CAS 107761-42-2

beta-Amyloid (1-42) human

Description:

Beta-Amyloid (1-42) is a peptide fragment derived from the amyloid precursor protein (APP) and is primarily associated with Alzheimer's disease. This peptide consists of 42 amino acids and is known for its propensity to aggregate, forming insoluble fibrils that contribute to the formation of amyloid plaques in the brains of affected individuals. The aggregation process is influenced by various factors, including pH, temperature, and the presence of metal ions. Beta-Amyloid (1-42) is characterized by its hydrophobic nature, which facilitates its self-assembly into oligomers and fibrils. These aggregates are believed to disrupt cellular function and promote neurotoxicity, leading to cognitive decline. The CAS number 107761-42-2 specifically identifies this peptide, which is often used in research to study the mechanisms of Alzheimer's disease and to develop potential therapeutic strategies. Its role in neurodegeneration makes it a significant focus in both basic and clinical research aimed at understanding and treating Alzheimer's disease.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Synonyms:

• Beta-Amyloid Peptide (1-42), Human
• Daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia
• Amyloid Beta-Peptide (1-42) (Human)
• Amyloid B-Protein Fragment 1-42
• Amyloidb-Peptide(1-42)(human)
• H-Asp-Ala-Glu-Phe-Arg-His-Asp--Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH
• H-asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Ile-Ala-OH
• Abeta 1-42
• β-Amyloid(1-42)Human
• Soy peptide
• Beta-Amyloid 1-42,human

Amyloid β (1-42), Human

CAS: 107761-42-2

For cellular and molecular biology applications

Color and Shape: Lyophilized powder, White

Ref: 02-J66387

Amyloid β-Protein (1-42) (HFIP-treated)

CAS: 107761-42-2

The peptide was obtained by dissolving Amyloid β-Protein (1-42) in HFIP, aliquoting, and removing the solvent as described in the literature. The morphology of the resulting peptide was studied by transmission electron microscopy (TEM). The magenta arrow points to the nucleation centers where aggregation starts. The yellow arrow indicates the fibrils which are formed as long thin helical structures with regular twists. See in the technical note.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 95.3%

Color and Shape: White

Molecular weight: 4514.1

Ref: 01-4090148

Amyloid β-Protein (1-42)

CAS: 107761-42-2

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer’s disease and late Down’s syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of this peptide corresponds to the sequence of human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer’s disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. For the preparation of Aβ for experimental use, Fezoui et al. (2000) found that solvation of synthetic peptide with sodium hydroxide (Aβ·NaOH) followed by lyophilization, produced stocks with superior solubility and fibrillogenesis characteristics. Solubilization of the pretreated material with neutral buffers resulted in a pH transition from ≈10.5 to neutral, avoiding the isoelectric point of Aβ (pI≈5.5), at which Aβ precipitation and aggregation propensity are maximal.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 92.1%

Color and Shape: White

Molecular weight: 4514.1

Ref: 01-4089802

Amyloid β-Protein (1-42)

CAS: 107761-42-2

Compared to the inner salt of Aβ42, the HCl salt of Aβ42 aggregates more readily at pH 7.4.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: > 80%

Color and Shape: Whitish

Molecular weight: 4514.1

Ref: 01-4045866

Amyloid β-Protein (1-42)

CAS: 107761-42-2

Bachem ID: 4061966.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 97.2%

Color and Shape: White Lyophilisate

Molecular weight: 4514.1

Ref: 01-4061966

Amyloid β-Protein (1-42)

CAS: 107761-42-2

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer’s disease and late Down’s syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of this peptide corresponds to the sequence of human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer’s disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 97.3%

Color and Shape: White Lyophilisate

Molecular weight: 4514.1

Ref: 01-4014447

ë?-Amyloid Peptide

CAS: 107761-42-2

ë?-Amyloid Peptide

Purity: 99%,from soybean peptide

Molecular weight: 4514.04g/mol

Ref: 54-BI12178

β-Amyloid (1-42), human

CAS: 107761-42-2

β-Amyloid (1-42), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 99.52%

Color and Shape: Solid

Molecular weight: 4514.04

Ref: TM-TP1007

Amyloid β Protein fragment 1-42 HCl Salt

CAS: 107761-42-2

Amyloid β Protein fragment 1-42 HCl Salt

Purity: 99%,from soybean peptide

Molecular weight: 0.00g/mol

Ref: 54-BIBA1018

Amyloid β Protein fragment 1-42

CAS: 107761-42-2

Amyloid β Protein fragment 1-42

Purity: (hplc): 90.9% (nh3) (Typical Value in Batch COA)

Color and Shape: white lyophilisate

Ref: 54-BIBA1000

β-Amyloid (1-42) Human

CAS: 107761-42-2

Amyloid β-peptide (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS.Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.Supplied as the TFA salt

Molecular weight: 4,514.04 g/mol

Ref: 3D-CRB1000088

Amyloid β-Protein (1-42) sodium salt

CAS: 107761-42-2

Amyloid β-Protein (1-42) is a fragment of the amyloid beta protein that is thought to be a major contributor to the development of Alzheimer's disease. Amyloid β-Protein (1-42) has been shown to have neuroprotective effects, as it reduces cell death in the brain and preserves memory. It binds to the β-catenin protein in neurons and protects against oxidative stress by reducing production of reactive oxygen species. This molecule also reduces microglia activation and tnf-α levels, which may reduce inflammation. Amyloid β-Protein (1-42) is found in plants such as pueraria lobata, and has been used for centuries in traditional Chinese medicine for its anti-inflammatory properties.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 4,514.04 g/mol

Ref: 3D-FA110103

Amyloid β-Protein (Human, 1-42)

CAS: 107761-42-2

Amyloid beta-protein (Aβ) is a peptide that is found in the human brain. It is one of the major components of amyloid plaque, which are deposits of a protein fragment in the brain that form as a result of aging and Alzheimer’s disease. It is produced by cleavage of the amyloid precursor protein (APP). Aβ has been shown to be toxic to cells, causing them to die. This toxicity may be due to its ability to inhibit ATP production and increase oxidative stress. Aβ can also induce apoptosis by binding to receptors on cell surfaces and activating intracellular signaling pathways. These events lead to activation of caspases, which are proteolytic enzymes that contribute to programmed cell death.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: Min. 95%

Molecular weight: 4,514 g/mol

Ref: 3D-PAM-4349

...Amyloid Beta-Protein (Human, 1-42)

CAS: 107761-42-2

Amino acids 1-42 of the Amyloid beta-protein (Aβ), a major plaque component in Alzheimer's Disease, a neurodegenerative disorder that affects memory and cognitive function. It is thought that these Aβ peptides can aggregate to form insoluble fibrils that are a hallmark of Alzheimer's disease and may contribute to neurodegeneration and cognitive decline.
Research is ongoing to better understand the mechanisms underlying Aβ-induced neurodegeneration and to develop therapies that target Aβ to prevent or treat Alzheimer's disease. Aβ peptides, particularly Aβ(1-42), are commonly used in research as a model for Alzheimer's disease to investigate the pathogenesis and potential therapeutic approaches.
This product is available in the trifluoroacetate salt form and as a 0.5mg vial.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: Min. 95%

Molecular weight: 4,514 g/mol

Ref: 3D-PAM-4349-V

Amyloid β-Protein (1-42) hydrochloride salt

CAS: 107761-42-2

Key subunit of extracellular plaques found in the brains of patients with Alzheimer's disease; Hydrochloride salt

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: Min. 95%

Molecular weight: 4,514.04 g/mol

Ref: 3D-FA109848

Amyloid β Protein Fragment 1-42

CAS: 107761-42-2

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Purity: 99%

Color and Shape: Solid

Molecular weight: 4514.038939999975

Ref: IN-DA00ILQE

Amyloid β-Protein (1-42) TFA salt

CAS: 107761-42-2

Key subunit of extracellular plaques found in the brains of patients with Alzheimer's disease. TFA salt; 95%.

Formula: C₂₀₃H₃₁₁N₅₅O₆₀S

Molecular weight: 4,514.1 g/mol

Ref: 3D-PP50066