks dos ácidos nucleicos, essenciais para a formação de DNA e RNA. Cada nucleotídeo é composto por uma base nitrogenada, uma molécula de açúcar e um ou mais grupos fosfato. Esses nucleotídeos se unem para formar longas cadeias, criando o material genético que carrega e transmite informações genéticas em todos os organismos vivos. Nesta seção, você encontrará uma ampla variedade de nucleotídeos cruciais para pesquisas em genética, biologia molecular e bioquímica. Eles são fundamentais para estudar processos genéticos, sintetizar ácidos nucleicos e desenvolver ferramentas diagnósticas e terapêuticas. Na CymitQuimica, oferecemos nucleotídeos de alta qualidade para apoiar suas pesquisas científicas e aplicações, garantindo precisão e confiabilidade em seus experimentos.
Subcategorias de "Nucleotídeos"
Foram encontrados 2637 produtos de "Nucleotídeos"
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1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)thymine
CAS:1-(3`,5`-Di-O-benzoyl-2`-deoxy-2`-fluoro-beta-L-arabinofuranosyl)thymine is a nucleoside analog with modifications that influence its biological activity. It contains a thymine base and 3',5'-Di-O-benzoyl groups that protect hydroxyl functionalities during chemical synthesis. This molecule also has the sugar 2'-Deoxy-2'-fluoro-β-L-arabinofuranose made up of an L-arabinose configuration and a 2'-Fluoro substitution, the latter of which enhances stability and resistance to enzymatic degradation.Fórmula:C24H21FN2O7Pureza:Min. 95%Peso molecular:468.43 g/molNADPH 4Na - min 95%
CAS:Beta-nicotinamide adenine dinucleotide phosphate sodium salt (NADPH) is a coenzyme that mediates various biological processes. It’s a regenerating electron donor in cellular antioxidation systems and a regulator of energy metabolism and mitochondrial functions. It mediates calcium homeostasis via the generation of cyclic ADP-ribose and modulates several key factors in cell death such as mitochondrial permeability transition and poly(ADP-ribose) polymerase-1 (PARP1).Fórmula:C21H26N7O17P3·4NaPureza:Min. 95 Area-%Cor e Forma:White PowderPeso molecular:833.35 g/mol5'-O-Levulinoylthymidine
CAS:5'-O-Levulinoylthymidine is a novel nucleoside analog that inhibits viral proliferation by inhibiting viral RNA polymerase. This drug is also an activator of ribonucleotide reductases, which are enzymes that synthesize deoxyribonucleotides from ribonucleotides. 5'-O-Levulinoylthymidine has been shown to inhibit the growth of cancer cells in vitro and in vivo. It has also been shown to be effective against HIV-1 infection in vitro.Fórmula:C15H20N2O7Pureza:Min. 95%Cor e Forma:White Off-White PowderPeso molecular:340.33 g/mol3'-Deoxy-3'-fluoroguanosine
CAS:3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that is used for the treatment of viral hepatitis, cancer, and other diseases. 3'-Deoxy-3'-fluoroguanosine inhibits the replication of RNA by binding to the replicon. It binds to the RNA polymerase in a pharmacophore-based manner and inhibits its activity. When combined with other drugs, it has been shown to increase their efficacy. The combination of 3'-deoxy-3'-fluoroguanosine with interferon alpha 2b for the treatment of Hepatitis B has been shown to be more effective than either drug alone. The inhibition of cellular growth by 3'-deoxy-3'-fluoroguanosine may be due to its ability to inhibit rna synthesis.Fórmula:C10H12N5O4FPureza:Min. 95%Cor e Forma:White PowderPeso molecular:285.23 g/molGuanosine 5'-monophosphate
CAS:Guanosine 5'-monophosphate, also known as GMP, is a ribonucleoside monophosphate that becomes incorporated into RNAs when phosphorylated to GTP.Fórmula:C10H14N5O8PPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:363.22 g/mol2'-Deoxy-5-iodocytidine
CAS:Anti-viral agent; iodinated analog of deoxycytidineFórmula:C9H12IN3O4Pureza:Min. 98 Area-%Cor e Forma:White Off-White PowderPeso molecular:353.12 g/mol5-Fluorouridine-5'-O-b-D-galactopyranoside
CAS:5-Fluorouridine-5'-O-b-D-galactopyranoside is a nucleoside that can be used as an activator to synthesize ribonucleosides and deoxyribonucleosides. This product is also an anticancer agent, as it inhibits cell proliferation by inactivating the enzyme DNA polymerase. It is highly purified, with a purity of 99%.Fórmula:C15H21FN2O11Pureza:Min. 98 Area-%Cor e Forma:Off-White PowderPeso molecular:424.33 g/mol2'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine is a modified nucleoside that is categorized as a mismatched nucleotide. It is found in RNA, where it replaces uridine and acts as a mismatch base. 2'-O-Methyl-2-thiouridine has been shown to stabilize duplex DNA against thermal denaturation by forming triplexes with complementary sequences. It also stabilizes dsDNA against hydrolysis by the enzyme ribonuclease H (RNase H) and has been used in the design of antisense therapeutics. Thermophilic bacteria use this molecule to synthesize their own thymine nucleotides, which are structurally similar to 2'-O-methyl-2-thiouridine. This modification prevents mismatches in their own dna and helps protect them from heat stress. The thermodynamic stability of this molecule has been calculated using an algorithm that takes into account the hybridization free energy, enthalpy change, entropyFórmula:C10H14N2O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:274.29 g/molTetrahydrouridine
CAS:Tetrahydrouridine is a pyrimidine nucleoside that has been shown to have inhibitory properties in clinical pathology. Tetrahydrouridine is a natural product derived from the amino acid histidine and is found in the cells of many living organisms. It is believed that tetrahydrouridine may be useful as an adjuvant to radiation therapy, and it has been shown to reduce the toxicity of chemotherapy drugs, such as decitabine and Ara-C. Tetrahydrouridine inhibits enzymes involved in DNA methylation, which can lead to cancer cell death.br> Tetrahydrouridine also has inhibitory effects on enzymes that produce cytidine from uracil, which can help prevent the formation of cancerous cells.br> Tetrahydrouridine inhibits deaminase activity, which produces uracil from cytosine. This inhibition prevents the production of uracil-cytosineFórmula:C9H16N2O6Pureza:Min. 95%Cor e Forma:White Off-White PowderPeso molecular:248.23 g/mol2'-O-Propargylguanosine
CAS:2'-O-Propargylguanosine is a monophosphate nucleoside that is synthesized from Ribonucleosides. It has been shown to have antiviral and anticancer properties. 2'-O-Propargylguanosine has shown to be an activator of the transcription factor NF-κB and to induce apoptosis in various cancer cell lines. This drug inhibits viral replication by inhibiting DNA polymerase, thereby preventing RNA synthesis.
Fórmula:C13H15N5O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:321.29 g/mol2',3',5'-Tri-O-acetyl-2-fluoroadenosine
CAS:2',3',5'-Tri-O-acetyl-2-fluoroadenosine is nucleoside analog of adenosine for use in research. The addition of a fluorine to an adenosine can change adenosine's properties such as its hydrogen bonding ability and how it interacts with water and other biological molecules. It can also increase the stability of adenosine and increase its half-life in biological systems.
Fórmula:C16H18FN5O7Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:411.34 g/molN2-Isobutyrylguanosine
CAS:N2-Isobutyrylguanosine is a synthetic nucleoside analog. It is activated by the enzyme thymidine kinase and inhibits the synthesis of RNA and DNA, which leads to cell death. N2-Isobutyrylguanosine has been shown to be an effective inhibitor of epidermal growth factor receptor (EGFR) in mammalian cells. This drug has also been shown to inhibit insulin-like growth factor I and phosphorothioate monomers. N2-Isobutyrylguanosine inhibits the synthesis of fatty acids, leading to a decrease in lipid content in cells.Fórmula:C14H19N5O6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:353.33 g/mol5-Hydroxyuridine
CAS:5-Hydroxyduridine is a nucleoside that is naturally found in the human body. It can be synthesized from uridine by oxidation of the 5-hydroxyl group to the corresponding aldehyde. It has been shown to have genotoxic effects in vitro and in prostate cancer cells. 5-Hydroxyduridine has also been shown to inhibit sugar transport, which may be due to its ability to form hydrogen bonds with glycosidic bonds. It has been reported that 5-hydroxyduridine causes acid formation and hydroxylation of cardiac lipids.Fórmula:C9H12N2O7Pureza:Min. 96 Area-%Cor e Forma:White Off-White PowderPeso molecular:260.2 g/mol7-Deaza-2',3'-dideoxyadenosine
CAS:7-Deaza-2',3'-dideoxyadenosine (7DDAD) is a nucleoside analogue that has been used as an immunodeficiency agent. This drug inhibits the replication of the human immunodeficiency virus (HIV). 7DDAD is a prodrug that is converted to adenosine after it enters the cell, and this conversion prevents DNA synthesis. The effective dose of 7DDAD is 50 mg/kg in rats, but this dose may vary depending on the technique used. 7DDAD has been shown to be effective in vitro against HIV-1 and HIV-2 isolates, and it can also be used to treat cytomegalovirus infections. In addition, 7DDAD has been shown to inhibit the growth of various types of cancer cells in vitro.Fórmula:C11H14N4O2Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:234.26 g/mol2'-O-Methyladenosine-5'-triphosphate sodium salt - 100mM aqueous solution
CAS:2'-O-Methyladenosine-5'-triphosphate sodium salt is a novel nucleoside phosphoramidite. It is an activator and it can be used in the synthesis of DNA and RNA. The compound has antiviral properties and has been shown to inhibit DNA replication, protein synthesis, and RNA transcription. The compound also inhibits the growth of cancer cells by inducing apoptosis.Fórmula:C11H18N5O13P3·xNaPureza:Min. 95%Cor e Forma:PowderPeso molecular:521.21 g/molThymidine-5'-diphosphate trisodium salt
CAS:Thymidine-5'-diphosphate trisodium salt is a novel anticancer drug that is structurally modified to resemble thymidine. It has antiviral and antitumor effects and can be used as an antineoplastic agent. Thymidine-5'-diphosphate trisodium salt is a high quality, high purity ribonucleoside that can be used in the synthesis of deoxyribonucleosides and phosphoramidites. This drug has shown activity against various types of cancer cells and is being investigated for its potential use in the treatment of leukemia.
Fórmula:C10H13N2Na3O11P2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:468.13 g/mol3'-Deoxy-3'-fluoroadenosine
CAS:3'-Deoxy-3'-fluoroadenosine is a potent inhibitor of the phosphodiesterase enzyme, which is an important component of many different cellular processes. It has been shown to inhibit the activity of phosphodiesterase in cell culture and in serum alanine. 3'-Deoxy-3'-fluoroadenosine also inhibits the synthesis of uridine triphosphate, which is required for DNA replication and protein synthesis. The acid complex form has potent inhibition properties against viruses such as alphaviruses, and it also inhibits transport of nucleic acids into cells. 3'-Deoxy-3'-fluoroadenosine can act as an analog to adenosine and may be used to treat viral infections such as HIV or herpes simplex virus.Fórmula:C10H12FN5O3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:269.23 g/mol2',3',5'-Tri-O-acetyluridine
CAS:2',3',5'-Tri-O-acetyluridine is a uridine derivative with potential for use in organic synthesis such as the preparation of modified nucleosides, nucleotides, and RNA analogs.Fórmula:C15H18N2O9Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:370.31 g/mol2'-Deoxy-5-iodouridine - EP
CAS:2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM. 2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.Fórmula:C9H11IN2O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:354.1 g/mol2',3'-Dideoxy-5-iodocytidine
CAS:2',3'-Dideoxy-5-iodocytidine is a modified nucleoside analog based on cytidine, one of the four standard nucleosides found in DNA and RNA. It has been chemically altered to interfere with DNA or RNA synthesis, making it potentially useful as an antiviral or anticancer agent.
Fórmula:C9H12N3IO3Pureza:Min. 95%Peso molecular:337.11 g/mol
