Flavonoides e Polifenóis

<p>Applications 2,4,6-Trichlorophenol is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.<br>References Nunes, C., et al.: J. Env. Biol., 29, 733 (2008), Carucci, A., et al.: Water Sci. Technol., 58, 309 (2008), Fu, W., et al.: Env., Toxicol., Chem., 28, 1372 (2009), Osborne, R., et al.: Biochem., 48, 4231 (2009), Campoy, S., et al.: Env. Microbiol., 11, 99 (2009),<br></p>

<p>Applications Naturally occurring flavonic glycoside; rhamnoglycoside of Diosmetin. Capillary protectant.<br>References Damon, M., et al.: Arzneim.-Forsch., 37, 1149 (1987), Laurent, R., et al.: Int. Angiol., 7, 39 (1988), Tajana, A., et al.: Minerva Med., 79, 387 (1988),<br></p>

<p>Applications Widely distributed in small amounts in plants. Used as an antioxidant and food preservative.<br>References Smart, M.G., et al.: Aust. J. Plant Physiol., 6, 485 (1979), Chen, C., et al.: J. Food Lipids, 2, 35,1995, Benzie, I., et al.: Anal. Biochem. 239, 70 (1996), Nardini, M., et al.: Food Chem., 79, 119 (2002), Lee, J., et al.: J. Agric. Food Chem., 52, 2647 (2004),<br></p>

<p>Applications Isotope labelled Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications (+)-Pinoresinol is a lignan found in olive oil and in other plants. This phenolic compound was reported to have antioxidant and anticancer potential.<br>References Owen, R., et al.: Eur. J. Cancer, 36, 1235 (2000); Owen, R., et al.: Food Chem. Toxicol., 38, 647 (2000);<br></p>

<p>BR1235 - 4-Hydroxybenzaldehyde</p>

<p>Stability Hygroscopic<br>Applications Eupatilin maintains anticoagulant and antiplatelet activity isolated from the Artemisia princeps Pampanini flower.<br>References Ryu, R. et al.: Prev. Nutr. Food Sci., 18, 181 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin M7 is an intestinal microbial metabolite of ellagitannins.<br>References Garcia-Villalba, R., et al.: J. Agr. Food Chem., 61, 8797 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.<br>References Kallio, T., et al.: J. Agr. Food Chem., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Food Chem., 54, 1611 (2006); Bialonska, D., et al.: J. Agr. Food Chem., 57, 10181 (2009)<br></p>

<p>Applications Matairesinol is a principle plant lignan consituent of dietary fiber.<br>References Dang, P. H., et al.: J. Nat. Prod., 80, 1876 (2017); Hu, C., et al.: Nat. Prod. Res., 31, 1358 (2017)<br></p>

<p>Applications Chrysoeriol is a methoxyflavonoid that selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. A metabolite of Luteolin (L475000).<br>References Takemura, H. et al.: J. Steroid Biochem. Mol. Biol., 118, 70 (2010); Petroianu, G. et al.: Open Med. Chem. J., 3, 1 (2009); Takemura, H. et al.: Toxicology, 274, 42 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.<br>References Ingolfsson, H., et al.: FEBS Lett., 585, 3101 (2011),<br></p>

<p>Applications A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease. Neuroprotective. Dyes and metabolites.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Applications Gallic Acid exhibits a number of cellular effects including apoptosis and inhibits the growth of calf pulmonary arterial endothelial cell (CPAEC);Also, it is a polyphenol widely found in numerous fruits and vegetables that has been reported to exert anticancer effects, including apoptosis, against cancer cell lines.<br>References Park, W. H.: Mol. Med. Rep., 16, 7805-7812 (2017); Yang, C., et al.: RSC Adv., 8, 12449-12458 (2018)<br></p>

<p>Applications Isoamyl 4-Methoxycinnamate is used in the highly protective sunscreen composition against the UVA/UVB.<br>References Cuderman, P., et al: Anal. Bioanal. Chem., 387, 1343 (2007), Zhao, X., et al.: Environ. Sci. Technol., 42, 1201 (2008), Dubrovski, P., et al.: Text Res. J., 79, 351 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Feruloylputrescine is an effector of plant root systems, influencing development of nutrient gathering root systems. Inhibition of the formation of this compound causes the development of a dominant or ‘tap’ root.<br>References Ben-Hayyim G. et al.: FEBS Lett., 4, 145 (1994);<br></p>

<p>Applications Coumarin is a pharmaceutic aid (flavor) that is found in tonka beans, levender oil, woodruff, sweet clover.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956); Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999); Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002); Yang, Z., et al.: Food Chem., 114, 289 (2009);<br></p>

<p>Applications Isochlorgenic Acid is shown to provide antioxidant and DNA-protective activities.<br>References Xu, J. et al.: J. Agri. Food Chem., 60, 11625 (2012);<br></p>