CAS 123318-82-1: Clofarabine

Description:Clofarabine is a synthetic nucleoside analog primarily used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It is characterized by its structure, which includes a purine base and a sugar moiety, modified to enhance its efficacy and stability. Clofarabine exhibits antineoplastic properties by interfering with DNA synthesis and repair, ultimately leading to apoptosis in cancer cells. Its mechanism of action involves inhibition of DNA polymerase and ribonucleotide reductase, which are crucial for DNA replication and repair processes. The compound is typically administered intravenously and is known for its potential side effects, including myelosuppression, gastrointestinal disturbances, and infections due to immunosuppression. Clofarabine's pharmacokinetics indicate a relatively short half-life, necessitating careful dosing and monitoring during treatment. Overall, it represents a significant advancement in targeted cancer therapies, particularly for patients with relapsed or refractory leukemia.

Formula:C₁₀H₁₁ClFN₅O₃

InChI:InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChI key:InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N

SMILES:FC1C(O)C(OC1N2C=NC=3C(=NC(Cl)=NC32)N)CO

Synonyms:
2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
(2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
Clolar
2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
CAFDA
See more synonyms
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
Clofarabine
5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Clofarex
(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine

Found 15 products.

Product data	Purity	Price range	Estimated delivery
Clofarabine REF: 3B-C2500CAS: 123318-82-1	>98.0%(HPLC)	52.00 €~173.00 €	Tue 18 Mar 25
2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+% REF: 02-J60927CAS: 123318-82-1	99+%	To inquire	Mon 17 Mar 25
Clofarabine REF: 45-1138620CAS: 123318-82-1	- - -	1,554.00 €	Mon 24 Mar 25
Clofarabine System Suitability Mixture (This is a mixture containing clofarabine and clofarabine α anomer) REF: 45-1138621CAS: 123318-82-1	- - -	1,456.00 €	Mon 24 Mar 25
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)- REF: IN-DA000KCJCAS: 123318-82-1	97%	To inquire	Tue 25 Mar 25
Clofarabine REF: TM-T0297CAS: 123318-82-1	100% - 100%	43.00 €~360.00 €	Tue 25 Mar 25
Clofarabine REF: 4Z-C-11501CAS: 123318-82-1	- - -	To inquire	Mon 24 Mar 25
Clofarabine REF: 7W-GP5199CAS: 123318-82-1	- - -	To inquire	Mon 24 Mar 25
Clofarabine, free base REF: 54-BIFK0045CAS: 123318-82-1	By hplc: 99.9% (Typical Value in Batch COA)	288.00 €	Mon 24 Mar 25
Clofarabine-13C-15N3 REF: 4Z-C-11508CAS: 123318-82-1	- - -	To inquire	Mon 24 Mar 25
Clofarabine REF: 86-MM3521.00CAS: 123318-82-1	- - -	746.00 €	Wed 26 Mar 25
CLOFARABINE REF: 10-F387706CAS: 123318-82-1	99.0%	96.00 €~482.00 €	Wed 26 Mar 25
Clofarabine REF: TR-C586890CAS: 123318-82-1	- - -	99.00 €~696.00 €	Wed 02 Apr 25
Clofarabine - Bio-X ™ REF: 3D-BC300153CAS: 123318-82-1	Min. 95%	145.00 €	Thu 03 Apr 25
Clofarabine REF: 3D-NA07154CAS: 123318-82-1	Min. 98 Area-%	184.00 €~1,901.00 €	Thu 03 Apr 25