CAS 112887-68-0
:Raltitrexed
Description:
Raltitrexed, with the CAS number 112887-68-0, is a synthetic antifolate and an antineoplastic agent primarily used in the treatment of certain types of cancer, particularly colorectal cancer. It functions as a thymidylate synthase inhibitor, disrupting DNA synthesis by mimicking the natural substrate, thereby interfering with the proliferation of cancer cells. Raltitrexed is characterized by its structural similarity to folate, which allows it to effectively inhibit the enzyme responsible for converting deoxyuridine monophosphate to thymidine monophosphate, a critical step in DNA replication. The compound is typically administered intravenously and has a relatively long half-life, which can influence dosing schedules. Its efficacy is often evaluated in combination with other chemotherapeutic agents, and it may exhibit side effects common to chemotherapy, such as myelosuppression and gastrointestinal disturbances. Raltitrexed's pharmacokinetics and dynamics are influenced by factors such as patient metabolism and tumor characteristics, making personalized treatment approaches important for optimizing therapeutic outcomes.
Formula:C21H22N4O6S
InChI:InChI=1S/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1
InChI key:InChIKey=IVTVGDXNLFLDRM-HNNXBMFYSA-N
SMILES:O=C1C=2C(=CC=C(CN(C)C=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3)C2)NC(C)=N1
Synonyms:- L-Glutamic acid, N-[[5-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
- N-[[5-[[(3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid
- L-Glutamic acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
- D 1694
- ICI-D 1694
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 11 products.
(S)-2-(5-(Methyl((2-Methyl-4-Oxo-1,4-Dihydroquinazolin-6-Yl)Methyl)Amino)Thiophene-2-Carboxamido)Pentanedioic Acid
CAS:(S)-2-(5-(Methyl((2-Methyl-4-Oxo-1,4-Dihydroquinazolin-6-Yl)Methyl)Amino)Thiophene-2-Carboxamido)Pentanedioic AcidFormula:C21H22N4O6SPurity:98%Molecular weight:458.49(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid
CAS:Formula:C21H22N4O6SPurity:98%Color and Shape:SolidMolecular weight:458.4876Raltitrexed
CAS:Formula:C21H22N4O6SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:458.49Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Formula:C21H22N4O6SPurity:98.99% - 99.29%Color and Shape:Yellow Crystalline PowderMolecular weight:458.49Raltitrexed
CAS:Controlled ProductApplications Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jodrell, D.I., et al.: Cancer Chemother. Pharmacol., 28, 331 (1991), Jackman, A.L., et al.: Eur. J. Cancer, 31A, 1277 (1995)Formula:C21H22N4O6SColor and Shape:NeatMolecular weight:458.49Raltitrexed
CAS:Anti-folate inhibitor of thymidylate synthaseFormula:C21H22N4O6SPurity:Min. 95%Color and Shape:SolidMolecular weight:458.49 g/mol
![(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-meth…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0038YQ.jpg&w=3840&q=75)
