CAS 1126745-90-1

SILDENAFIL-D3

Description:

Sildenafil-D3, with the CAS number 1126745-90-1, is a deuterated form of sildenafil, which is primarily known for its use in treating erectile dysfunction and pulmonary arterial hypertension. The deuteration involves the substitution of hydrogen atoms with deuterium, a stable isotope of hydrogen, which can influence the pharmacokinetics and metabolic stability of the compound. Sildenafil itself functions as a phosphodiesterase type 5 (PDE5) inhibitor, enhancing the effects of nitric oxide and increasing blood flow to specific areas of the body. The characteristics of Sildenafil-D3 may include altered solubility, stability, and bioavailability compared to its non-deuterated counterpart. This modification can be beneficial in research settings, particularly in pharmacokinetic studies, as it allows for the differentiation between the drug and its metabolites in biological systems. Overall, Sildenafil-D3 retains the core pharmacological properties of sildenafil while potentially offering advantages in specific scientific applications.

Formula: C₂₂H₂₇D₃N₆O₄S

InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)/i3D3

InChI key: BNRNXUUZRGQAQC-HPRDVNIFSA-N

SMILES: [2H]C([2H])([2H])N1CCN(CC1)S(=O)(=O)C2=CC(=C(C=C2)OCC)C3=NC4=C(C(=O)N3)N(N=C4CCC)C

Synonyms:

• 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine-d3
• SILDENAFIL-D3
• 5-[2-Ethoxy-5-[[4-(Methyl-d3)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one

Sildenafil-d3

CAS: 1126745-90-1

Sildenafil-d3

Formula: C₂₂H₂₇D₃N₆O₄S

Molecular weight: 477.59

Ref: 54-DE3155

Sildenafil-d3 (N-methyl-d3-piperazine)

CAS: 1126745-90-1, 139755-83-2

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 477.60

Ref: 3U-D6366

Sildenafil-d3

Controlled Product

CAS: 1126745-90-1

Stability Store in Freezer
Applications Labelled Sildenafil, an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996), Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998),

Formula: C₂₂D₃H₂₇N₆O₄S

Color and Shape: Neat

Molecular weight: 477.595

Ref: TR-S435002

Sildenafil-d3

CAS: 1126745-90-1

Formula: C₂₂H₂₇D₃N₆O₄S

Molecular weight: 477.60

Ref: 4Z-S-06197

Sildenafil-d3

CAS: 1126745-90-1

Formula: C₂₂H₂₇D₃N₆O₄S

Molecular weight: 477.60

Ref: ST-EA-CP-IL0316

Sildenafil-D3

Controlled Product

CAS: 1126745-90-1

Formula: C₂₂D₃H₂₇N₆O₄S

Color and Shape: Neat

Molecular weight: 477.60

Ref: TR-S688781