CAS 143664-11-3: Elacridar
Description:Elacridar, with the CAS number 143664-11-3, is a chemical compound primarily recognized for its role as a potent inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). It is classified as a small molecule and is often studied in the context of pharmacology and drug development, particularly for its potential to enhance the bioavailability of various therapeutic agents by preventing their efflux from cells. Elacridar is characterized by its ability to cross the blood-brain barrier, making it of interest in the treatment of central nervous system disorders. The compound exhibits a relatively high affinity for the target proteins, which can lead to increased intracellular concentrations of co-administered drugs. Its chemical structure includes multiple aromatic rings and nitrogen-containing functional groups, contributing to its lipophilicity and interaction with biological membranes. Elacridar is primarily utilized in research settings to investigate drug-drug interactions and to improve the efficacy of anticancer therapies by overcoming multidrug resistance.
Formula:C34H33N3O5
InChI:InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
InChI key:InChIKey=OSFCMRGOZNQUSW-UHFFFAOYSA-N
SMILES:O=C(NC1=CC=C(C=C1)CCN2CC3=CC(OC)=C(OC)C=C3CC2)C4=CC=CC=5C(=O)C=6C=CC=C(OC)C6NC45
- Synonyms:
- 4-acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-
- Gf 120918
- Gf 129018
- Gg 918
- Gw 0918
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- N-{4-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- Elacridar
