CAS 1404-04-2: Neomycin

Description: Neomycin is an aminoglycoside antibiotic primarily used to treat bacterial infections, particularly those caused by Gram-negative bacteria. It is derived from the bacterium Streptomyces fradiae and is known for its broad-spectrum antibacterial activity. Neomycin is characterized by its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, which disrupts the translation process. This antibiotic is often administered topically in ointments or eye drops due to its potential nephrotoxicity and ototoxicity when used systemically. Neomycin is also used in some formulations to prepare patients for surgery by reducing intestinal bacteria. Its solubility in water allows for easy formulation in various pharmaceutical preparations. However, its use is limited by the risk of adverse effects, including allergic reactions and toxicity, particularly in individuals with pre-existing kidney conditions. Overall, neomycin remains an important agent in the treatment of localized infections and as a part of combination therapies.

Formula: Unspecified

InChI: InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21?,22-,23?;/m1./s1

Synonyms:

• Bycomycin
• Fradiomycin
• Jernadex
• Myacyne
• Neomas
• Neomicina
• Neomin
• Neomycine
• Pimavecort
• Vonamycin Powder V
• (1R,2S,3R,6R)-3-amino-6-{[(1S,2R,3R,4R,5R)-2-amino-5-(aminomethyl)-3,4-dihydroxycyclohexyl]oxy}-2-hydroxycyclohexyl 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside
• (1R,2R,3S,4R,6S)-4,6-diamino-2-({3-O-[(5xi)-2,6-diamino-2,6-dideoxy-alpha-D-xylo-hexopyranosyl]-beta-D-ribofuranosyl}oxy)-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• CCRIS 5462
• Neolate
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (1:1)
• Neomycin
• Neomycinum
• EPA Pesticide Chemical Code 006303
• Neomycine [INN-French]
• HSDB 3242
• Nivemycin
• (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• Fradiomycinum
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-D-glucopyranoside sulfate (salt)
• Neomcin
• Caswell No. 595
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
• Neomycinum [INN-Latin]
• Neomicina [DCIT]
• Mycifradin
• UNII-I16QD7X297

Fradiomycin Sulfate

CAS: 1404-04-21405-10-3

• Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄
• Purity: >97.0%(N)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 908.87

Neomycin

CAS: 1404-04-2

• Formula: C₂₃H₄₆N₆O₁₃
• Molecular weight: 614.66

Neomycin (free base)

CAS: 1404-04-2

Neomycin, an antibiotic from Streptomyces fradiae, inhibits protein synthesis; comprises types A, B, C.

• Formula: C₂₃H₄₆N₆O₁₃
• Color and Shape: Liquid
• Molecular weight: 614.65

Neomycin Trisulfate Hydrate Deuterated

CAS: 1404-04-2

Applications Labelled analogue of Neomycin, an aminoglycoside antibiotic found in many topical medications. Neomycin has …

• Formula: C₂₃(DH)₄₆N₆O₁₃H₂SO₄·xH₂O
• Color and Shape: Off White Solid
• Molecular weight: 614.64+3(98.08)+x(18.01) (for undeuterated)

Neomycin

CAS: 1404-04-2

• Formula: C₂₃H₄₆N₆O₁₃
• Molecular weight: 614.6437 G/Mol

Neomycin

CAS: 1404-04-2

Neomycin is an antibiotic that inhibits the synthesis of proteins by binding to ribosomes and …

• Formula: C₂₃H₄₆N₆O₁₃
• Purity: Min. 95%
• Molecular weight: 614.6 g/mol