CAS 1007358-76-0

Formula: C22H22N2O4

InChI: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m0/s1

InChI key: OUJTZYPIHDYQMC-IBGZPJMESA-N

SMILES: CC1=CC(=NC(=N1)O[C@@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

Ambrisentan R-Enantiomer

CAS: 1007358-76-0

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₂₂H₂₂N₂O₄

Color and Shape: White Fine Powder

Molecular weight: 378.15796

Ref: 45-1019188

(R)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

CAS: 1007358-76-0

(R)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

Formula: C₂₂H₂₂N₂O₄

Purity: 95%

Molecular weight: 378.42

Ref: 54-OR1125996

(R)-Ambrisentan

CAS: 1007358-76-0

Formula: C₂₂H₂₂N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 378.43

Ref: 4Z-A-315

(R)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

CAS: 1007358-76-0

Formula: C₂₂H₂₂N₂O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 378.4211

Ref: IN-DA01E62C

(R)-Ambrisentan

CAS: 1007358-76-0

Applications (R)-Ambrisentan is the R-isomer impurity of Ambrisentan (A575860), which is a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996); Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002); Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003);

Formula: C₂₂H₂₂N₂O₄

Color and Shape: Neat

Molecular weight: 378.42

Ref: TR-A575873

Avatrombopag Impurity 30

CAS: 1007358-76-0

Formula: C₁₆H₂₁Cl₂N₃O

Color and Shape: White To Off-White Solid

Molecular weight: 342.26

Ref: 4Z-A-315032

Avatrombopag Impurity 28

CAS: 1007358-76-0

Formula: C₁₄H₈Cl₂N₄S₄

Color and Shape: White To Off-White Solid

Molecular weight: 431.39

Ref: 4Z-A-315030

(R)-Ambrisentan

CAS: 1007358-76-0

(R)-Ambrisentan is an endothelin receptor antagonist, which is a pharmacological agent derived synthetically to target and inhibit specific cellular pathways. It is primarily utilized in the treatment of pulmonary arterial hypertension (PAH), where it plays a crucial role in modulating vascular function. The mode of action of (R)-Ambrisentan involves selective antagonism of the endothelin type A (ETA) receptors, which are responsible for vasoconstriction and proliferation of vascular smooth muscle cells. By blocking these receptors, it mitigates the effects of endothelin, a potent vasoconstrictor, thus reducing blood pressure and improving blood flow in pulmonary arteries.

Formula: C₂₂H₂₂N₂O₄

Purity: Min. 95%

Molecular weight: 378.40 g/mol

Ref: 3D-HQB35876

Ambrisentan (R)-Isomer

CAS: 1007358-76-0

Formula: C₂₂H₂₂N₂O₄

Molecular weight: 378.43

Ref: ST-EA-CP-A15015