CAS 123318-82-1
:Clofarabine
Description:
Clofarabine is a synthetic nucleoside analog primarily used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It is characterized by its structure, which includes a purine base and a sugar moiety, modified to enhance its efficacy and stability. Clofarabine exhibits antineoplastic properties by interfering with DNA synthesis and repair, ultimately leading to apoptosis in cancer cells. Its mechanism of action involves inhibition of DNA polymerase and ribonucleotide reductase, which are crucial for DNA replication and repair processes. The compound is typically administered intravenously and is known for its potential side effects, including myelosuppression, gastrointestinal disturbances, and infections due to immunosuppression. Clofarabine's pharmacokinetics indicate a relatively short half-life, necessitating careful dosing and monitoring during treatment. Overall, it represents a significant advancement in targeted cancer therapies, particularly for patients with relapsed or refractory leukemia.
Formula:C10H11ClFN5O3
InChI:InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChI key:InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N
SMILES:NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)=NC(Cl)=N1
Synonyms:- 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
- 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
- (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
- 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
- Clolar
- 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
- 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- CAFDA
- 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
- Clofarabine
- 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- Clofarex
- (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
- See more synonyms
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Found 16 products.
Clofarabine
CAS:Formula:C10H11ClFN5O3Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:303.682-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%
CAS:<p>A purine nucleoside anti-metabolite. Toxic to nondividing lymphocytes and monocytes This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item c</p>Formula:C10H11ClFN5O3Purity:99+%Molecular weight:303.68Clofarabine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C10H11ClFN5O3Color and Shape:White Off-White PowderMolecular weight:303.05345Clofarabine System Suitability Mixture (This is a mixture containing clofarabine and clofarabine α anomer)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiColor and Shape:White Solid(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
CAS:Formula:C10H11ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:303.6774Ref: IN-DA000KCJ
1g212.00€5g525.00€10gTo inquire25gTo inquire5mg39.00€10mg38.00€50mg44.00€100mg58.00€250mg98.00€Clofarabine
CAS:<p>Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide</p>Formula:C10H11ClFN5O3Purity:99.94% - >99.99%Color and Shape:White SolidMolecular weight:303.68Clofarabine-13C-15N3
CAS:Formula:C913CH11ClFN215N3O3Color and Shape:White To Off-White SolidMolecular weight:307.65Clofarabine, free base
CAS:<p>Clofarabine, free base</p>Formula:C10H11ClFN5O3Purity:By hplc: 99.9% (Typical Value in Batch COA)Color and Shape: white powderMolecular weight:303.68g/molClofarabine
CAS:<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>Formula:C10H11ClFN5O3Color and Shape:White To Off-WhiteMolecular weight:303.68Clofarabine
CAS:<p>Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed</p>Formula:C10H11ClFN5O3Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:303.68 g/molClofarabine - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C10H11ClFN5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:303.68 g/mol
