CAS 1492-18-8
:Calcium folinate
Description:
Calcium folinate, also known as leucovorin or citrovorum factor, is a calcium salt of folinic acid, which is a derivative of folic acid. It is commonly used in medical applications, particularly as a medication to reduce the toxic effects of certain chemotherapy agents, such as methotrexate, by providing a source of reduced folate. This compound is characterized by its white to pale yellow crystalline appearance and is soluble in water, making it suitable for intravenous or oral administration. Calcium folinate plays a crucial role in cellular metabolism, particularly in the synthesis of nucleic acids and amino acids, which are essential for cell division and growth. Its mechanism of action involves the conversion to active forms of folate, which can bypass the metabolic block caused by antifolate drugs. Additionally, it is utilized in the treatment of megaloblastic anemia and as a supportive therapy in various cancer treatments. Safety and efficacy profiles are well-established, but it should be used under medical supervision due to potential interactions with other medications.
Formula:C20H23N7O7·Ca
InChI:InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1
InChI key:InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N
SMILES:C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O.[Ca]
Synonyms:- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
- Calcium 5-formyltetrahydrofolate
- Calcium <span class="text-smallcaps">L</span>-folinate
- Calcium Folinate
- Calcium Folinate(Folinic Acid)(Rg)
- Calcium L-Folinate
- Calcium leucovorin
- Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
- Calciumfolinat
- Folidan
- Folinate De Calcium
- Folinate-SF calcium
- Folinato Calcico
- Folinic acid Calcium salt
- Folinic acid calcium salt USP28
- Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
- Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
- L-Calcium Folinate
- L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
- Lederfoline
- Leucovorin Calcium
- Leucovorin calcium salt
- LeucovorinCalcium
- Leucovorine calcium
- Nsc 3590
- Rescuvolin
- Wellcovorin
- calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate
- See more synonyms
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Calcium Folinate
CAS:Formula:C20H21CaN7O7Purity:>98.0%(T)(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalineMolecular weight:511.51Folinic acid calcium salt hydrate, 98%
CAS:<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>Formula:C20H21CaN7O7Purity:98%Molecular weight:511.51CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS
CAS:<p>CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS</p>Formula:C20H21CaN7O7Molecular weight:511.5014Calcium folinate
CAS:Calcium folinateFormula:C20H21CaN7O7Purity:75.0%Color and Shape:Light YellowMolecular weight:511.11284Leucovorin Calcium
CAS:Other vitamins and their derivatives, nesoiFormula:C20H21CaN7O7Color and Shape:Yellow PowderMolecular weight:511.11284L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
CAS:Formula:C20H21CaN7O7Purity:95%Color and Shape:SolidMolecular weight:511.5014Folinic acid calcium
CAS:<p>Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.</p>Formula:C20H21CaN7O7Purity:98.72% - >99.99%Color and Shape:Yellow Crystalline PowderMolecular weight:511.51Folinic acid calcium salt
CAS:<p>Folinic acid calcium salt</p>Purity:98%Color and Shape:PowderMolecular weight:511.50143g/molFolinic acid calcium salt hydrate
CAS:Formula:C20H21CaN7O7·xH2OPurity:97.5 - 102.5 % (anhydrous basis)Color and Shape:Light-yellow to yellow-orange powderMolecular weight:511.51 (anhydrous)Folinic acid calcium salt hydrate, USP grade
CAS:Formula:C20H21CaN7O7·xH2OPurity:(HPLC) 95.0 - 105.0 % (anhydrous substance)Color and Shape:Yellow-white to yellow powderMolecular weight:511.50 (anhydrous)Folinic Acid Calcium Salt ((6RS)-Calcium Levofolinate EP Impurity H Calcium Salt, Leucovorin Calcium Salt)
CAS:Formula:C20H21N7O7·CaMolecular weight:471.43 40.08Folinate calcium 100 µg/mL in Water
CAS:Formula:C20H21N7O7·CaColor and Shape:Single SolutionMolecular weight:511.50Folinate calcium
CAS:Controlled ProductFormula:C20H21N7O7·CaColor and Shape:NeatMolecular weight:511.50Folinic Acid Calcium Salt
CAS:<p>Stability Hygroscopic<br>Applications Folinic Acid Calcium Salt is a derivative of Folic Acid (F680300), a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).<br>References Frye, R. et al.: Mol. Psych., 18, 369 (2013); Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formula:C20H21N7O7·CaColor and Shape:Light YellowMolecular weight:511.50Calcium folinate
CAS:<p>Dihydrofolate reductase activator; decreases methotrexate toxicity</p>Formula:C20H21CaN7O7Purity:Min. 95%Color and Shape:PowderMolecular weight:511.50 g/molLeucovorin calcium salt - Bio-X ™
CAS:<p>Leucovorin is a folate analog drug that is used to treat the toxic effects of methotrexate and other antagonists of folate. It works by counteracting the toxic effects of methrotrexate by inhibiting the enzyme dihydrofolate reductase. It is used to increase the levels of folic acid and by strengthening the link between the active metabolite (5-FdUMP) and the enzyme thymidylate synthetase, leucovorin increases the action of fluorouracil. Additionally, in order to increase survival in patients undergoing palliative treatment for colorectal cancer, it is used in conjunction with 5-fluorouracil.</p>Formula:C20H23N7O7·CaPurity:Min. 95%Color and Shape:PowderMolecular weight:513.52 g/mol
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