CAS 13739-02-1

diacerein

Description:

Diacerein is a chemical compound primarily recognized for its use as a pharmaceutical agent, particularly in the treatment of osteoarthritis. It is classified as an anthraquinone derivative and exhibits anti-inflammatory and analgesic properties. Diacerein functions as a selective inhibitor of interleukin-1, which plays a significant role in the inflammatory process associated with joint diseases. The compound is typically administered in its diacetylated form and is known for its relatively slow onset of action, often taking several weeks to achieve therapeutic effects. In terms of solubility, diacerein is moderately soluble in organic solvents but has limited solubility in water, which can affect its bioavailability. Its chemical structure includes a hydroxyl group and two acetyl groups, contributing to its pharmacological activity. While generally well-tolerated, diacerein may cause gastrointestinal side effects in some patients. Overall, its unique mechanism of action and therapeutic benefits make it a valuable option in managing chronic inflammatory conditions.

Formula: C₁₉H₁₂O₈

InChI: InChI=1/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)

InChI key: InChIKey=TYNLGDBUJLVSMA-UHFFFAOYSA-N

SMILES: O(C(C)=O)C1=C2C(C(=O)C=3C(C2=O)=C(OC(C)=O)C=CC3)=CC(C(O)=O)=C1

Synonyms:

• 1,8-Diacetoxy-3-carboxyanthraquinone
• 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-
• 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, diacetate
• 4,5-Bis(Acetyloxy)-9,10-Dioxo-9,10-Dihydroanthracene-2-Carboxylic Acid
• 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
• 4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid
• 4,5-Diacetoxy-9,10-dioxoanthracene-2-carboxylic acid
• 4,5-Diacetoxyanthraquinone-2-carboxylic acid
• 4,5-Diacetylrhein
• Ac 201
• Artrodar
• Diacerhein
• Diacetylrhein
• Fisiodar
• Inflabion
• Osteocerein
• Rhein, diacetate
• Sf 277
• 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate
• DIACEREIN
• 4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
• 1,8-diacetoxyanthraquinone-3-carboxylicacid
• Diacereine
• 9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
• DAR
• 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate
• DIACETYL RHEIN

Diacerein

CAS: 13739-02-1

Interleukin-1 inhibitor

Formula: C₁₉H₁₂O₈

Color and Shape: Yellow, Powder

Molecular weight: 368.30

Ref: 02-J63775

DIACEREIN CRS

CAS: 13739-02-1

DIACEREIN CRS

Formula: C₁₉H₁₂O₈

Color and Shape: Added Modified

Molecular weight: 368.2938

Ref: 41-Y0001595

Diacerein

CAS: 13739-02-1

Diacerein, metabolized to rhein, treats osteoarthritis in France but has side effects like severe diarrhea; also studied for type 2 diabetes.

Formula: C₁₉H₁₂O₈

Purity: 97.20% - 99.40%

Color and Shape: Solid

Molecular weight: 368.29

Ref: TM-T1273

Diacerein

CAS: 13739-02-1

Diacerein

Formula: C₁₉H₁₂O₈

Purity: >98%

Molecular weight: 368.3

Ref: 54-OR1029043

4,5-Diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 368.2938

Ref: IN-DA00138E

Diacerein

CAS: 13739-02-1

Diacerein

Formula: C₁₉H₁₂O₈

Purity: ≥95%

Molecular weight: 368.29

Ref: 54-BUP14552

Diacerein

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Molecular weight: 368.29

Ref: 7W-GP9028

Diacerein

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Molecular weight: 368.30

Ref: 4Z-D-307007

Diacerein

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 368.30

Ref: 3B-D4061

Diacerein

Controlled Product

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Color and Shape: Neat

Molecular weight: 368.29

Ref: 86-MM1318.00

Diacerein

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Purity: 95%~99%

Color and Shape: Yellow cryst.

Molecular weight: 368.297

Ref: BP-BP3435

Diacerein

CAS: 13739-02-1

4,5-Diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

Formula: C₁₉H₁₂O₈

Purity: 98%

Molecular weight: 368.29

Ref: IN-DG41269

Diacerein

CAS: 13739-02-1

Applications A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.
References Kay, A.G., et al.: Curr. Med. Res. Opin., 6, 548 (1980), Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982), Adami, S., et al.: Clin. Ter., 112, 439 (1985),

Formula: C₁₉H₁₂O₈

Color and Shape: Neat

Molecular weight: 368.29

Ref: TR-D303000

Diacerein

CAS: 13739-02-1

Inhibits interleukin-1B synthesis

Formula: C₁₉H₁₂O₈

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 368.29 g/mol

Ref: 3D-FD21422

Diacerein - Bio-X ™

CAS: 13739-02-1

Diacerein is a slow-onset anthraquinone IL-1 inhibitor that is used in the treatment of joint diseases such as osteoarthritis. This drug is also being studied for the treatment of insulin resistance and diabetes mellitus. Diacerein works to decrease inflammation and cartilage destruction by reducing the level of interleukin-1.

Formula: C₁₉H₁₂O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 368.29 g/mol

Ref: 3D-BD164367

4,5-Diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 368.297

Ref: 10-F516455

Diacerein

CAS: 13739-02-1

Formula: C₁₉H₁₂O₈

Molecular weight: 368.3

Ref: ST-EA-CP-D19000