CAS 1405-20-5

polymyxin B

Description:

Polymyxin B is a cyclic polypeptide antibiotic primarily used to treat infections caused by Gram-negative bacteria. It is derived from the bacterium Bacillus polymyxa and exhibits a unique structure characterized by a hydrophobic tail and a positively charged peptide ring, which allows it to disrupt bacterial cell membranes. This disruption leads to increased permeability and ultimately cell lysis, making it effective against a range of pathogens, including Pseudomonas aeruginosa and Escherichia coli. Polymyxin B is often used in topical formulations due to its nephrotoxicity and neurotoxicity when administered systemically. It is commonly found in ointments, eye drops, and other topical preparations. Additionally, polymyxin B has gained attention in the context of antibiotic resistance, as it is sometimes used as a last-resort treatment for multidrug-resistant infections. Its use, however, is limited by potential side effects and the emergence of resistant bacterial strains, necessitating careful consideration in clinical applications.

Formula: C₅₆H₁₀₀N₁₆O₁₇S

InChI: InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

SMILES: CC(C)CC1C(=NC(CCN)C(=NC(CCN)C(=NC(CCO)C(=NCCC(C(=NC(CCN)C(=NC(Cc2ccccc2)C(=N1)O)O)O)N=C(C(CCN)N=C(C(CCO)N=C(C(CCN)N=CO)O)O)O)O)O)O)O.OS(=O)(=O)O

Synonyms:

• Aerosporin
• Mastimyxin
• N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid
• N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt)
• Polymixin B Sulfate
• Polymyxin B (PMB)
• Polymyxin B 2,5-SULFATE
• Polymyxin B Sulphate
• Polymyxin B sulfate salt
• Polymyxin B, Sulfat (Salz)
• Polymyxin B₁-polymyxin B₂ sulfate
• polimixina B, sulfato (sal)
• polymyxin B sulfate
• polymyxine B, sulfate (sel)
• Polimixin B Sulphate
• APPLISORB
• MYP SUPPLEMENT
• LISTERIA MONOCYTOGENES SELECTIVE SUPPLEMENT I
• POLYMYXIN B SULFATE, BACILLUS POLYMYXA
• POLYMIXIN B SULPHATE
• Polymyxin B solution
• LISTERIA MONO SELECTIVE SUPPLEMENT I
• POLYMYXIN B
• polymyxin B standard solution
• BACILLUS CEREUS SELECTIVE SUPPLEMENT
• BACILLUS CEREUS SELECTIVE AGAR BASE

Polymyxin B Sulfate

CAS: 1404-26-8, 1405-20-5

Color and Shape: White to Light yellow powder to crystal

Ref: 3B-P1923

Polymixin B sulfate, Cell Culture Reagent

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Formula: C₄₈H₈₄N₁₆O₁₇S

Color and Shape: White to pale yellow, Powder

Molecular weight: 1189.36

Ref: 02-J61763

Polymixin B sulfate

CAS: 1405-20-5

Polymixin B sulfate, 1405-20-5, is a polypeptide antibiotic which exhibits activity against gram-negative bacteria. Learn more at Thermo Fisher Scientific.

Formula: C₄₈H₈₄N₁₆O₁₇S

Color and Shape: Powder or crystalline powder, White to pale yellow

Molecular weight: 1189.36

Ref: 02-J63074

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE FOR MICROBIOLOGICAL ASSAY CRS

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Molecular weight: 1301.555

Ref: 41-Y0000355

Polymyxin B sulfate

CAS: 1405-20-5

Polymyxin B sulfate

Color and Shape: Colourless

Ref: 47-1028

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

CAS: 1405-20-5

SECOND INTERNATIONAL STANDARD FOR POLYMYXIN B

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Molecular weight: 1301.555

Ref: 41-ISA_67_301

POLYMYXIN B SULFATE CRS

CAS: 1405-20-5

POLYMYXIN B SULFATE CRS

Ref: 41-P2400000

Polymyxin B Sulfate

CAS: 1405-20-5

Antibiotics nesoi

Formula: C₅₆H₉₈N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₅H₉₆N₁₆O₁₃C₅₆H₉₈N₁₆O₁₃

Color and Shape: White Off-White Powder

Molecular weight: 4782.96841

Ref: 45-1547007

Polymyxin B, sulfate (salt)

CAS: 1405-20-5

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Color and Shape: Solid

Molecular weight: 1301.5552

Ref: IN-DA001CJX

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate, a mix of B1 and B2 from Bacillus polymyxa, fights gram-negative infections but may harm nerves and kidneys.

Formula: C₅₆H₁₀₀N₁₆O₁₇S

Purity: 8010u/mg - 98%

Color and Shape: White Crystalline Powder

Molecular weight: 1301.56

Ref: TM-T1100

Polymixin B sulphate

CAS: 1405-20-5

Polymixin B sulphate

Formula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Color and Shape: white to almost white powder

Molecular weight: 1,301.56g/mol

Ref: 54-BIP0145

Polymixin B sulfate salt

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Purity: ≥ 6000IU/mg (dried basis)

Color and Shape: White to pale yellow powder

Molecular weight: 1385.63

Ref: 7W-GA4910

Polymyxin B Sulfate

CAS: 1405-20-5

Polymyxin B Sulfate

Purity: ≥98%

Molecular weight: 1301.56g/mol

Ref: 54-BUP19624

Polymyxin B sulfate

Controlled Product

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃· 2H₂SO₄

Color and Shape: White To Off-White

Molecular weight: 1385.61

Ref: 04-C16283000

Polymyxin B Sulfate

CAS: 1405-20-5

Formula: C₅₆H₉₈N₁₆O₁₃·H₂O₄S

Molecular weight: 1203.50 98.07

Ref: 4Z-PP-321010

Polymyxin B1 Formate Salt

Controlled Product

CAS: 1405-20-5

Formula: C₅₆H₉₈N₁₆O₁₃·xHCOOH

Color and Shape: Off-White

Molecular weight: 1203.48 + x46.03

Ref: TR-P689406

Polymyxin B Sulfate

CAS: 1405-20-5

Applications Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixture of Polymyxin B1 and B2 sulfate.
References Coppi, G., et al.: J. Pharm. Pharmacol., 60, 21 (2008), Roche, S., et al.: Food Microbiol., 26, 21 (2008), Kawanishi, T., et al.: Plant Pathol., 58, 237 (2009),

Formula: C₅₅H₉₆N₁₆O₁₃H₂SO₄

Color and Shape: Neat

Molecular weight: 1385.61

Ref: TR-P689400

Polymyxin B sulfate

CAS: 1405-20-5

Membrane-disrupting agent

Formula: C₅₆H₉₈N₁₆O₁₃·H₂SO₄

Purity: Min 6000 Iu/Mg

Color and Shape: White Powder

Molecular weight: 1,301.56 g/mol

Ref: 3D-AP44829

Polymyxin B sulfate, Antibiotic for Culture Media Use Only

CAS: 1405-20-5

Polymyxin B is a sulfonamide antibiotic with broad spectrum of activity against Gram-negative bacteria. It binds to the bacterial membrane, causing an increase in the cell’s permeability and thus leading to cell death. A study on human neutrophils showed that polymyxin B reduces the expression of neomycin sulfate through inhibition of protein synthesis, which leads to cell death by lysosomal enzyme release. This antibiotic has been shown to be effective on clostridium perfringens, where it inhibits bacterial growth and leads to hypersensitivity reactions in some patients.

Formula: C₅₅H₁₀₀N₁₆O₂₁S₂

Purity: Min. 90.0 Area-%

Molecular weight: 1,385.61 g/mol

Ref: 3D-P-7010

Polymyxin B Sulphate (Aerosporin, PXNS), 6000U/mg for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 1405-20-5

Formula: C₅₅H₉₆N₁₆O₁₃·2H₂SO₄

Purity: min. 6000 units/mg

Color and Shape: White to pale yellow, Powder

Molecular weight: 1385.61

Ref: SR-52819