CAS 1448347-49-6

Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

Description:

Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-, with CAS number 1448347-49-6, is a complex organic compound characterized by its multi-functional structure. It features a glycinamide backbone, which is a derivative of glycine, and incorporates various substituents that enhance its biological activity. The presence of a cyano group and multiple aromatic rings, including pyridine and chlorophenyl moieties, suggests potential interactions with biological targets, making it of interest in medicinal chemistry. The difluorocyclobutyl group may contribute to its lipophilicity and overall pharmacokinetic properties. Additionally, the compound's stereochemistry, indicated by the (2S) designation, is crucial for its biological activity, as stereoisomers can exhibit significantly different effects in biological systems. Overall, this compound's unique structural features may position it as a candidate for further research in drug development, particularly in areas targeting specific receptors or enzymes.

Formula: C₂₈H₂₂ClF₃N₆O₃

InChI: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

InChI key: InChIKey=WIJZXSAJMHAVGX-DHLKQENFSA-N

SMILES: N([C@H](C(NC1CC(F)(F)C1)=O)C2=C(Cl)C=CC=C2)(C(=O)[C@H]3N(C(=O)CC3)C4=CC(C#N)=CC=N4)C=5C=C(F)C=NC5

Synonyms:

• Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Ivosidenib
• (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• AG 120

RG120

CAS: 1448347-49-6

Formula: C₂₈H₂₂ClF₃N₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 582.9609

Ref: IN-DA00ABO3

Ivosidenib

CAS: 1448347-49-6

Ivosidenib

Purity: ≥98%

Molecular weight: 582.96g/mol

Ref: 54-BUP16957

(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-Difluorocyclobutyl)Amino)-2-Oxoethyl)-1-(4-Cyanopyridin-2-Yl)-N-(5-Fluoropyridin-3-Yl)-5-Oxopyrrolidine-2-Carboxamide

CAS: 1448347-49-6

(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-Difluorocyclobutyl)Amino)-2-Oxoethyl)-1-(4-Cyanopyridin-2-Yl)-N-(5-Fluoropyridin-3-Yl)-5-Oxopyrrolidine-2-Carboxamide

Purity: 98%

Molecular weight: 582.96g/mol

Ref: 54-PC108973

Ivosidenib

CAS: 1448347-49-6

Purity: 99.78%

Molecular weight: 582.97

Ref: 10-F978977

Ivosidenib

CAS: 1448347-49-6

Ivosidenib (AG-120) is an oral IDH1 inhibitor targeting mutated IDH1 to reduce 2-hydroxyglutarate and hinder tumor growth.

Formula: C₂₈H₂₂ClF₃N₆O₃

Purity: 98.71% - 99.98%

Color and Shape: Solid

Molecular weight: 582.96

Ref: TM-T3617

Ivosidenib

CAS: 1448347-49-6

Formula: C₂₈H₂₂ClF₃N₆O₃

Molecular weight: 582.97

Ref: 4Z-I-165001

AG 120

CAS: 1448347-49-6

Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes impaired cellular differentiation via epigenetic modulation. By inhibiting mutant IDH1, synthesis of oncometabolite 2-hydroxyglutarate is reduced. This compound therefore has therapeutic potential in solid and haematological malignancies, such as acute myeloid leukemia (AML).

Formula: C₂₈H₂₂ClF₃N₆O₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 582.96 g/mol

Ref: 3D-FA145491

Ivosidenib

Controlled Product

CAS: 1448347-49-6

Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.
References Popovici-Muller, J., et al.: ACS Medicinal Chemistry Letters, 9, 300 (2018);

Formula: C₂₈H₂₂ClF₃N₆O₃

Color and Shape: Neat

Molecular weight: 582.96

Ref: TR-I940940