CAS 1448347-49-6: Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

Description: Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-, with CAS number 1448347-49-6, is a complex organic compound characterized by its multi-functional structure. It features a glycinamide backbone, which is a derivative of glycine, and incorporates various substituents that enhance its biological activity. The presence of a cyano group and multiple aromatic rings, including pyridine and chlorophenyl moieties, suggests potential interactions with biological targets, making it of interest in medicinal chemistry. The difluorocyclobutyl group may contribute to its lipophilicity and overall pharmacokinetic properties. Additionally, the compound's stereochemistry, indicated by the (2S) designation, is crucial for its biological activity, as stereoisomers can exhibit significantly different effects in biological systems. Overall, this compound's unique structural features may position it as a candidate for further research in drug development, particularly in areas targeting specific receptors or enzymes.

Formula: C₂₈H₂₂ClF₃N₆O₃

InChI: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

InChI key: InChIKey=WIJZXSAJMHAVGX-DHLKQENFSA-N

SMILES: N#CC=1C=CN=C(C1)N2C(=O)CCC2C(=O)N(C=3C=NC=C(F)C3)C(C(=O)NC4CC(F)(F)C4)C=5C=CC=CC5Cl

Synonyms:

• Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Ivosidenib
• (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• AG 120

RG120

CAS: 1448347-49-6

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 582.9609

Ivosidenib

CAS: 1448347-49-6

• Purity: 99.6%
• Molecular weight: 582.96g/mol

(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-Difluorocyclobutyl)Amino)-2-Oxoethyl)-1-(4-Cyanopyridin-2-Yl)-N-(5-Fluoropyridin-3-Yl)-5-Oxopyrrolidine-2-Carboxamide

CAS: 1448347-49-6

• Purity: 98%
• Molecular weight: 582.96g/mol

Ivosidenib

CAS: 1448347-49-6

• Purity: 99.78%
• Molecular weight: 582.97

Ivosidenib

CAS: 1448347-49-6

Ivosidenib (AG-120) is an oral IDH1 inhibitor targeting mutated IDH1 to reduce 2-hydroxyglutarate and hinder …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: 100% - 99.7%
• Color and Shape: Solid
• Molecular weight: 582.96

Ivosidenib

CAS: 1448347-49-6

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Molecular weight: 582.97

Ivosidenib

CAS: 1448347-49-6

Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Color and Shape: Neat
• Molecular weight: 582.96

AG 120

CAS: 1448347-49-6

Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes …

• Formula: C₂₈H₂₂ClF₃N₆O₃
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 582.96 g/mol