CAS 1038915-60-4

Niraparib

Description:

Niraparib is a small molecule inhibitor primarily used in the treatment of certain types of cancer, particularly ovarian cancer. It functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which interferes with the DNA repair mechanisms in cancer cells, leading to cell death. Niraparib is characterized by its ability to selectively target cancer cells with deficiencies in homologous recombination repair, such as those with BRCA mutations. The compound is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its chemical structure includes a pyridine ring and a nitrogen-containing heterocycle, contributing to its potency and selectivity. Niraparib has been shown to improve progression-free survival in patients with recurrent ovarian cancer, making it a significant therapeutic option in oncology. As with many cancer therapies, it may have side effects, including fatigue, nausea, and hematological toxicities, which require monitoring during treatment. Overall, Niraparib represents a targeted approach in cancer therapy, exemplifying the advancements in precision medicine.

Formula: C₁₉H₂₀N₄O

InChI: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

InChI key: InChIKey=PCHKPVIQAHNQLW-CQSZACIVSA-N

SMILES: C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1

Synonyms:

• (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
• 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide
• 2-[4-[(3S)-Piperidin-3-yl]phenyl]indazole-7-carboxamide
• 2H-Indazole-7-carboxamide 2-[4-(3S)-3-piperidinylphenyl]-
• Niraparib
• MK4827 (Niraparib)
• Niraparib (MK-4827)
• 2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indazole-7-carboxamide
• EOS-60867
• (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrocholoride
• 2-[4-(3S)piperidin-3-ylphenyl]-2H-indazol-7-carboxamide

2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide

CAS: 1038915-60-4

Formula: C₁₉H₂₀N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 320.3883

Ref: IN-DA0038ZU

Niraparib

CAS: 1038915-60-4

Formula: C₁₉H₂₀N₄O

Molecular weight: 320.40

Ref: 4Z-N-116001

Niraparib

CAS: 1038915-60-4

Niraparib

Purity: ≥98%

Molecular weight: 320.39g/mol

Ref: 54-BUP17146

Niraparib-d5

CAS: 1038915-60-4

Formula: C₁₉H₁₅D₅N₄O

Molecular weight: 325.43

Ref: 4Z-N-116003

Niraparib

CAS: 1038915-60-4

Color and Shape: Neat

Ref: 86-MM3944.00

Niraparib

CAS: 1038915-60-4

Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.

Formula: C₁₉H₂₀N₄O

Purity: 98% - 99.91%

Color and Shape: Solid

Molecular weight: 320.39

Ref: TM-T3231

Niraparib

Controlled Product

CAS: 1038915-60-4

Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)

Formula: C₁₉H₂₀N₄O

Color and Shape: Neat

Molecular weight: 320.39

Ref: TR-N481400

Niraparib-D5 Major, >90%

Controlled Product

CAS: 1038915-60-4

Formula: C₁₉D₅H₁₅N₄O

Purity: >90%

Color and Shape: Neat

Molecular weight: 325.419

Ref: TR-N481406

(S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

CAS: 1038915-60-4

Formula: C₁₉H₂₀N₄O

Purity: 95.0%

Molecular weight: 320.396

Ref: 10-F227536

MK 4827

CAS: 1038915-60-4

Inhibitor of PARP1 and PARP2 enzymes

Formula: C₁₉H₂₀N₄O

Purity: Min. 96 Area-%

Color and Shape: White Powder

Molecular weight: 320.39 g/mol

Ref: 3D-FP35532