CAS 133073-73-1

L-amethopterin hydrate

Description:

L-amethopterin hydrate, also known as methotrexate, is a potent antimetabolite and antifolate medication primarily used in the treatment of certain cancers and autoimmune diseases. It functions by inhibiting dihydrofolate reductase, an enzyme critical for DNA synthesis and cell replication, thereby impeding the growth of rapidly dividing cells. This compound is characterized by its crystalline structure and is typically soluble in water, which facilitates its administration in clinical settings. L-amethopterin hydrate exhibits a range of pharmacological effects, including immunosuppressive properties, making it valuable in treating conditions like rheumatoid arthritis and psoriasis. Its use, however, is accompanied by potential side effects, including toxicity to normal rapidly dividing cells, which necessitates careful monitoring during therapy. The compound's chemical stability and solubility profile are essential for its formulation in various dosage forms, including oral tablets and injectable solutions. Overall, L-amethopterin hydrate is a critical agent in oncology and rheumatology, with a well-established role in modern medical practice.

Formula: C₂₀H₂₄N₈O₆

InChI: InChI=1/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

SMILES: CN(Cc1cnc2c(c(N)[nH]c(=N)n2)n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O

Methotrexate Hydrate

CAS: 133073-73-1, 59-05-2

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 454.45 (as Anhydrous)

Ref: 3B-M1664

Methotrexate xhydrate

CAS: 133073-73-1

Formula: C₂₀H₂₄N₈O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 472.4546

Ref: IN-DA00146X

Methotrexate hydrate

CAS: 133073-73-1

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purity: ≤ 0.5%

Color and Shape: Yellow to dark yellow powder

Molecular weight: 454.44 (anhydrous)

Ref: 7W-GA6211

Methotrexate Hydrate

CAS: 133073-73-1

Methotrexate Hydrate

Purity: 97%

Molecular weight: 454.44g/mol

Ref: 54-OR1013743

Methotrexate hydrate, USP grade

CAS: 133073-73-1

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purity: ≤ 3.0%

Color and Shape: Yellow to dark yellow-orange powder

Molecular weight: 454.44 (anhydrous)

Ref: 7W-GA8916

L(+)-Amethopterin hydrate

CAS: 133073-73-1

L(+)-Amethopterin hydrate is an immunosuppressant that suppresses the immune system by inhibiting RNA synthesis. It is a structural analogue of folic acid and has been shown to be effective in treating autoimmune diseases, such as rheumatoid arthritis. L(+)-Amethopterin hydrate is a neutral compound that is soluble in water and microsomal membranes, making it more easily absorbed through the gut than other compounds of this class. It also has been shown to have no toxic effects on cardiac cells at therapeutic concentrations. These properties make L(+)-Amethopterin hydrate an attractive candidate for treating autoimmune diseases when other treatments have failed.

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 454.44 g/mol

Ref: 3D-FA32143

Methotrexate Hydrate (MTR), 98%

CAS: 133073-73-1

Formula: C₂₀H₂₂N₈O₅·xH₂O

Purity: min. 98%

Color and Shape: Yellow, Powder

Molecular weight: 472.44 (anhy)

Ref: SR-86596