CAS 1037624-75-1: BGB 324

Description: BGB-324, with the CAS number 1037624-75-1, is a small molecule that functions primarily as a selective inhibitor of the enzyme Bruton’s tyrosine kinase (BTK). This compound has garnered attention in the field of medicinal chemistry and pharmacology, particularly for its potential therapeutic applications in treating various hematological malignancies and autoimmune diseases. BGB-324 exhibits a high degree of specificity for BTK, which plays a crucial role in B-cell receptor signaling and is implicated in the pathogenesis of certain cancers. The compound's mechanism of action involves the disruption of BTK-mediated signaling pathways, leading to the inhibition of cell proliferation and survival in malignant B cells. In terms of its physical and chemical properties, BGB-324 is characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. Ongoing research continues to explore its efficacy, safety profile, and potential combination therapies in clinical settings.

Formula: C₃₀H₃₄N₈

InChI: InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1

InChI key: InChIKey=KXMZDGSRSGHMMK-VWLOTQADSA-N

SMILES: N1=NC=2C3=CC=CC=C3CCCC2C=C1N4N=C(N=C4N)NC5=CC=C6C(=C5)CCC(N7CCCC7)CC6

Synonyms:

• BGB 324
• 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7-(S)-pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl]-1H-1,2,4-triazole-3,5-diamine
• 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine
• R 428
• 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

(S)-1-(6,7-Dihydro-5H-Benzo[6,7]Cyclohepta[1,2-C]Pyridazin-3-Yl)-N3-(7-(Pyrrolidin-1-Yl)-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-2-Yl)-1H-1,2,4-Triazole-3,5-Diamine

CAS: 1037624-75-1

• Purity: 98%
• Molecular weight: 506.64g/mol

Bemcentinib

CAS: 1037624-75-1

• Purity: 98.57%
• Molecular weight: 506.64g/mol

Bemcentinib

CAS: 1037624-75-1

Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated …

• Formula: C₃₀H₃₄N₈
• Purity: 97% - 99.8%
• Color and Shape: Solid
• Molecular weight: 506.64

R428

CAS: 1037624-75-1

R428

CAS: 1037624-75-1

Please enquire for more information about R428 including the price, delivery time and more detailed …

• Formula: C₃₀H₃₄N₈
• Purity: Min. 95%
• Molecular weight: 506.64 g/mol

R 428

CAS: 1037624-75-1

Applications R 428 is an AXL tyrosine kinase inhibitor shown to be used as an …

• Formula: C₃₀H₃₄N₈
• Color and Shape: Neat
• Molecular weight: 506.64