Sais e Derivados de API

<p>Applications Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);<br></p>

<p>Applications AMDP3 (4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one) acts as a cardiac troponin effecter, resulting in activation of cardiac muscle contractions. It’s an analogue to Levosimendan (L378000), positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996); Robertson, I. et al.: Biochem., 47, 7485 (2008);<br></p>

<p>Applications Pyridin-3-yl dimethylcarbamate (cas# 51581-32-9) is a useful research chemical.<br></p>

<p>Applications An intermediate in the production of Bimatoprost (B386800).<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Applications A metabolite of Trandolapril, an antihypertensive.<br>References Blankley, C.J., et al.: J. Med. Chem., 30, 992 (1987)<br></p>

<p>Stability Hygroscopic<br>Applications N1-Acetyl Triethylenetetramine is a monoacetylated metabolite of the selective CuII-chelator Triethylenetetramine (T776630).<br>References Murata, Y. et al.: Biomed. Res. Trace Elem., 4, 185 (1993): Lu, J. et al.: J. Clin. Pharmacol., 50, 647 (2010); Lu, J. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 859, 62 (2007);<br></p>

<p>Applications Nerolidol (cas# 40716-66-3) is a terpene standard found in cannabis.<br></p>

<p>Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>

<p>Applications Sodium Chlorite is used as a bleaching agent for cotton textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shenai, V.A., Pai, S.M.: Textile Dyer Printer, 3, 153 (1969)<br></p>

<p>Applications Riociguat-13C-d3 is the labelled analogue of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Applications Bisdionin C is the derivative of Theobromine (T343800), which is a metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004)<br></p>

<p>Stability Hygroscopic<br>Applications Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>

<p>Applications Edaravone D5 is the labelled compound of Edaravone(E335000). synthesized and used for relative quant. anal. of oligosaccharides by mass spectrometry (MS). Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogene<br>References Zhang, Ping, et al.: Anal. Biochem., 418, 1(2011)<br></p>

<p>Applications 5-Chloro-2-thiophenecarboxylic Acid is a metabolite of Rivaroxaban (R538000).<br>References Brickner, S., et al.: J. Med. Chem., 39, 673 (1996), Sato, K., et al.: Eur. J. Pharmacol., 347, 231 (1998), Chang, P., et al.: IDrugs, 7, 50 (2004), Weinz, C., et al.: Drug Metab. Dispos., 37, 1056 (2009)<br></p>

<p>Applications The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>

<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>

<p>Impurity Aceclofenac EP Impurity I/ Diclofenac USP Related Compound A<br>Applications A potential prodrug of Diclofenac and possible impurity during its commercial synthesis. Aceclofenac EP Impurity I; Diclofenac Impurity A<br>References Gaudiano, M.C., et al.: J. Pharm. Biomed. Anal., 32, 151 (2003), De Castro, W.V., et al.: Drug Develop. Ind. Pharm., 32, 1103 (2006),<br></p>

<p>Applications Hexadecyltrimethylammonium Bromide (CTAB) is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178<br></p>

<p>Applications Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.<br>References Rhee, D.J., et al.: Clinic. Ophthalmol., 2, 313 (2008), Hernandez, M., et al.: Exp. Eye Res., 86, 798 (2008), Nagata, T., et al.: J. Pharmacol. Sci., 106, 423 (2008), Ikeda, Y., et al.: J. Ocular Pharmacol. Ther., 24, 230 (2008),<br></p>

<p>Impurity Ifosfamide EP Impurity A<br>Applications 3-((2-Chloroethyl)amino)propyl Dihydrogen Phosphate is a metabolite of Ifosfamide (I265000), which is a cytostatic drug.<br>References Gilard, V., et al.: J. Med. Chem., 42, 2542 (1999);<br></p>

<p>Applications A metal complex of Deferasirox (D228650) as oxidation catalysts. Coordination compound.<br>References Rouan, M., et al.: Biomed. Sci. Applic., 755, 203 (2001)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muetzel, W., et al.: Am.J. Neuroradiol., 4, 350 (1983), Dawson, P., et al.: Acta Radiol. Diagn., 25, 253 (1984),<br></p>

<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>

<p>Applications Labelled xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>

<p>Impurity Sofosbuvir Metabolite GS331007<br>Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.<br>References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)<br></p>

<p>Applications 1,2,3,4-Tetrahydro Argatroban is a metabolite of Argatroban (A769000); a synthetic thrombin inhibitor and antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981); Kikumoto, R., et al.: Biochemistry, 23, 85 (1984)<br></p>

<p>Stability Light Sensistive, Temperature Sensitive<br>Applications Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.<br>References Aiuchi, T., et al.: J. Biochem., 124, 300 (1998), Fisher, J.E., et al.: Proc. Natl. Acad. Sci. U.S.A. 96, 133 (1999), Montero, M.T., et al.: J. Immunol., 173, 4936 (2004), Campia, I., et al.: Br. J. Pharmacol., 158, 1777 (2009),<br></p>

<p>Impurity Brimonidine EP Impurity G<br>Applications A possible metabolite of Brimonidine (B677520).<br></p>