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CAS 119478-55-6

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Danofloxacin mesylate

Description:
Danofloxacin mesylate is a synthetic fluoroquinolone antibiotic primarily used in veterinary medicine for the treatment of bacterial infections in livestock and poultry. It exhibits broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria, by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and transcription. The mesylate salt form enhances its solubility and stability, facilitating its administration. Danofloxacin is characterized by its relatively low toxicity and favorable pharmacokinetic properties, including good tissue penetration and a prolonged half-life, which allows for less frequent dosing. It is typically administered via injection and is effective against respiratory and systemic infections. As with other fluoroquinolones, there are concerns regarding the development of antibiotic resistance, and its use is regulated to minimize such risks. Additionally, safety assessments are crucial to ensure that residues do not persist in food products derived from treated animals, aligning with food safety standards.
Formula:C20H24FN3O6S
InChI:InChI=1/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1
SMILES:CN1C[C@@H]2C[C@H]1CN2c1cc2c(cc1F)c(=O)c(cn2C1CC1)C(=O)O.CS(=O)(=O)O
Synonyms:
  • Danofloxacin Mesilate
  • Danofloxacin Mesulate
  • Danofloxancin Mesylate
  • 1-Cyclopropyl-6-Fluoro-7-[(1S,4S)-5-Methyl-2,5-Diazabicyclo[2.2.1]Hept-2-Yl]-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Monomethanesulfonate
  • Nofloxacin
  • Advoci
  • Cp-76136-27
  • 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1)
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