CAS 1103522-45-7

Aprocitentan

Description:

Aprocitentan is a chemical compound classified as an endothelin receptor antagonist, specifically targeting the endothelin-1 receptor. It is primarily investigated for its potential therapeutic applications in treating conditions such as resistant hypertension and heart failure. The compound works by blocking the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. Aprocitentan is characterized by its high selectivity for the endothelin receptors, which contributes to its efficacy and safety profile. The molecular structure of Aprocitentan includes specific functional groups that facilitate its interaction with the receptor sites. In clinical studies, it has shown promise in improving cardiovascular outcomes, although its long-term effects and safety are still under evaluation. As with many pharmacological agents, potential side effects may include hypotension, fluid retention, and electrolyte imbalances, necessitating careful monitoring during treatment. Overall, Aprocitentan represents a significant advancement in the management of hypertension and related cardiovascular disorders.

Formula: C16H14Br2N6O4S

InChI: InChI=1S/C16H14Br2N6O4S/c17-11-3-1-10(2-4-11)13-14(24-29(19,25)26)22-9-23-15(13)27-5-6-28-16-20-7-12(18)8-21-16/h1-4,7-9H,5-6H2,(H2,19,25,26)(H,22,23,24)

InChI key: DKULOVKANLVDEA-UHFFFAOYSA-N

SMILES: C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br

Synonyms:

• Act-132577

Despropyl Macitentan

CAS: 1103522-45-7

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₆H₁₄Br₂N₆O₄S

Color and Shape: Off-White Solid

Molecular weight: 543.9164

Ref: 45-1A05650

N-Despropyl Macitentan

CAS: 1103522-45-7

Formula: C₁₆H₁₄Br₂N₆O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 546.1932

Ref: IN-DA008TD9

Aprocitentan

CAS: 1103522-45-7

Aprocitentan

Formula: C₁₆H₁₄Br₂N₆O₄S

Purity: ≥95%

Molecular weight: 546.19

Ref: 54-BUP15302

N-Despropyl Macitentan (Aprocitentan)

CAS: 1103522-45-7

Formula: C₁₆H₁₄Br₂N₆O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 546.19

Ref: 4Z-M-128003

Aprocitentan

CAS: 1103522-45-7

Aprocitentan (ACT-132577) is ETA and ETB antagonist .

Formula: C₁₆H₁₄Br₂N₆O₄S

Purity: 97.35%

Color and Shape: White Solid

Molecular weight: 546.19

Ref: TM-T7817

Aprocitentan

CAS: 1103522-45-7

N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide

Formula: C₁₆H₁₄Br₂N₆O₄S

Purity: 99%

Molecular weight: 546.19

Ref: IN-DG629899

Despropyl Macitentan-[13C2, d4]

CAS: 1103522-45-7

Formula: C₁₆H₁₄Br₂N₆O₄S

Molecular weight: 546.2

Ref: BE-MCD-7627

Aprocitentan

CAS: 1103522-45-7

Formula: C₁₆H₁₄Br₂N₆O₄S

Molecular weight: 546.2

Ref: BE-RMCM004002

Aprocitentan

CAS: 1103522-45-7

Purity: 98%

Molecular weight: 546.19

Ref: 10-F987627

N-Despropyl-macitentan

Controlled Product

CAS: 1103522-45-7

Applications N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
References Atsmon, J., et al.: Clin. Pharmacokinet., 525, 685 (2013); Sidharta, P.N., et al.: Clin. Drug Invest. (2014)

Formula: C₁₆H₁₄Br₂N₆O₄S

Color and Shape: Neat

Molecular weight: 546.19

Ref: TR-D297305

Aprocitentan

CAS: 1103522-45-7

Apcitentan is a vasoactive drug that belongs to the group of endothelin receptor antagonists. It is used in the treatment of erectile dysfunction and pulmonary hypertension. Apcitentan inhibits the angiotensin system, which includes angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R). This inhibition increases the levels of endothelin and dopamine β-hydroxylase, thereby decreasing blood pressure. Apcitentan has been shown to increase glomerular filtration rate and reduce proteinuria in patients with chronic kidney disease. In vivo studies have shown that apcitentan is rapidly absorbed from the gastrointestinal tract, reaching peak concentrations within one hour. The pharmacodynamics of apcitentan are characterized by an inhibitory effect on pde5. Pharmacokinetic studies have found that apcitentan is metabolized by CYP

Formula: C₁₆H₁₄Br₂N₆O₄S

Purity: Min. 95%

Molecular weight: 546.19 g/mol

Ref: 3D-DUB52245

N-Despropyl Macitentan

CAS: 1103522-45-7

Formula: C₁₆H₁₄Br₂N₆O₄S

Molecular weight: 546.19

Ref: ST-EA-CP-M5016