CAS 1009104-85-1

1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one

Description:

1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one, with CAS number 1009104-85-1, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple aromatic and heterocyclic rings. This compound features a propenone moiety, indicating it has an α,β-unsaturated carbonyl group, which is often associated with reactivity in organic synthesis and potential biological activity. The presence of methoxy groups suggests that it may exhibit certain electronic properties, influencing its reactivity and solubility. Additionally, the isoquinoline and pyrrolopyridine components may contribute to its pharmacological profile, potentially making it of interest in medicinal chemistry. The compound's specific characteristics, such as melting point, solubility, and spectral properties, would typically be determined through experimental methods. Overall, this compound represents a class of molecules that may have applications in drug development or as research tools in various biochemical studies.

Formula: C₂₈H₂₇N₃O₃

InChI: InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3

InChI key: InChIKey=IJYPHMXWKKKHGT-UHFFFAOYSA-N

SMILES: C(=CC(=O)N1CC=2C(CC1)=CC(OC)=C(OC)C2)C3=C(N(C)C=4C3=CC=CN4)C5=CC=CC=C5

Synonyms:

• 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
• 1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one

2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-

CAS: 1009104-85-1

Formula: C₂₈H₂₇N₃O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 453.5323

Ref: IN-DA00035Q

1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one

CAS: 1009104-85-1

1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one

Purity: 97%

Molecular weight: 453.54g/mol

Ref: 54-OR1054411

SMAD3 Inhibtor, SIS 3

Controlled Product

CAS: 1009104-85-1

Formula: C₂₈H₂₇N₃O₃

Color and Shape: Neat

Molecular weight: 453.532

Ref: TR-S564500

Smad3 Inhibitor, SIS3

CAS: 1009104-85-1

SIS3 is a Smad3 inhibitor that inhibits the transcriptional activity of Runx2. It has been shown to inhibit the expression of osteogenic genes in a transcription-polymerase chain reaction (PCR) assay. This drug also suppresses the growth of tumor cells, such as choroidal neovascularization induced by growth factor-β1 (GF-β1) and collagen production in lung fibroblasts and hepatocyte-like cells. SIS3 has been shown to be effective against cancerous tumors, including breast cancer, lung cancer, and melanoma. This drug binds to the polymerase chain reaction (PCR) site on DNA and blocks transcription. The binding of SIS3 leads to an increase in phosphatase activity and a decrease in lb-100 activity, which inhibits cell proliferation.

Formula: C₂₈H₂₇N₃O₃

Purity: Min. 95%

Molecular weight: 453.53 g/mol

Ref: 3D-JQB10485

(Rac)-SIS3 free base

CAS: 1009104-85-1

SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

Formula: C₂₈H₂₇N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 453.53

Ref: TM-T12923