CAS 134523-03-8

Atorvastatin Calcium

Description:

Atorvastatin Calcium is a pharmaceutical compound primarily used as a lipid-lowering agent to manage hyperlipidemia and reduce the risk of cardiovascular disease. It belongs to the class of drugs known as statins, which function by inhibiting the enzyme HMG-CoA reductase, a key player in cholesterol biosynthesis in the liver. This action leads to a decrease in low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol levels. Atorvastatin is typically administered orally and is well-absorbed in the gastrointestinal tract. Its solubility is influenced by pH, with better solubility in acidic conditions. The compound is characterized by its molecular formula, which reflects its complex structure, and it exists as a calcium salt to enhance its stability and bioavailability. Common side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances. As with all medications, atorvastatin should be used under medical supervision, considering potential interactions with other drugs and individual patient health profiles.

Formula: C₆₆H₆₈Ca₂F₂N₄O₁₀

InChI: InChI=1/2C33H35FN2O5.2Ca.2H/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;;;/q;;;+2;;/p-2/t2*26-,27-;;;;/m11..../s1/r2C33H35FN2O5.CaH2.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);1H2;/q;;;+2/p-2/t2*26-,27-;;/m11../s1

InChI key: InChIKey=BWFCZHDTTAYGNN-CNZCJKERSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca]

Synonyms:

• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5-Dihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt(L-4)
• (R-(R*,R*))-, Atorvastatin calcium
• 1H-Pyrrole-1-Heptanoicacid,Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methy Calciumsalt(2:1),(R-(R*,R*))-Lethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1), (R-(R*,R*))-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), [R-(R*,R*)]-
• 1H-Pyrrole-1-heptanoic acid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1)
• Atocor
• Atoraz
• Atorvastatin Ca
• Atorvastatin Calcium Anhydrous
• Atorvastatin Calsium
• Atorvastatin calcium (USAN)
• Atorvastatin calcium salt
• Atorvastatin hemicalcium
• Atorvastatin hemicalcium salt
• Atorvastatincalcuim
• Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Calcium Salt(2:1)
• C08078
• Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopr opyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate (1:2)
• Ci-981
• D00887
• Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Betcalci1H-Pyrrole-1-Heptanoicaci
• Drg-0321
• L-4
• Lipibec
• Lipitor
• Lipitor (TN)
• Lorvast
• Lowlip
• Ls-136974
• Pd 134298-38A
• Pd134298-38A
• Prevencor
• Rotacor
• Sortis
• Storvas
• Tahor
• Torvast
• Ym-548
• [R-(R*, R*)]-7-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-(Phenylaminocarbonyl)-1H-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid Calcium Salt
• calcium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-p ropan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate
• Atorvastatin calcium
• calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl)
• (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5-Dihydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 ydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy
• Atrovastatin calcium
• (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
• ATORVASTATINE CADIUM
• 3S,5S-Atorvastatin
• Atorvastatin Calclum
• ATORVASTATIN CALCIUM MM(CRM STANDARD)

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Formula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 1,209.41

Ref: 3B-A2476

Atorvastatin Calcium

CAS: 134523-03-8

Color and Shape: Neat

Ref: 61-FOR0400.00

Atorvastatin calcium

CAS: 134523-03-8

Atorvastatin calcium

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purity: 95.1%

Color and Shape: White

Molecular weight: 1154.45294

Ref: 47-1267

1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(βR,δR)-

CAS: 134523-03-8

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 1155.3417

Ref: IN-DA00368S

Atorvastatin Calcium Salt

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·5Ca

Color and Shape: White To Off-White Solid

Molecular weight: 557.65 0.5*40.08

Ref: 4Z-A-121

Atorvastatin calcium salt

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·5Ca·5H₂O

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: White to almost white crystalline powder

Molecular weight: 604.69

Ref: 7W-GP5009

Atorvastatin calcium

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·Ca

Color and Shape: Neat

Molecular weight: 1155.34

Ref: 04-C10318000

Atorvastatin Calcium

Controlled Product

CAS: 134523-03-8

Formula: C₃₃H₃₄FN₂O₅·Ca

Color and Shape: Neat

Molecular weight: 1155.34

Ref: 86-MM0400.00

Atorvastatin Impurity 61

CAS: 134523-03-8

Formula: C₄₀H₄₇FN₂O₆

Color and Shape: White To Off-White Solid

Molecular weight: 670.82

Ref: 4Z-A-12102

Atorvastatin hemicalcium salt

CAS: 134523-03-8

Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.

Formula: C₃₃H₃₄FN₂O₅Ca

Purity: 99.27% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 577.67

Ref: TM-T3116

Atorvastatin Calcium Salt

Controlled Product

CAS: 134523-03-8

Applications A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Zhao Y et al. Medicine (Baltimore). 2017 Feb;96(7):e6104.Wu X et al. Carcinogenesis. 2017 Feb 16Sepehri Z et al. PLoS One. 2017 Feb 13;12(2):e0172404

Formula: C₃₃H₃₄FN₂O₅·Ca

Color and Shape: White

Molecular weight: 1155.34

Ref: TR-A791750

Atorvastatin calcium

CAS: 134523-03-8

HMG-CoA reductase inhibitor; anti-hypercholesterolemia agent

Formula: C₆₆H₆₈CaF₂N₄O₁₀

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 1,155.34 g/mol

Ref: 3D-FA57652

Atorvastatin calcium salt - Bio-X ™

CAS: 134523-03-8

Atorvastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Formula: (C₃₃H₃₅FN₂O₅)₂•Ca

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,157.36 g/mol

Ref: 3D-BA164226