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CAS 112398-08-0

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Danofloxacin

Description:
Danofloxacin is a synthetic fluoroquinolone antibiotic primarily used in veterinary medicine, particularly for treating bacterial infections in livestock and poultry. It exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and transcription. Danofloxacin is characterized by its high potency, good tissue penetration, and relatively long half-life, which allows for effective dosing regimens. The compound is typically administered via injection and is known for its low toxicity profile in animals. Its chemical structure includes a bicyclic core with a fluorine atom, which enhances its antimicrobial efficacy. As with other fluoroquinolones, the use of Danofloxacin is subject to regulations to prevent the development of antibiotic resistance and ensure food safety, particularly in food-producing animals. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining appropriate therapeutic applications and withdrawal times before animal products enter the food supply.
Formula:C19H20FN3O3
InChI:InChI=1S/C19H20FN3O3/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26)/t11-,12-/m0/s1
InChI key:InChIKey=QMLVECGLEOSESV-RYUDHWBXSA-N
SMILES:O=C1C=2C(N(C=C1C(O)=O)C3CC3)=CC(=C(F)C2)N4[C@]5(C[C@@](C4)(N(C)C5)[H])[H]
Synonyms:
  • 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-3-quinolinecarboxylic acid
  • 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • 2,5-Diazabicyclo[2.2.1]heptane, 3-quinolinecarboxylic acid deriv.
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo(2.2.1)hept-2-yl)-4-oxo-, (1S)-
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-
  • Advocin
  • Advocip
  • Dafloxacin
  • Danofloxacin [INN:BAN]
  • Danofloxacine
  • See more synonyms
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