CAS 114949-13-2

Formula: C12H11ClO

InChI: InChI=1S/C12H11ClO/c13-12(14)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-2,4,6-7H,3,5,8H2

InChI key: IOESOTJLHGNTNA-UHFFFAOYSA-N

SMILES: C1CC2=CC=CC=C2C(=C1)CC(=O)Cl

3,4-Dihydro-1-naphthaleneacetyl Chloride

Controlled Product

CAS: 114949-13-2

Applications 3,4-Dihydro-1-naphthaleneacetyl Chloride is an intermediate used in the synthesis of 4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine (A603003), which is a highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase;Also, it is used in the synthesis of water-soluble chymotrypsin inhibitors.
References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005);Yokoo, N., et al.: Yakugaku Zasshi, 107, 732-737 (1987)

Formula: C₁₂H₁₁ClO

Color and Shape: Neat

Molecular weight: 206.67

Ref: TR-D452195