CAS 114798-26-4: Losartan
Description:Losartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension and to protect the kidneys in patients with type 2 diabetes. It is characterized by its ability to selectively block the action of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical formula of Losartan is C22H23ClN6O, and it features a biphenyl structure with a tetrazole ring, contributing to its pharmacological properties. Losartan is typically administered orally and exhibits a relatively long half-life, allowing for once-daily dosing. It is well-absorbed in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. The drug is metabolized primarily in the liver, with its active metabolite contributing to its antihypertensive effects. Common side effects may include dizziness, fatigue, and potential renal impairment, necessitating monitoring in patients with pre-existing kidney conditions. Overall, Losartan is a widely used medication in managing cardiovascular health and offers a favorable safety profile compared to some other antihypertensive agents.
Formula:C22H23ClN6O
InChI:InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChI key:InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N
SMILES:ClC=1N=C(N(C1CO)CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCCC
- Synonyms:
- 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
- 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
- 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
- DUP 89
- Losartan
![1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-](https://static.cymitquimica.com/products/IN/thumb/DA000F85.jpg)
