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CAS 113-98-4

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Benzylpenicillin potassium

Description:
Benzylpenicillin potassium, commonly known as penicillin G potassium, is a beta-lactam antibiotic that is effective against a variety of Gram-positive bacteria and some Gram-negative bacteria. It is characterized by its white to off-white crystalline powder form, which is soluble in water and has a slightly acidic pH. The compound is typically administered via injection due to its instability in acidic environments, such as the stomach. Benzylpenicillin works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death, making it particularly useful in treating infections like pneumonia, meningitis, and syphilis. Its pharmacokinetics involve rapid distribution in body tissues, with a relatively short half-life, necessitating frequent dosing. Adverse effects may include allergic reactions, gastrointestinal disturbances, and, in rare cases, neurotoxicity at high doses. Due to the emergence of antibiotic resistance, its use is often guided by susceptibility testing. Overall, benzylpenicillin potassium remains a critical agent in the antibiotic arsenal, particularly for treating serious bacterial infections.
Formula:C16H18N2O4S·K
InChI:InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/t11-,12+,14-;/m1./s1
InChI key:InChIKey=OXYXVSUHBSRMFJ-LQDWTQKMSA-N
SMILES:C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(CC3=CC=CC=C3)=O)C2=O)(SC1(C)C)[H].[K]
Synonyms:
  • 3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2α,5α,6.beta]).-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monopotassium salt
  • 4-Thia-1-azabicyclo
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, monopotassium salt
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, monopotassium salt
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2α,5α,6β)]-, monopotassium salt
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, [2S-(2alpha,5alpha,6beta)]-, monopotassium salt
  • Benzylpenicillin potassium salt
  • Benzylpenicillinic acid potassium salt
  • Cosmopen
  • See more synonyms
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