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CAS 13412-64-1

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Sodium dicloxacillin monohydrate

Description:
Sodium dicloxacillin monohydrate is a semisynthetic penicillin antibiotic, primarily used to treat infections caused by penicillinase-producing staphylococci. It is characterized by its ability to resist degradation by certain beta-lactamase enzymes, making it effective against a range of Gram-positive bacteria. The compound appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Its chemical structure includes a beta-lactam ring, which is essential for its antibacterial activity, and a side chain that enhances its stability against enzymatic hydrolysis. The monohydrate form indicates the presence of one molecule of water associated with each molecule of sodium dicloxacillin, which can influence its solubility and stability. In terms of pharmacokinetics, sodium dicloxacillin is typically administered via injection or orally, with its absorption and distribution influenced by the presence of food. As with all antibiotics, it is crucial to use sodium dicloxacillin judiciously to prevent the development of antibiotic resistance.
Formula:C19H17Cl2N3O5S·H2O·Na
InChI:InChI=1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/t13-,14+,17-;;/m1../s1
InChI key:InChIKey=QBFCIKYALGTFHK-VICXVTCVSA-N
SMILES:C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C(=NOC3C)C4=C(Cl)C=CC=C4Cl)C2=O)(SC1(C)C)[H].[Na].O
Synonyms:
  • 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin sodium salt monohydrate
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
  • Cloxacillin Sodium monohydrate
  • Dichlorstapenor sodium
  • Dicloxacillin sodium hydrate
  • Dicloxacillin sodium salt hydrate
  • P 1011
  • See more synonyms
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