P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
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Risperidone
CAS:106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 …
Formula:
C23H27FN4O2
Purity:
100%
Color and Shape:
Crystalline Solid
Molecular weight:
410.48
Ref: TM-T0351
| 10mg | 55.00 € | ||
| 25mg | 63.00 € | ||
| 50mg | 96.00 € | ||
| 100mg | 130.00 € | ||
| 200mg | 203.00 € | ||
| 500mg | 338.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Encequidar mesylate
CAS:849675-87-2
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Formula:
C39H40N6O10S
Purity:
99.67%
Color and Shape:
Solid
Molecular weight:
784.83
Ref: TM-T11578L
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 86.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 241.00 € | ||
| 100mg | 378.00 € | ||
| 500mg | 859.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Norverapamil hydrochloride
CAS:67812-42-4
Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.
Formula:
C26H37ClN2O4
Purity:
99.47%
Color and Shape:
Solid
Molecular weight:
477.04
Ref: TM-T16339
| 2mg | 34.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 273.00 € | ||
| 100mg | 381.00 € | ||
| 200mg | 539.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
(20S)-Protopanaxadiol
CAS:30636-90-9
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type
Formula:
C30H52O3
Purity:
98.03% - 98.91%
Color and Shape:
Solid
Molecular weight:
460.73
Ref: TM-T2799
| 5mg | 49.00 € | ||
| 10mg | 69.00 € | ||
| 50mg | 226.00 € | ||
| 100mg | 342.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Atazanavir sulfate
CAS:229975-97-7
Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.
Formula:
C38H52N6O7·H2SO4
Purity:
99.31% - 99.67%
Color and Shape:
Solid
Molecular weight:
802.93
Ref: TM-T0100
| 5mg | 46.00 € | ||
| 10mg | 61.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 119.00 € | ||
| 100mg | 176.00 € | ||
| 200mg | 259.00 € | ||
| 500mg | 440.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Trifluoperazine dihydrochloride
CAS:440-17-5
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and …
Formula:
C21H26Cl2F3N3S
Purity:
100% - 99.96%
Color and Shape:
Cream Fine Powder
Molecular weight:
480.43
Ref: TM-T1222
| 100mg | 54.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Dofequidar fumarate
CAS:153653-30-6
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance …
Formula:
C34H35N3O7
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
597.66
Ref: TM-T11071
| 1mg | 39.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 240.00 € | ||
| 50mg | 462.00 € | ||
| 100mg | 676.00 € | ||
| 500mg | 1,412.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Glibenclamide
CAS:10238-21-8
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Formula:
C23H28ClN3O5S
Purity:
99.1% - 99.77%
Color and Shape:
Solid
Molecular weight:
494
Ref: TM-T1634
| 1g | 62.00 € | ||
| 500mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Zamicastat
CAS:1080028-80-3
Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).
Formula:
C21H21F2N3OS
Purity:
99.58%
Color and Shape:
Solid
Molecular weight:
401.47
Ref: TM-T13383
| 1mg | 56.00 € | ||
| 5mg | 123.00 € | ||
| 10mg | 179.00 € | ||
| 25mg | 322.00 € | ||
| 50mg | 485.00 € | ||
| 100mg | 703.00 € | ||
| 200mg | 903.00 € | ||
| 1mL*10mM (DMSO) | 133.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Verapamil hydrochloride
CAS:152-11-4
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia …
Formula:
C27H39ClN2O4
Purity:
98.7% - 99.98%
Color and Shape:
White To Off-White Powder
Molecular weight:
491.06
Ref: TM-T1010
| 1g | 57.00 € | ||
| 500mg | 53.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Atazanavir
CAS:198904-31-3
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
Formula:
C38H52N6O7
Purity:
98% - 99.95%
Color and Shape:
Crystalline Solid
Molecular weight:
704.86
Ref: TM-T0100L
| 5mg | 46.00 € | ||
| 10mg | 68.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 122.00 € | ||
| 100mg | 201.00 € | ||
| 200mg | 300.00 € | ||
| 500mg | 508.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Piperine
CAS:94-62-2
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple …
Formula:
C17H19NO3
Purity:
100% - 97.79%
Color and Shape:
Solid
Molecular weight:
285.34
Ref: TM-T3002
| 100mg | 23.00 € | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Tuesday 5 Nov 2024
Valspodar
CAS:121584-18-7
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a …
Formula:
C63H111N11O12
Purity:
100% - 95%
Color and Shape:
Solid
Molecular weight:
1214.62
Ref: TM-T17216
| 1mg | 269.00 € | ||
| 5mg | 861.00 € | ||
| 10mg | 1,384.00 € | ||
| 25mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Larotaxel
CAS:156294-36-9
Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in …
Formula:
C45H53NO14
Purity:
99.22%
Color and Shape:
Solid
Molecular weight:
831.9
Ref: TM-T15713
| 1mg | 119.00 € | ||
| 5mg | 277.00 € | ||
| 10mg | 422.00 € | ||
| 25mg | 682.00 € | ||
| 50mg | 918.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
P-gb-IN-1
CAS:2632874-49-6
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.
Formula:
C30H28N2O6
Purity:
99.58%
Color and Shape:
Soild
Molecular weight:
512.55
Ref: TM-T77575
| 1mg | 182.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 643.00 € | ||
| 25mg | 1,003.00 € | ||
| 50mg | 1,384.00 € | ||
| 100mg | 1,841.00 € | ||
| 500mg | 3,647.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
YS-370
CAS:2470908-79-1
YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.
Formula:
C37H35BrN4O3
Purity:
97.50%
Color and Shape:
Solid
Molecular weight:
663.6
Ref: TM-T60009
| 1mg | 63.00 € | ||
| 2mg | 95.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 222.00 € | ||
| 25mg | 370.00 € | ||
| 50mg | 528.00 € | ||
| 100mg | 715.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to …
Formula:
C39H37F3N4O5
Purity:
98.74%
Color and Shape:
Soild
Molecular weight:
698.73
Ref: TM-T64133L
| 5mg | 6,293.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Evodine
CAS:6989-38-4
1. Evodine has antinociceptive activity.
Formula:
C18H19NO5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
329.35
Ref: TM-TCS2336
| 1mg | 55.00 € | ||
| 1mL*10mM (DMSO) | 121.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
FM04
CAS:1807320-40-6
FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to …
Formula:
C26H25NO4
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
415.48
Ref: TM-T72055
| 1mg | 183.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 647.00 € | ||
| 25mg | 1,007.00 € | ||
| 50mg | 1,383.00 € | ||
| 100mg | 1,830.00 € | ||
| 500mg | 3,648.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Selamectin
CAS:220119-17-5
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and …
Formula:
C43H63NO11
Purity:
99.64%
Color and Shape:
Solid
Molecular weight:
769.96
Ref: TM-T4059
| 5mg | 36.00 € | ||
| 10mg | 54.00 € | ||
| 25mg | 103.00 € | ||
| 50mg | 171.00 € | ||
| 100mg | 266.00 € | ||
| 200mg | 367.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
