CAS 133073-73-1: L-amethopterin hydrate

Description: L-amethopterin hydrate, also known as methotrexate, is a potent antimetabolite and antifolate medication primarily used in the treatment of certain cancers and autoimmune diseases. It functions by inhibiting dihydrofolate reductase, an enzyme critical for DNA synthesis and cell replication, thereby impeding the growth of rapidly dividing cells. This compound is characterized by its crystalline structure and is typically soluble in water, which facilitates its administration in clinical settings. L-amethopterin hydrate exhibits a range of pharmacological effects, including immunosuppressive properties, making it valuable in treating conditions like rheumatoid arthritis and psoriasis. Its use, however, is accompanied by potential side effects, including toxicity to normal rapidly dividing cells, which necessitates careful monitoring during therapy. The compound's chemical stability and solubility profile are essential for its formulation in various dosage forms, including oral tablets and injectable solutions. Overall, L-amethopterin hydrate is a critical agent in oncology and rheumatology, with a well-established role in modern medical practice.

Formula: C₂₀H₂₄N₈O₆

InChI: InChI=1/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

Methotrexate Hydrate

CAS: 133073-73-159-05-2

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: Light yellow to Brown powder to crystal
• Molecular weight: 454.45 (as Anhydrous)

Methotrexate hydrate(1:x)

CAS: 133073-73-1

• Formula: C₂₀H₂₄N₈O₆
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 472.4545599999999

Methotrexate Hydrate

CAS: 133073-73-1

• Purity: 97%+
• Molecular weight: 454.44g/mol

Methotrexate hydrate

CAS: 133073-73-1

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: ≤ 0.5%
• Color and Shape: Yellow to dark yellow powder
• Molecular weight: 454.44 (anhydrous)

Methotrexate hydrate, USP grade

CAS: 133073-73-1

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: ≤ 3.0%
• Color and Shape: Yellow to dark yellow-orange powder
• Molecular weight: 454.44 (anhydrous)

L(+)-Amethopterin hydrate, 99%

CAS: 133073-73-1

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₀H₂₂N₈O₅
• Purity: 99%
• Color and Shape: Yellow to orange, Crystalline powder
• Molecular weight: 454.45

L(+)-Amethopterin hydrate

CAS: 133073-73-1

L(+)-Amethopterin hydrate is an immunosuppressant that suppresses the immune system by inhibiting RNA synthesis. It …

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: Min. 98 Area-%
• Color and Shape: Yellow Powder
• Molecular weight: 454.44 g/mol

Methotrexate Hydrate (MTR), 98%

CAS: 133073-73-1

• Formula: C₂₀H₂₂N₈O₅·xH₂O
• Purity: min. 98%
• Color and Shape: Yellow, Powder
• Molecular weight: 472.44 (anhy)