CAS 80-08-0
:Dapsone
Description:
Dapsone, with the CAS number 80-08-0, is an aromatic sulfonamide antibiotic primarily used in the treatment of leprosy and certain types of dermatitis, such as dermatitis herpetiformis. It is a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Dapsone functions by inhibiting bacterial folate synthesis, thereby exerting its antimicrobial effects. Its chemical formula is C12H12N2O2S, and it has a molecular weight of approximately 240.3 g/mol. Dapsone is known for its anti-inflammatory properties, making it effective in treating autoimmune skin conditions. While generally well-tolerated, it can cause side effects such as hemolytic anemia, especially in individuals with glucose-6-phosphate dehydrogenase deficiency. Monitoring of blood parameters is recommended during treatment. Dapsone is often used in combination with other medications to enhance therapeutic efficacy and reduce the risk of resistance.
Formula:C12H12N2O2S
InChI:InChI=1/C12H10O2S.C7H6N2O5/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12;1-4-2-5(8(11)12)3-6(7(4)10)9(13)14/h1-10H;2-3,10H,1H3
InChI key:InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=CC=C(N)C=C1)C2=CC=C(N)C=C2
Synonyms:- 1,1'-Sulfonylbis[4-aminobenzene]
- 1358F
- 4,4'-Dapsone
- 4,4'-Dds
- 4,4'-Diamino Diphenyl Sulfone
- 4,4'-Diamino Diphenyl Sulphone
- 4,4'-Diaminodiphenylsulfon
- 4,4'-Diaminodiphenylsulfone
- 4,4'-Sulfonylbisaniline
- 4,4'-Sulfonylbisbenzamine
- 4,4'-Sulfonyldiphenylamine
- 4,4-Diaminodiphenyl sulfone
- 4,4-Diaminodiphenyl sulphone
- 4,4-Sulfonyldianiline
- 4,4-Sulphonyldianiline
- 4,4′-Diaminobiphenyl sulfone
- 4,4′-Sulfonylbis[benzenamine]
- 4-((4-Aminophenyl)Sulfonyl)Phenylamine
- 4-(4-Aminophenyl)sulfonylaniline
- 4-(4-Aminophenylsulfonyl)benzenamine
- 4-Aminophenyl sulphone
- 44Dds
- Aczone
- Aniline, 4,4'-sulfonyldi-
- Aradur 9664-1
- Aradur 9664-1NL
- Aradur 976
- Aradur 976-1
- Aradur 9761-1
- Araldite HT 976
- Atrisone
- Avlosulfon
- Avlosulfone
- Avlosulphone
- Benzenamine, 4,4'-sulfonylbis-
- Bis(4-aminophenyl) sulfone
- Bis(P-Aminophenyl)Sulfone
- Croysulfone
- Croysulphone
- D 0089
- DDS
- DDS (pharmaceutical)
- DSS
- Dadfs
- Dadps
- Dapson
- Dapsone
- Di(4-Aminophenyl) Sulphone
- Di(4-aminophenyl)sulfone
- Di(p-aminophenyl) sulfone
- Diaminodiphenylsulfone
- Diaphenylsulfon
- Diaphenylsulfone
- Diphenasone
- Diphenyl Sulfone, 4,4'-Diamino-
- Diphone
- Disulone
- Dumitone
- Eporal
- F 1358
- Hardener HT 976
- Hb-Mc-Ge 40
- Hb-Mc-Ge 45
- Hew 62
- Ht 9664
- Ht 976
- Ht 976-1
- Hy 976
- Lapox K 10
- Metabolite C
- Novophone
- Nsc 6091
- P,P'-Sulfonyldianiline
- P-Aminophenyl Sulfone
- Seikacure S
- Servidapson
- Sulfona
- Sulfona-Mae
- Sulphadione
- Sumicure S
- Timtec-Bb Sbb003168
- Udolac
- p,p'-Diaminodiphenyl sulfone
- 4,4'-SULFONYLBISBENZENEAMINE
- Dapsonum
- 4,4-DIAMINODIPHENYLSULPHONE
- 4-AMINOPHENYL SULONE
- See more synonyms
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Bis(4-aminophenyl) Sulfone
CAS:Formula:C12H12N2O2SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:248.304,4'-Diaminodiphenyl sulfone, 98%
CAS:It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for theFormula:C12H12N2O2SPurity:98%Color and Shape:White to pale cream, PowderMolecular weight:248.30Dapsone
CAS:Other aromatic organo-sulfur compounds (excluding pesticides)Formula:C12H12N2O2SColor and Shape:White Off-White Light Yellow Crystalline PowderMolecular weight:248.061954,4'-Sulfonyldianiline
CAS:Formula:C12H12N2O2SPurity:98%Color and Shape:SolidMolecular weight:248.3009Dapsone
CAS:Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Formula:C12H12N2O2SPurity:99.84% - 99.86%Color and Shape:SolidMolecular weight:248.30Dapsone
CAS:Formula:C12H12N2O2SPurity:(Titration) 98.0 - 102.0 %Color and Shape:White to off-white crystalline powderMolecular weight:248.30Bis(4-aminophenyl) Sulfone
CAS:Bis(4-aminophenyl) SulfoneFormula:C12H12N2O2SPurity:>99%Color and Shape:SolidMolecular weight:248.30087Smart Solutions™ v59 PharmaVetResiMix Kit 1
CAS:Controlled Product- 100-90-3
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- 42835-25-6
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- 53716-50-0
- 54029-12-8
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- 59-40-5
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- 68-35-9
- 68786-66-3
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- 71751-41-2
- 72-14-0
- 723-46-6
- 729-99-7
- 74011-58-8
- 75184-71-3
- 79660-72-3
- 80-08-0
- 80-32-0
- 80-35-3
- 80983-34-2
- 82419-36-1
- 85721-33-1
- 88254-99-3
- 91296-86-5
- 91296-87-6
- 93106-60-6
- 948-71-0
- 98079-52-8
Color and Shape:MixtureDapson 100 µg/mL in Methanol
CAS:Controlled ProductFormula:C12H12N2O2SColor and Shape:ColourlessMolecular weight:248.30Dapsone
CAS:Controlled ProductApplications An antibacterial used in the treatment of dermatitis herpetiformis.
References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),Formula:C12H12N2O2SColor and Shape:NeatMolecular weight:248.3
