CAS 124168-73-6

P-aminobenzoyl-gly-pro-D-leu-D-ala*hydroxamic aci

Description:

P-aminobenzoyl-gly-pro-D-leu-D-ala*hydroxamic acid, with the CAS number 124168-73-6, is a synthetic compound that features a combination of amino acids and a hydroxamic acid functional group. This compound is characterized by its structural complexity, which includes an aromatic amine (P-aminobenzoyl), a peptide backbone (gly-pro-D-leu-D-ala), and a hydroxamic acid moiety. The presence of the hydroxamic acid group is significant as it can form chelates with metal ions and is often associated with biological activity, particularly in the context of enzyme inhibition. The peptide components suggest potential bioactivity, possibly related to interactions with biological receptors or enzymes. Additionally, the stereochemistry of the amino acids indicates that this compound may exhibit specific conformational properties that could influence its biological interactions. Overall, this compound may be of interest in medicinal chemistry and pharmacology, particularly in the development of therapeutic agents targeting specific biological pathways.

Formula: C₂₃H₃₄N₆O₆

InChI: InChI=1/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1

Synonyms:

• 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH
• p-Aminobenzyl-Gly-Pro-D-Leu-D-Ala Hydroxamic acid
• N-[(4-aminophenyl)carbonyl]glycyl-L-prolyl-D-leucyl-N-hydroxy-D-alaninamide
• MMP Inhibitor I

4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH

CAS: 124168-73-6

The water-soluble peptidylhydroxamic acid FN439 is a broad-spectrum inhibitor of human matrix metalloproteinases. 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH retains its activity even after prolonged incubation with pronase or human granulocyte elastase. FN 439 inhibits interstitial and granulocyte collagenases, granulocyte gelatinase and skin fibroblast stromelysin with IC₅₀ of 1 · 10⁻⁶ M, 3 · 10⁻⁵ M and 1.5 · 10⁻⁴ M, respectively.

Formula: C₂₃H₃₄N₆O₆

Purity: > 98%

Color and Shape: White Lyophilisate

Molecular weight: 490.56

Ref: 01-4025806

(2R)-2-((2R)-2-((S)-1-(2-(4-Aminobenzamido)acetyl)pyrrolidine-2-carboxamido)-5-(hydroxyamino)-4-methyl-5-oxopentanamido)propanoic acid

CAS: 124168-73-6

Formula: C₂₃H₃₄N₆O₆

Molecular weight: 490.5527

Ref: IN-DA000LMH

4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid

CAS: 124168-73-6

Formula: C₂₃H₃₄N₆O₆

Molecular weight: 490.55

Ref: 7W-GK5599

4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

CAS: 124168-73-6

4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt is a synthetic, hydroxamic acid that inhibits the activity of collagenase, gelatinase and stromelysin. It also has inhibitory activities against metalloproteinases, such as matrix metalloproteinases and serine proteinases. 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt has been shown to inhibit the production of proinflammatory cytokines in human skin fibroblasts. This agent also induces the production of granulocytes in vitro.

Formula: C₂₃H₃₄N₆O₆

Purity: Min. 95%

Molecular weight: 490.55 g/mol

Ref: 3D-FA111048