CAS 1492-18-8: Calcium folinate

Description: Calcium folinate, also known as leucovorin or citrovorum factor, is a calcium salt of folinic acid, which is a derivative of folic acid. It is commonly used in medical applications, particularly as a medication to reduce the toxic effects of certain chemotherapy agents, such as methotrexate, by providing a source of reduced folate. This compound is characterized by its white to pale yellow crystalline appearance and is soluble in water, making it suitable for intravenous or oral administration. Calcium folinate plays a crucial role in cellular metabolism, particularly in the synthesis of nucleic acids and amino acids, which are essential for cell division and growth. Its mechanism of action involves the conversion to active forms of folate, which can bypass the metabolic block caused by antifolate drugs. Additionally, it is utilized in the treatment of megaloblastic anemia and as a supportive therapy in various cancer treatments. Safety and efficacy profiles are well-established, but it should be used under medical supervision due to potential interactions with other medications.

Formula: C₂₀H₂₃N₇O₇·Ca

InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1

InChI key: InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

SMILES: [Ca].O=CN1C=2C(=O)N=C(N)NC2NCC1CNC3=CC=C(C=C3)C(=O)NC(C(=O)O)CCC(=O)O

Synonyms:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Calcium 5-formyltetrahydrofolate
• Calcium <span class="text-smallcaps">L</span>-folinate
• Calcium Folinate
• Calcium Folinate(Folinic Acid)(Rg)
• Calcium L-Folinate
• Calcium leucovorin
• Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
• Calciumfolinat
• Folidan
• Folinate De Calcium
• Folinate-SF calcium
• Folinato Calcico
• Folinic acid Calcium salt
• Folinic acid calcium salt USP28
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
• L-Calcium Folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Lederfoline
• Leucovorin Calcium
• Leucovorin calcium salt
• LeucovorinCalcium
• Leucovorine calcium
• Nsc 3590
• Rescuvolin
• Wellcovorin
• calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate
• calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate

Folinic acid calcium salt hydrate, 98%

CAS: 1492-18-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: 98%
• Molecular weight: 511.51

Calcium folinate (Leucovorin calcium) RS

CAS: 1492-18-8

• Formula: C₂₀H₂₁CaN₇O₇
• Molecular weight: 511.5014

Calcium folinate CRS

CAS: 1492-18-8

Calcium folinate for system suitability CRS

CAS: 1492-18-8

Calcium folinate

CAS: 1492-18-8

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: 75.0%
• Color and Shape: Light Yellow
• Molecular weight: 511.11284

Leucovorin Calcium

CAS: 1492-18-8

Other vitamins and their derivatives, nesoi

• Formula: C₂₀H₂₃N₇O₇·Ca
• Color and Shape: Yellow Powder
• Molecular weight: 513.12849

Folinic acid calcium

CAS: 1492-18-8

Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used …

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: 100% - 99.5%
• Color and Shape: Yellow Crystalline Powder
• Molecular weight: 511.51

L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)

CAS: 1492-18-8

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 511.5014399999998

Folinic acid calcium salt hydrate

CAS: 1492-18-8

• Formula: C₂₀H₂₁CaN₇O₇·xH₂O
• Purity: 97.5 - 102.5 % (anhydrous basis)
• Color and Shape: Light-yellow to yellow-orange powder
• Molecular weight: 511.51 (anhydrous)

Calcium Folinate (Folic Acid USP Related Compound A, Leucovorin Calcium)

CAS: 1492-18-8

• Formula: C₂₀H₂₁N₇O₇·Ca
• Molecular weight: 471.43 40.08

Folinic acid calcium salt hydrate, USP grade

CAS: 1492-18-8

• Formula: C₂₀H₂₁CaN₇O₇·xH₂O
• Purity: (HPLC) 95.0 - 105.0 % (anhydrous substance)
• Color and Shape: Yellow-white to yellow powder
• Molecular weight: 511.50 (anhydrous)

Calcium Folinate

CAS: 1492-18-8

• Formula: C₂₀H₂₁N₇O₇·Ca
• Color and Shape: Neat
• Molecular weight: 511.50

Calcium Folinate

CAS: 1492-18-82060570-47-8 58-05-9 6035-45-6

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: >98.0%(T)(HPLC)
• Color and Shape: Light orange to Yellow to Green powder to crystaline
• Molecular weight: 511.51

Folinate calcium

CAS: 1492-18-8

• Formula: C₂₀H₂₁N₇O₇·Ca
• Color and Shape: Neat
• Molecular weight: 511.50

Folinate calcium 100 µg/mL in Water

CAS: 1492-18-8

• Formula: C₂₀H₂₁N₇O₇·Ca
• Color and Shape: Colourless
• Molecular weight: 511.50

Folinic acid calcium salt

CAS: 1492-18-8

• Purity: >97.5%
• Color and Shape: Powder
• Molecular weight: 511.50g/mol

Calcium Folinate RS

CAS: 1492-18-8

• Color and Shape: White To Light Yellow Solid Crystalline Powder

Folinic Acid Calcium Salt

CAS: 1492-18-8

Stability Hygroscopic Applications Folinic Acid Calcium Salt is a derivative of Folic Acid (F680300), a …

• Formula: C₂₀H₂₁N₇O₇·Ca
• Color and Shape: Light Yellow
• Molecular weight: 511.50

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt

CAS: 1492-18-8

• Purity: 97.0%
• Color and Shape: Solid, Slightly pale yellow - Yellow powder
• Molecular weight: 511.50799560546875

Calcium folinate

CAS: 1492-18-8

Dihydrofolate reductase activator; decreases methotrexate toxicity

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 511.50 g/mol