CAS: 1448347-49-6 - Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-<span class="text-smallcaps">L</span>-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N²-(5-fluoro-3-pyridinyl)-, (2S)-

Formula: C₂₈H₂₂ClF₃N₆O₃

InChI: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

InChI key: InChIKey=WIJZXSAJMHAVGX-DHLKQENFSA-N

SMILES: N#CC=1C=CN=C(C1)N2C(=O)CCC2C(=O)N(C=3C=NC=C(F)C3)C(C(=O)NC4CC(F)(F)C4)C=5C=CC=CC5Cl

RG120

CAS: 1448347-49-6

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Color and Shape: Solid
• Molecular weight: 582.9609

Ivosidenib

CAS: 1448347-49-6

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: 100%
• Color and Shape: Solid
• Molecular weight: 582.96

Ivosidenib

CAS: 1448347-49-6

Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Color and Shape: White to Off-White Solid
• Molecular weight: 582.96

AG 120

CAS: 1448347-49-6

Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 582.96 g/mol