CAS 1435934-00-1

LDN 193189 hydrochloride

Description:

LDN 193189 hydrochloride is a small molecule inhibitor primarily known for its role in research related to the inhibition of bone morphogenetic protein (BMP) signaling pathways. It is characterized by its ability to selectively inhibit the activity of certain kinases involved in these pathways, making it a valuable tool in studies of cellular differentiation, development, and various disease processes. The compound is typically presented as a hydrochloride salt, which enhances its solubility in aqueous solutions, facilitating its use in biological assays. LDN 193189 hydrochloride is often utilized in in vitro and in vivo studies to explore its effects on stem cell differentiation and tissue regeneration. Its chemical structure includes specific functional groups that contribute to its inhibitory activity, and it is generally handled with standard laboratory safety precautions due to its biological activity. As with many research chemicals, its use is primarily confined to laboratory settings, and it is not approved for clinical use in humans.

Formula: C₂₅H₂₄Cl₂N₆

Synonyms:

• Viomycin LDN 193189 Dihydrochloride
• LDN-193189 2HCl
• LDN 193189 dihydrochloride
• 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride

LDN-193189 2HCl

CAS: 1435934-00-1

LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.

Formula: C₂₅H₂₄Cl₂N₆

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 479.4

Ref: TM-T35348

LDN-193189 (hydrochloride)

CAS: 1435934-00-1

Formula: C₂₅H₂₄Cl₂N₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 479.4043

Ref: IN-DA00ATET

LDN-193189 2HCl

CAS: 1435934-00-1

LDN-193189 2HCl

Formula: C₂₅H₂₄Cl₂N₆

Purity: ≥98%

Molecular weight: 479.4

Ref: 54-BUP13516

LDN 193189 dihydrochloride

CAS: 1435934-00-1

Inhibitor of ALK1, ALK2, ALK3 and ALK6 kinases and bone morphogenetic protein (BMP) pathway. LDN 1931189 is a dorsomorphin derivative that inhibits BMP-mediated activation of Smad, Akt and p38 signalling. LDN 193189 promotes differentiation of human pluripotent cells into PAX6+ anterior neural ectoderm. In combination with basic fibroblast growth factor (FGF2), LDN 193189 promotes differentiation of mouse pluripotent stem cells into inner ear sensory epithelium.

Formula: C₂₅H₂₂N₆·2HCl

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 479.4 g/mol

Ref: 3D-BL162781