CAS: 1195765-45-7 - n-(3-(5-(2-amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Formula: C₂₃H₂₀F₃N₅O₂S₂

InChI: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)

InChI key: InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N

SMILES: O=S(=O)(NC=1C=CC=C(C1F)C=2N=C(SC2C=3N=C(N=CC3)N)C(C)(C)C)C=4C(F)=CC=CC4F

Synonyms:

• Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
• Dabarefenib
• Dabrafenib
• Debrafenib free base
• Gsk 2118436
• Gsk 436
• N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
• N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
• Tafinlar
• Tafmlar

Dabrafenib

CAS: 1195765-45-7

• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Color and Shape: Off-White Solid
• Molecular weight: 519.57

Dabrafenib

CAS: 1195765-45-7

• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Molecular weight: 519.56

Dabrafenib

CAS: 1195765-45-7

Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is …

• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Purity: 100%
• Color and Shape: Solid
• Molecular weight: 519.56

Dabrafenib

CAS: 1195765-45-7

Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a …

• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Color and Shape: White to Off-White Solid
• Molecular weight: 519.56

Dabrafenib

CAS: 1195765-45-7

Inhibitor of mutant B-rafV600E protein that results in decreased proliferation of cancer cells with this …

• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 519.56 g/mol