CAS 1037624-75-1

BGB 324

Description:

BGB-324, with the CAS number 1037624-75-1, is a small molecule that functions primarily as a selective inhibitor of the enzyme Bruton’s tyrosine kinase (BTK). This compound has garnered attention in the field of medicinal chemistry and pharmacology, particularly for its potential therapeutic applications in treating various hematological malignancies and autoimmune diseases. BGB-324 exhibits a high degree of specificity for BTK, which plays a crucial role in B-cell receptor signaling and is implicated in the pathogenesis of certain cancers. The compound's mechanism of action involves the disruption of BTK-mediated signaling pathways, leading to the inhibition of cell proliferation and survival in malignant B cells. In terms of its physical and chemical properties, BGB-324 is characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. Ongoing research continues to explore its efficacy, safety profile, and potential combination therapies in clinical settings.

Formula: C₃₀H₃₄N₈

InChI: InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1

InChI key: InChIKey=KXMZDGSRSGHMMK-VWLOTQADSA-N

SMILES: NC=1N(C=2C=C3C(C=4C(CCC3)=CC=CC4)=NN2)N=C(NC=5C=C6C(=CC5)CC[C@@H](CC6)N7CCCC7)N1

Synonyms:

• BGB 324
• 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7-(S)-pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl]-1H-1,2,4-triazole-3,5-diamine
• 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine
• R 428
• 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

(S)-1-(6,7-Dihydro-5H-Benzo[6,7]Cyclohepta[1,2-C]Pyridazin-3-Yl)-N3-(7-(Pyrrolidin-1-Yl)-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-2-Yl)-1H-1,2,4-Triazole-3,5-Diamine

CAS: 1037624-75-1

(S)-1-(6,7-Dihydro-5H-Benzo[6,7]Cyclohepta[1,2-C]Pyridazin-3-Yl)-N3-(7-(Pyrrolidin-1-Yl)-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-2-Yl)-1H-1,2,4-Triazole-3,5-Diamine

Purity: 99%

Molecular weight: 506.64g/mol

Ref: 54-OR1023128

Bemcentinib

CAS: 1037624-75-1

Bemcentinib

Purity: ≥95%

Molecular weight: 506.64g/mol

Ref: 54-BUP15305

Bemcentinib

CAS: 1037624-75-1

Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.

Formula: C₃₀H₃₄N₈

Purity: 97% - 99.8%

Color and Shape: Solid

Molecular weight: 506.64

Ref: TM-T6269

R428

CAS: 1037624-75-1

Ref: 7W-GW4897

R428

CAS: 1037624-75-1

R428 is a small-molecule drug that is capable of inhibiting the BCR-ABL kinase and blocking the progression of chronic myelogenous leukemia. It has been shown to be effective in both in vitro and in vivo studies, with reduced toxicity compared to other treatments. R428 has been shown to inhibit proliferation of breast cancer cells in vitro and reduce the size of solid tumours in mice. This drug also inhibits epithelial mesenchymal transition (EMT) from epithelial cells to mesenchymal cells, which may be a potential mechanism for its anticancer activity.

Formula: C₃₀H₃₄N₈

Purity: Min. 95%

Molecular weight: 506.64 g/mol

Ref: 3D-BR166805

R 428

Controlled Product

CAS: 1037624-75-1

Applications R 428 is an AXL tyrosine kinase inhibitor shown to be used as an anti-cancer agent.
References Torka, R. et al.: Neoplasia, 16, 301 (2014);

Formula: C₃₀H₃₄N₈

Color and Shape: Neat

Molecular weight: 506.64

Ref: TR-R060020