CAS 1404-04-2

Neomycin

Description:

Neomycin is an aminoglycoside antibiotic primarily used to treat bacterial infections, particularly those caused by Gram-negative bacteria. It is derived from the bacterium Streptomyces fradiae and is known for its broad-spectrum antibacterial activity. Neomycin is characterized by its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, which disrupts the translation process. This antibiotic is often administered topically in ointments or eye drops due to its potential nephrotoxicity and ototoxicity when used systemically. Neomycin is also used in some formulations to prepare patients for surgery by reducing intestinal bacteria. Its solubility in water allows for easy formulation in various pharmaceutical preparations. However, its use is limited by the risk of adverse effects, including allergic reactions and toxicity, particularly in individuals with pre-existing kidney conditions. Overall, neomycin remains an important agent in the treatment of localized infections and as a part of combination therapies.

Formula: Unspecified

InChI: InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21?,22-,23?;/m1./s1

Synonyms:

• Bycomycin
• Fradiomycin
• Jernadex
• Myacyne
• Neomas
• Neomicina
• Neomin
• Neomycine
• Pimavecort
• Vonamycin Powder V
• (1R,2S,3R,6R)-3-amino-6-{[(1S,2R,3R,4R,5R)-2-amino-5-(aminomethyl)-3,4-dihydroxycyclohexyl]oxy}-2-hydroxycyclohexyl 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside
• (1R,2R,3S,4R,6S)-4,6-diamino-2-({3-O-[(5xi)-2,6-diamino-2,6-dideoxy-alpha-D-xylo-hexopyranosyl]-beta-D-ribofuranosyl}oxy)-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• CCRIS 5462
• Neolate
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (1:1)
• Neomycin
• Neomycinum
• EPA Pesticide Chemical Code 006303
• Neomycine [INN-French]
• HSDB 3242
• Nivemycin
• (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• Fradiomycinum
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-D-glucopyranoside sulfate (salt)
• Neomcin
• Caswell No. 595
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• Neomycinum [INN-Latin]
• Neomicina [DCIT]
• Mycifradin

Fradiomycin Sulfate

CAS: 1404-04-2, 1405-10-3

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄

Purity: >97.0%(N)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 908.87

Ref: 3B-F0649

Neomycin

CAS: 1404-04-2

Formula: C₂₃H₄₆N₆O₁₃

Molecular weight: 614.65

Ref: 4Z-N-080001

Neomycin (free base)

CAS: 1404-04-2

Neomycin, an antibiotic from Streptomyces fradiae, inhibits protein synthesis; comprises types A, B, C.

Formula: C₂₃H₄₆N₆O₁₃

Color and Shape: Solid

Molecular weight: 614.65

Ref: TM-T70752

Neomycin Trisulfate Hydrate Deuterated

Controlled Product

CAS: 1404-04-2

Applications Labelled analogue of Neomycin, an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Formula: C₂₃(DH)₄₆N₆O₁₃·3H₂SO₄·xH₂O

Color and Shape: Off White Solid

Molecular weight: 614.64+3(98.08)+x(18.01) (for undeuterated)

Ref: TR-N389977

Neomycin

CAS: 1404-04-2

Formula: C₂₃H₄₆N₆O₁₃

Color and Shape: Solid

Molecular weight: 614.6437

Ref: IN-DA001CCI