CAS 1448347-49-6
:Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
Description:
Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-, with CAS number 1448347-49-6, is a complex organic compound characterized by its multi-functional structure. It features a glycinamide backbone, which is a derivative of glycine, and incorporates various substituents that enhance its biological activity. The presence of a cyano group and multiple aromatic rings, including pyridine and chlorophenyl moieties, suggests potential interactions with biological targets, making it of interest in medicinal chemistry. The difluorocyclobutyl group may contribute to its lipophilicity and overall pharmacokinetic properties. Additionally, the compound's stereochemistry, indicated by the (2S) designation, is crucial for its biological activity, as stereoisomers can exhibit significantly different effects in biological systems. Overall, this compound's unique structural features may position it as a candidate for further research in drug development, particularly in areas targeting specific receptors or enzymes.
Formula:C28H22ClF3N6O3
InChI:InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1
InChI key:InChIKey=WIJZXSAJMHAVGX-DHLKQENFSA-N
SMILES:N([C@H](C(NC1CC(F)(F)C1)=O)C2=C(Cl)C=CC=C2)(C(=O)[C@H]3N(C(=O)CC3)C4=CC(C#N)=CC=N4)C=5C=C(F)C=NC5
Synonyms:- Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
- Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
- Ivosidenib
- (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
- AG 120
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Found 10 products.
(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-Difluorocyclobutyl)Amino)-2-Oxoethyl)-1-(4-Cyanopyridin-2-Yl)-N-(5-Fluoropyridin-3-Yl)-5-Oxopyrrolidine-2-Carboxamide
CAS:(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-Difluorocyclobutyl)Amino)-2-Oxoethyl)-1-(4-Cyanopyridin-2-Yl)-N-(5-Fluoropyridin-3-Yl)-5-Oxopyrrolidine-2-CarboxamideFormula:C28H22ClF3N6O3Purity:98%Molecular weight:582.96Ivosidenib
CAS:Ivosidenib (AG-120) is an oral IDH1 inhibitor targeting mutated IDH1 to reduce 2-hydroxyglutarate and hinder tumor growth.Formula:C28H22ClF3N6O3Purity:98.71% - 99.98%Color and Shape:SolidMolecular weight:582.96Ivosidenib
CAS:(S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamideFormula:C28H22ClF3N6O3Purity:98%Molecular weight:582.96AG 120
CAS:Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes impaired cellular differentiation via epigenetic modulation. By inhibiting mutant IDH1, synthesis of oncometabolite 2-hydroxyglutarate is reduced. This compound therefore has therapeutic potential in solid and haematological malignancies, such as acute myeloid leukemia (AML).
Formula:C28H22ClF3N6O3Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:582.96 g/molIvosidenib
CAS:Controlled ProductApplications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.
References Popovici-Muller, J., et al.: ACS Medicinal Chemistry Letters, 9, 300 (2018);Formula:C28H22ClF3N6O3Color and Shape:NeatMolecular weight:582.96
