CAS 150810-68-7

6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER

Description:

6-Carboxytetramethylrhodamine N-hydroxysuccinimide ester (CAS 150810-68-7) is a fluorescent dye commonly used in bioconjugation applications, particularly in labeling biomolecules such as proteins and nucleic acids. This compound features a rhodamine core, which is known for its strong fluorescence properties, making it suitable for various imaging techniques. The presence of a carboxyl group allows for the formation of stable amide bonds with primary amines, facilitating the conjugation process. The N-hydroxysuccinimide (NHS) ester moiety enhances the reactivity of the carboxylic acid, promoting efficient coupling to amine-containing molecules. This dye is characterized by its high quantum yield and photostability, which are essential for reliable fluorescence applications. Additionally, it is soluble in common organic solvents and aqueous buffers, making it versatile for laboratory use. Overall, 6-carboxytetramethylrhodamine NHS ester is a valuable tool in molecular biology and biochemistry for visualizing and tracking biomolecules in various experimental settings.

Formula: C₂₉H₂₅N₃O₇

InChI: InChI=1/C29H25N3O7/c1-30(2)17-6-9-20-23(14-17)38-24-15-18(31(3)4)7-10-21(24)27(20)19-8-5-16(13-22(19)28(35)36)29(37)39-32-25(33)11-12-26(32)34/h5-10,13-15H,11-12H2,1-4H3

SMILES: CN(C)c1ccc2c(c1)[o+]c1cc(ccc1c2c1ccc(cc1C(=O)[O-])C(=O)ON1C(=O)CCC1=O)N(C)C

Synonyms:

• Xanthylium, 9-2-carboxy-4-(2,5-dioxo-1-pyrrolidinyl)oxycarbonylphenyl-3,6-bis(dimethylamino)-, inner salt
• 5-Carboxytetramethylrhodamine
• 5-Tamra,Se
• 2-[6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl]-5-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}benzoate
• 5-Carboxytetramethylrhodamine succinimidyl ester
• 5-TAMRA, SE [5-Carboxytetramethylrhodamine, succinimidyl ester] *Single isomer*
• 5-TAMRA-SEor5-TAMRA-NHS
• 2-(3,6-Bis(dimethylamino)xanthylium-9-yl)-5-(((2,5-dioxopyrrolidin-1-yl)oxy)carbonyl)benzoate
• CS-2126
• "4-Carboxytetramethylrhodamine N-succinimidyl ester"
• 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER
• 5-TAMRASE
• 5-TAMRA, SE [5-Carboxytetramethylrhodamine, succinimidyl ester] *CAS#: 150810-68-7*
• 5-TAMRA N-succinimidyl ester (5-Carboxy-tetramethylrhodamine N-succinimidyl ester)
• 5-TAMRA,SE, >95%

5-TAMRA SE

CAS: 150810-68-7

Formula: C₂₉H₂₅N₃O₇

Purity: >90.0%(HPLC)

Color and Shape: Purple to Dark purple to Brown powder to crystal

Molecular weight: 527.53

Ref: 3B-T2808

5-TAMRA-SE

CAS: 150810-68-7

5-TAMRA-SE binds amines, gives stable orange-red fluorescence, exc/em ~546/579nm, pH-insensitive.

Formula: C₂₉H₂₅N₃O₇

Purity: 97.96%

Color and Shape: Solid

Molecular weight: 527.53

Ref: TM-T14054

5-Carboxytetramethylrhodamine succinimidyl ester

CAS: 150810-68-7

Formula: C₂₉H₂₅N₃O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 527.5247

Ref: IN-DA001MVZ

5(6)-Carboxytetramethylrhodamine N-hydroxysuccinimide ester

CAS: 150810-68-7

5(6)-Carboxytetramethylrhodamine N-hydroxysuccinimide ester

Formula: C₂₉H₂₅N₃O₇

Molecular weight: 527.52469

Ref: 54-BIC1061

5-TAMRA-SE

CAS: 150810-68-7

5-TAMRA-SE

Formula: C₂₉H₂₅N₃O₇

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 527.53

Ref: 54-BUP10245

5-TAMRA N-succinimidyl ester

CAS: 150810-68-7

Ref: 7W-GW5614

5-Carboxytetramethylrhodamine succinimidyl ester

CAS: 150810-68-7

5-Carboxytetramethylrhodamine succinimidyl ester is a widely employed fluorescent dye (orange/red) that is suitable for different uses. In PCR applications, it has been used as both a reporter at the 5’ or as a quencher at the 3’ end. TAMRA-labelled oligonucleotides have been used to study interactions with DNA or DNA/protein interactions. It is an excellent fluorescent acceptor for FRET applications with a suitable dye pair. It is used as a protein/antibody labelling agent for structural studies, immunochemistry and flow cytometry. Bioconjugation is generally performed through coupling of the carboxylic acid to a primary amine at the N-terminus of a protein, on lysine side chains or amino-modified oligonucleotide. Carboxylic acids that are activated with succinimidyl esters react with primary amines.

Formula: C₂₉H₂₅N₃O₇

Purity: Min. 95 Area-%

Color and Shape: Red Powder

Molecular weight: 527.52 g/mol

Ref: 3D-FC45651

5-TAMRA-SE

CAS: 150810-68-7

Purity: 98%

Molecular weight: 527.17

Ref: 10-F567301