Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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2-(3-Chloro-thiophen-2-yl)-1H-benzoimidazole-5-carboxylic acid
CAS:Cor e Forma:SolidPeso molecular:278.70999145507813-(4-Bromo-pyrazol-1-yl)-propionic acid
CAS:Fórmula:C6H7BrN2O2Cor e Forma:SolidPeso molecular:219.0382,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride
CAS:Pureza:98%Peso molecular:286.6700134277344rac 8-Hydroxy Efavirenz
CAS:Produto ControladoFórmula:C14H9ClF3NO3Cor e Forma:NeatPeso molecular:331.67N-(4-Pyridin-2-yl-thiazol-2-yl)benzene-1,4-diamine
CAS:Cor e Forma:SolidPeso molecular:268.3399963378906N-(2-Aminoethyl)morpholine
CAS:Fórmula:C6H14N2OPureza:98%Cor e Forma:Solidified mass or fragmentsPeso molecular:130.191N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine
CAS:Pureza:98+%Peso molecular:458.8500061035156Methyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate hydrochloride
CAS:Pureza:97%Peso molecular:348.22000122070316-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile
CAS:Pureza:98%Peso molecular:445.91000366210941-(1,3-Dimethyl-1H-pyrazol-4-yl)-4,4,4-trifluoro-butane-1,3-dione
CAS:Fórmula:C9H9F3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:234.178(2S,2'S)-1,1'-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile
CAS:Fórmula:C24H33N5O3Cor e Forma:Off-WhitePeso molecular:439.55Safinamide Mesylate
CAS:Produto Controlado<p>Applications Safinamide mesylate is a potent and selective MAO-B inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C17H19FN2O2·CH4O3SCor e Forma:White To Off-WhitePeso molecular:398.453,6-Bis(5-bromothiophen-2-yl)-2,5-dioctylpyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
CAS:Pureza:95%Peso molecular:682.57000732421882-(4-Chlorophenoxy)aniline
CAS:Produto Controlado<p>Applications Amoxapine impurity.<br>References Matsuo, M., et al.: Chem. Pharma. Bull., 33, 4409 (1985),<br></p>Fórmula:C12H10ClNOCor e Forma:NeatPeso molecular:219.67(2R,3S)-rel-Nadolol-de(N-tert-butyl)methoxy
<p>Impurity Nadolol EP Impurity B<br>Stability Hygroscopic<br>Applications (2R,3S)-rel-Nadolol-de(N-tert-butyl)methoxy is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Fórmula:C14H20O5Cor e Forma:NeatPeso molecular:268.30Haloperidol-d4
CAS:Produto Controlado<p>Applications Antidyskinetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Fórmula:C212H4H19ClFNO2Cor e Forma:WhitePeso molecular:379.89Linagliptin Acetamide
CAS:Produto Controlado<p>Impurity Linagliptin N-Acetyl Impurity<br>Applications Linagliptin Acetamide is an impurity of linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Fórmula:C27H30N8O3Cor e Forma:NeatPeso molecular:514.58rac Ramelteon-d3
CAS:Produto Controlado<p>Applications Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic.<br>References Yukuhiro, N., et al.: Brain Res., 59, 1027 (2004), Cajochen, C., et al.: Curr. Opin. Invest. Drugs, 6, 114 (2005), Kato, K., et al.: Neuropharmacology, 48, 301 (2005),<br></p>Fórmula:C16H18D3NO2Cor e Forma:NeatPeso molecular:262.361?-Hydroxy Bufuralol-d9 (Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.<br>References Boobis, A.R., et al.: Biochem. Pharmacol., 34, 65 (1985), Yamazaki, H., et al.: Mol. Pharmacol., 46, 568 (1994), Mast, N., et al.: Biochem., 42, 14284 (2003),<br></p>Fórmula:C16H14D9NO3Cor e Forma:White To YellowPeso molecular:286.41N-Benzyl Carvedilol
CAS:Produto Controlado<p>Impurity Carvedilol EP Impurity C; Carvedilol Impurity C; Carvedilol USP C<br>Applications N-Benzyl Carvedilol (Carvedilol EP Impurity C) is an impurity of Carvedilol (C184625) and a degradation product in Carvedilol tablets.<br>References Karle, C., et al.: Cardiovasc. Res., 49, 361 (2001), Chen, J., et al.: Acta Cardiol. Sin., 19, 93 (2003), Xiang, T., et al.: Pharm. Res., 22, 1205 (2005),<br></p>Fórmula:C31H32N2O4Cor e Forma:NeatPeso molecular:496.60Gefitinib Morpholine N-oxide
CAS:Produto Controlado<p>Applications Gefitinib Morpholine N-oxide is the N-oxide derivative of Gefitinib (G304000); a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR).<br>References Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)<br></p>Fórmula:C22H24ClFN4O4Cor e Forma:White To Off-WhitePeso molecular:462.902-(3-Pyridyl)-2-oxazoline
CAS:Produto Controlado<p>Applications 2-(3-Pyridyl)-2-oxazoline is an impurity of Nicorandil (N398500). Nicorandil impurity E.<br></p>Fórmula:C8H8N2OCor e Forma:Off-White To Light YellowPeso molecular:148.16N-Benzyl Salbutamon Hydrochloride
CAS:Produto Controlado<p>Applications N-Benzyl Salbutamon Hydrochloride is an impurity of Albuterol (Salbutamol) (A514500), an β2-adrenoceptor agonist. Bronchodilator; tocolytic.<br>References 1. Collin, D. et al.: J. Med. Chem. 1970 Jul;13(4):674-80.2. Raidal, S. et al.: Vet. J. 2017 Apr;222:22-28.<br></p>Fórmula:C20H25NO3·ClHCor e Forma:NeatPeso molecular:363.882-Acetoxy-N-(2-thiazolyl)benzamide
CAS:Produto Controlado<p>Applications 2-Acetoxy-N-(2-thiazolyl)-benzamide is used in the synthesis of thiazolides as novel antiviral agents. Used in the inhibition of hepatitis C virus replication. Nitazoxanide Impurity<br>References Edwards, G. et al.: J. Med. Chem., 54, 8670 (2011);<br></p>Fórmula:C12H10N2O3SCor e Forma:Off-WhitePeso molecular:262.28Vadadustat
CAS:<p>Applications Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.<br>References Pergola, P., et al.: Kidney Int., 90, 1115 (2016);<br></p>Fórmula:C14H11ClN2O4Cor e Forma:BeigePeso molecular:306.703-Dehydroxy Salbutamol
CAS:Produto Controlado<p>Impurity Levalbuterol USP Related Compound B; Salbutamol EP Impurity C<br>Applications 3-Dehydroxy Salbutamol (Levalbuterol USP Related Compound B; Salbutamol EP Impurity C) is an isoprenaline based selective stimulants of β-adrenergic receptors in bronchial muscles.<br>References Hartley, D., et al.: Nature., 219, 5156 (1968);<br></p>Fórmula:C13H21NO2Cor e Forma:NeatPeso molecular:223.313-Ethyl-2-imine Meloxicam
CAS:Produto Controlado<p>Applications Meloxicam (M216100) impurity.<br></p>Fórmula:C16H17N3O4S2Cor e Forma:Light YellowPeso molecular:379.45Oxcarbazepine-D4 (Major)
CAS:Produto Controlado<p>Applications A labelled metabolite of Eslicarbazepine acetate, (BIA 2-093), a novel central nervous system drug. A keto derivative of Carbamazepine. Used as an anticonvulsant.Only available as a mixture of deuterated material:d-1: 1%d-2: 9%d-3: 35%d-4: 55%<br>References Dam., M., et al.: Epilepsy Res., 3, 70 (1989), Beydoun, A., et al.: Expert Opin. Pharmacother., 3, 59 (2001),<br></p>Fórmula:C152H4H8N2O2Cor e Forma:Light Orange Colour PowderPeso molecular:256.29Carisoprodol-d3
CAS:Produto Controlado<p>Applications Muscle relaxant (skeletal).<br>References Musso, D., et al.: J. Med. Chem. 46, 399 (2003), Newman, P., et al.: Eur. J. Clin. Pharm., 23, 31 (1982).<br></p>Fórmula:C122H3H21N2O4Cor e Forma:White PowderPeso molecular:263.35O-Methyl Meloxicam
CAS:<p>Applications O-Methyl Meloxicam is an impurity of Meloxicam (M216100).<br></p>Fórmula:C15H15N3O4S2Cor e Forma:NeatPeso molecular:365.43(S)-Ketamine Hydrochloride
CAS:Produto Controlado<p>Applications (S)-Ketamine is the more active enantiomer of the NMDA receptor antagonist and anesthetic agent Ketamine (K165300). Controlled Substance.<br>References Meliska, C.J. et al.: J. Pharmacol Exp. Therap., 212, 206 (1980); Smith, D.J. et al.: Neuropharmacology, 20, 391 (1981); Klockgether-Radke, A.P. et al.: Eur. J. Anaesthesiol., 22, 215 (2005);<br></p>Fórmula:C13H16ClNO·ClHCor e Forma:Off-WhitePeso molecular:274.1862Felodipine-13C4, d3
CAS:Produto Controlado<p>Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)<br></p>Fórmula:C1413C4H16D3Cl2NO4Cor e Forma:NeatPeso molecular:391.24Dipyridamole
CAS:Produto Controlado<p>Applications Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.<br>References Buchalter, M.B., et al.: Postgrad. Med. J., 66, 531 (1990), Sundaram, M., et al.: J. Biol. Chem., 273, 21519 (1998), Denis, D., et al.: Eur. J. Pharmacol., 367, 343 (1999),<br></p>Fórmula:C24H40N8O4Cor e Forma:YellowPeso molecular:504.632-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine Dihydrochloride
CAS:Produto Controlado<p>Applications 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine Dihydrochloride is an impurity of Chlorpromazine (C424750), which is used as an antiemetic; antipsychotic. 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine is also used in the synthesis of novel phenothiazine compounds with antimalarial activity.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970); Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990); Kalkanidis, M., et. al.: Biochem. Pharmacol., 63, 833 (2002)<br></p>Fórmula:C21H28ClN3S•2HClCor e Forma:NeatPeso molecular:462.914-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
CAS:Produto Controlado<p>Applications Sitagliptin intermediate.<br>References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),<br></p>Fórmula:C16H12F6N4O2Cor e Forma:NeatPeso molecular:406.28Nitrofurantoin-13C3
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A nitrofuran labelled antibiotic with low resistance potential that is rapidly metabolized by mammals. Active against both Gram-positive and Gram-negative bacteria. Nitrofurantoin is also a prooxidant that is cytotoxic due to the generation of intracellular H2O2. Antibacterial.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976), Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004),<br></p>Fórmula:C3C5H6N4O5Cor e Forma:NeatPeso molecular:241.14Apixaban-d3
CAS:Produto Controlado<p>Applications Apixaban-d3 is labelled Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Fórmula:C25H22D3N5O4Cor e Forma:White To Off-WhitePeso molecular:462.522,3-Dihydro-3,5-dihydroxy-6-methyl-4-pyrone
CAS:Produto ControladoFórmula:C6H8O4Cor e Forma:NeatPeso molecular:144.13Dehydro Levetiracetam
CAS:<p>Impurity Levetiracetam EP Impurity B<br>Stability Light Sensitive<br>Applications Dehydro Levetiracetam (Levetiracetam EP Impurity B) is an impurity of Levetiracetam (L331500) which is an (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of Piracetam (P500800). Used as an anticonvulsant.<br>References Gower, A. J., et al.: Eur. J. Pharmacol., 222, 193 (1992); Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996); Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000)<br></p>Fórmula:C8H12N2O2Cor e Forma:WhitePeso molecular:168.194-Amino-6-ethoxy-5-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]azo]-α-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-2-pyrimidineacetonitrile
CAS:<p>Applications 4-Amino-6-ethoxy-5-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]azo]-α-[[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]-2-pyrimidineacetonitrile is a levosimendan dimer impurity, which is a bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Fórmula:C30H30N12O3Cor e Forma:NeatPeso molecular:606.647-Hydroxy-N-des{[2-(2-hydroxy)ethoxy]ethyl} Quetiapine Dihydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Quetiapine.<br>References McConville, B., et al.: J. Clin. Psychiatry, 61, 252 (2000), Wong, Y., et al.: J. Clin. Psychopharmacol, 21, 89 (2001), Cooper, K., et al.: Eur. J. Clin. Pharmacol., 59, 51 (2003),<br></p>Fórmula:C17H17N3OS·2ClHCor e Forma:White To Off-WhitePeso molecular:384.32Carvedilol b-D-Glucuronide (mixture of diasteromers)
CAS:Produto Controlado<p>Applications A metabolite of Carvedilol (C184625).<br>References McGurk, K., et al.: Biochem. Pharmacol., 55, 1005 (1998), Tukey, R., et al.: Annu. Rev. Pharmacol. Toxicol., 40, 581 (2000), Bowalgaha, K., et al.: Br. J. Clin. Pharmacol., 52, 605 (2001), Richardson, T., et al.: Drug Metab. Dispos., 34, 351 (2006),<br></p>Fórmula:C30H34N2O10Cor e Forma:NeatPeso molecular:582.60Edoxaban Tosylate Monohydrate
CAS:<p>Applications Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>Fórmula:C31H38ClN7O7S2•xH2OCor e Forma:White To Off-WhitePeso molecular:720.266-Hexadecanoylamino-4-methylumbelliferyl β-D-Galactopyranoside
CAS:Fórmula:C32H49NO9Cor e Forma:NeatPeso molecular:591.734-(2-Aminophenyl)-3-morpholinone
CAS:<p>Applications 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004), Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005),<br></p>Fórmula:C10H12N2O2Cor e Forma:Off White SolidPeso molecular:192.214Nitisinone-13C6
CAS:<p>Applications Labelled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.<br>References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),<br></p>Fórmula:C813C6H10F3NO5Cor e Forma:Light Beige To BrownPeso molecular:335.18Ethyl Ethanesulfonate
CAS:Produto Controlado<p>Applications Ethyl Ethanesulfonate is used as a reactant in stereoselective Friedel-Crafts alkylation reactions. Also used in the preparation of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids.<br>References Stadler, D., Bach, T.: Chem. Asian J., 3, 272 (2008); Blesic, M., et al.: Phys. Chem. Chem. Phys., 11, 8939 (2009);<br></p>Fórmula:C4H10O3SCor e Forma:NeatPeso molecular:138.19rac 8,14-Dihydroxy Efavirenz-d4
CAS:Produto Controlado<p>Applications A labelled metabolite of Efavirenz (E425000) (secondary metabolism).<br>References Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Desta, Z., et al.: J. Pharmacol. Exp. Ther., 285, 428 (1998), Langmann, P., et al.: Eur. J. Med. Res., 7, 309 (2002), Chang, T., et al.: Drug Metab. Dispos., 31, 7 (2003),<br></p>Fórmula:C14H5D4ClF3NO4Cor e Forma:NeatPeso molecular:351.70Pibrentasvir
CAS:Produto Controlado<p>Applications Pibrentasvir (CAS# 1353900-92-1) is an antiviral used for hepatitis C virus NS3/4A protease inhibition.<br>References Ng, T. I.; et al.: Antimicrob. Agents Chemother., 62, 1 (2018).<br></p>Fórmula:C57H65F5N10O8Cor e Forma:Off-White To Light YellowPeso molecular:1113.18rac,trans-Milnacipran Hydrochloride
CAS:Produto Controlado<p>Applications rac,trans-Milnacipran Hydrochloride is an impurity of rac-Milnacipran Hydrochloride (M344600), an antidepressant and a selective norepinephrine and serotonin reuptake inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moret, C., et al.: Neuropharmacology, 24, 1211 (1985), Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989), Spencer, C.M., et al.: Drugs, 56, 405 (1998)<br></p>Fórmula:C15H23ClN2OCor e Forma:NeatPeso molecular:282.81cis-Hydroxy Praziquantel
CAS:<p>Applications The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Fórmula:C19H24N2O3Cor e Forma:NeatPeso molecular:328.40N-Ethyl-N-(4-picolyl)atropamide (>85%)
CAS:<p>Stability Light Sensitive<br>Applications N-Ethyl-N-(4-picolyl)atropamide is a major impurity of Tropicamide (T892650), a medication used to dilate the pupil.<br>References Stefanowicz, Zdzislawa, et al.: J. of Pharma. and Biomed. Analy., 49(2), 214-220 (2009)<br></p>Fórmula:C17H18N2OPureza:>85%Cor e Forma:NeatPeso molecular:266.34(1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester
CAS:Produto Controlado<p>Applications An intermediate in the preparation of cis-Tadalafil (T004520). A PDE5 inhibitor.<br>References Beghyn, T. et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007); Daugan, A. et al.: J. Med. Chem., 46, 4533 (2003);<br></p>Fórmula:C22H19ClN2O5Cor e Forma:Off White SolidPeso molecular:426.85(R)-Lansoprazole
CAS:<p>Stability Hygroscopic<br>Applications The R-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>Fórmula:C16H14F3N3O2SCor e Forma:Off White To Dark BrownPeso molecular:369.362-[[2-2(2-Amino-4-thiazolyl)acetyl]amino]-4-thiazoleacetic Acid
CAS:Produto ControladoFórmula:C10H10N4O3S2Cor e Forma:NeatPeso molecular:114.142α,α,α',5-Tetramethyl-1,3-benzenediacetonitrile
CAS:Produto ControladoFórmula:C14H16N2Cor e Forma:NeatPeso molecular:212.29Rivaroxaban
CAS:<p>Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H18ClN3O5SCor e Forma:White To BeigePeso molecular:435.884,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
CAS:<p>Applications 4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H17Cl2N3O5SCor e Forma:NeatPeso molecular:470.33Isoleucine Valsartan
CAS:<p>Applications Isoleucine Valsartan is a Valsartan (V095750) impurity. Valsartan is A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Fórmula:C25H31N5O3Cor e Forma:NeatPeso molecular:449.55Haloperidol Hydrochloride
CAS:Produto ControladoFórmula:C21H23ClFNO2·HClCor e Forma:NeatPeso molecular:412.325O-Desethyl Dapagliflozin tetraacetate)
CAS:<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>Fórmula:C27H29ClO10Cor e Forma:White To Off-WhitePeso molecular:548.973,4-Dihydro-7-(4-hydroxybutoxy)-2(1H)-quinolinone
CAS:Fórmula:C13H17NO3Cor e Forma:NeatPeso molecular:235.28Olanzapine 4'-N-Glucuronide
CAS:Produto ControladoFórmula:C23H28N4O6SCor e Forma:NeatPeso molecular:488.557Dehydro Felodipine Ester Lactone
CAS:Produto Controlado<p>Applications A metabolite of Felodipine (F232375).<br>References Wang, S.X. et al.: J. Pharmacol. Exp. Therap., 250, 632 (1989); Baeaernhielm, C. et al.: Drug Metab. Disp., 14, 613 (1986);<br></p>Fórmula:C17H13Cl2NO4Cor e Forma:NeatPeso molecular:366.201-Deoxy-1-(octylamino)-D-glucitol
CAS:Produto ControladoFórmula:C14H31NO5Cor e Forma:White To Off-WhitePeso molecular:293.40Rilpivirine-d6
CAS:Produto Controlado<p>Applications A labelled novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.<br>References Sun, et al.: J. Med. Chem., 41, 4648 (1998); Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001);<br></p>Fórmula:C222H6H12N6Cor e Forma:White To YellowPeso molecular:372.46Afatinib
CAS:<p>Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)<br></p>Fórmula:C24H25ClFN5O3Cor e Forma:NeatPeso molecular:485.941,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]
CAS:Fórmula:C26H34N8O5Cor e Forma:NeatPeso molecular:538.60Anastrozole Diamide
CAS:Produto Controlado<p>Impurity Anastrozole Diamide Impurity<br>Applications Anastrozole Diamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diamide Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C17H23N5O2Cor e Forma:WhitePeso molecular:329.40Topiramate
CAS:<p>Applications Used as an anticonvulsant.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987); Bialer, M.: Clin. Pharmacokinet., 24(6), 441-52 (1993)<br></p>Fórmula:C12H21NO8SCor e Forma:White To Off-WhitePeso molecular:339.36Aprepitant-d4
CAS:Produto Controlado<p>Applications Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)<br></p>Fórmula:C23H17D4F7N4O3Cor e Forma:NeatPeso molecular:538.45DL-Erythro Ritalinic Acid
CAS:Produto Controlado<p>Applications A major metabolite of Methylphenidate.<br>References Redalieu, E., et al.: Drug Metab. Dispos., 10, 708 (1982), Brewer, E., et al.: J. Pharm. Sci., 87, 395 (1998), Shah, V., et al.: Pharm. Res., 17, 1551 (2000), Tanaka, N., et al.: Anal. Chem., 73, 420 (2001),<br></p>Fórmula:C13H17NO2Cor e Forma:WhitePeso molecular:219.283-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol
CAS:Produto ControladoFórmula:C9H10F3NO2Cor e Forma:Light Beige To Light BrownPeso molecular:221.07Sulindac Acyl-β-D-Glucuronide
CAS:Produto Controlado<p>Applications Sulindac Acyl-β-D-Glucuronide is the major metabolite of the non-steroidal anti-inflammatory drug Sulindac (S699215) in plasma and urine.<br>References Hucker, H.B., et al.: Drug Metab. Dispos., 1, 721 (1973),<br></p>Fórmula:C26H25FO9SCor e Forma:NeatPeso molecular:532.534’-Hydroxyphenyl Carvedilol-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C242H3H23N2O5Cor e Forma:NeatPeso molecular:425.49Risperidone Carboxylate Impurity
CAS:Produto Controlado<p>Impurity Risperidone EP Impurity F<br>Applications Risperidone Carboxylate Impurity (Risperidone EP Impurity F) is a Risperidone (R525000) impurity.<br></p>Fórmula:C24H27FN4O4Cor e Forma:NeatPeso molecular:454.49
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