CAS 1088965-37-0

GSK-923295

Description:

GSK-923295, with the CAS number 1088965-37-0, is a small molecule that has been investigated primarily for its potential therapeutic applications in the treatment of various diseases, particularly in the field of oncology. It functions as a selective inhibitor of certain protein kinases, which play crucial roles in cell signaling pathways that regulate cell growth, division, and survival. The compound's mechanism of action typically involves the modulation of specific pathways associated with cancer cell proliferation and survival, making it a candidate for targeted cancer therapies. In terms of its physical and chemical properties, GSK-923295 is characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity and solubility. As with many investigational compounds, detailed studies on its pharmacokinetics, toxicity, and efficacy are essential for understanding its potential as a therapeutic agent. Further research is necessary to fully elucidate its characteristics and applications in clinical settings.

GSK-923295

CAS: 1088965-37-0

GSK-923295

Formula: C₃₂H₃₈ClN₅O₄

Purity: ≥95%

Molecular weight: 592.13

Ref: 54-BUP02645

GSK-923295

CAS: 1088965-37-0

GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).

Formula: C₃₂H₃₈ClN₅O₄

Purity: 96.22% - 98.02%

Color and Shape: White Solid

Molecular weight: 592.13

Ref: TM-T2039

GSK-923295

CAS: 1088965-37-0

3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide

Formula: C₃₂H₃₈ClN₅O₄

Purity: 98%

Molecular weight: 592.13

Ref: IN-DG234814

GSK 923295

Controlled Product

CAS: 1088965-37-0

Applications GSK 923295 is the first potent, CENP-E-selective inhibitor that has been tested in Phase I clinical trials for treatment of Refractory Cancers.
References Wood, K., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 5839 (2010); Qian, X., et al.: ACS Med. Chem. Lett., 1, 30 (2010); Lock, R., et al. Pediatr. Blood Cancer, 58, 916 (2012); Mayes, P., et al.: Int. J. Cancer, 132, E149 (2013)

Formula: C₃₂H₃₈ClN₅O₄

Color and Shape: Neat

Molecular weight: 592.13

Ref: TR-G797750

GSK 923295

CAS: 1088965-37-0

Inhibitor of mitotic kinesin CENP-E

Formula: C₃₂H₃₈ClN₅O₄

Purity: Min. 95%

Molecular weight: 592.13 g/mol

Ref: 3D-FG45994