CAS 101477-54-7

Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

Description:

Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) is a chemical compound characterized by its piperazine core, which is a six-membered heterocyclic structure containing two nitrogen atoms. This compound features a bis(4-fluorophenyl)methyl group and a 2,3,4-trimethoxyphenylmethyl substituent, contributing to its complex structure and potential biological activity. The presence of fluorine atoms typically enhances the lipophilicity and metabolic stability of the compound. As a hydrochloride salt, it is likely to be more soluble in water compared to its free base form, which can facilitate its use in pharmaceutical applications. The trimethoxyphenyl group may impart additional pharmacological properties, making this compound of interest in medicinal chemistry. Its specific interactions and effects would depend on its molecular conformation and the presence of functional groups, which can influence its binding affinity to biological targets. Overall, this compound exemplifies the intricate design often found in drug development, aiming for enhanced efficacy and selectivity.

Formula: C₂₇H₃₀F₂N₂O₃·2ClH

InChI: InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H

InChI key: InChIKey=LOGVKVSFYBBUAJ-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=C(OC)C(OC)=C(OC)C=C2)CC1)(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4.Cl

Synonyms:

• 1-[Bis(4-Fluorophenyl)Methyl]-4-(2,3,4-Trimethoxybenzyl)Piperazine Dihydrochloride
• Kb 2796
• Lomerizine dihydrochloride
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
• Lomerizine hydrochloride

Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

CAS: 101477-54-7

Formula: C₂₇H₃₂Cl₂F₂N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 541.4574

Ref: IN-DA0004KV

Lomerizine-d8 DiHCl

CAS: 101477-54-7

Formula: C₂₇H₂₂D₈F₂N₂O₃·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 476.59 2*36.46

Ref: 4Z-L-242

Lomerizine dihydrochloride

CAS: 101477-54-7

Lomerizine dihydrochloride

Purity: ≥98%

Molecular weight: 541.46g/mol

Ref: 54-BUP15762

Lomerizine dihydrochloride

CAS: 101477-54-7

Formula: C₂₇H₃₀F₂N₂O₃·2HCl

Molecular weight: 541.46

Ref: 7W-GP1348

Lomerizine Dihydrochloride

CAS: 101477-54-7, 101477-55-8

Formula: C₂₇H₃₀F₂N₂O₃·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 541.46

Ref: 3B-L0245

Lomerizine dihydrochloride

CAS: 101477-54-7

Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.

Formula: C₂₇H₃₀F₂N₂O₃·2HCl

Purity: 99.26% - 99.80%

Color and Shape: Colourless Crystalline Solid

Molecular weight: 541.46

Ref: TM-T6571

Lomerizine Dihydrochloride

Controlled Product

CAS: 101477-54-7

Applications A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kanazawa, T., et al.: J. Cardiovasc. Pharmacol., 16, 430 (1990), Hara, H., et al.: Arch. Int. Pharmacodyn, 304, 206 (1990), Danielisova, V., et al.: Neurochem. Res., 19, 1503 (1994)

Formula: C₂₇H₃₀F₂N₂O₃·2ClH

Color and Shape: Neat

Molecular weight: 541.46

Ref: TR-L469430

Lomerizine dihydrochloride

CAS: 101477-54-7

Lomerizine dihydrochloride is a basic compound that is used as an anti-arrhythmic drug. It has been shown to be effective in the treatment of congestive heart failure, while also having the effect of inhibiting neuronal death. Lomerizine dihydrochloride has been shown to inhibit the activity of various enzymes, such as 5-HT2 receptors and mitochondrial ATPase, which are involved in energy metabolism. This drug also induces autophagy by increasing cytoplasmic calcium ion concentration and inhibiting protein synthesis.
Lomerizine dihydrochloride has been shown to have inhibitory properties against human serum proteins and is a substrate for phospholipase C, which leads to increased intracellular free Ca2+, preventing platelet aggregation.

Formula: C₂₇H₃₀F₂N₂O₃·2HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 541.46 g/mol

Ref: 3D-FL65066

Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

CAS: 101477-54-7

Purity: ≥98%

Molecular weight: 541.460022

Ref: 10-F865519