CAS 154361-50-9
:Capecitabine
Description:
Capecitabine is an oral chemotherapeutic agent primarily used in the treatment of various cancers, including colorectal and breast cancer. It is a prodrug, meaning it is metabolized in the body to its active form, 5-fluorouracil (5-FU), which interferes with DNA synthesis and inhibits tumor growth. Capecitabine is characterized by its ability to selectively target cancer cells, which enhances its efficacy while minimizing damage to normal tissues. The compound is typically administered in a tablet form and is known for its favorable pharmacokinetic profile, allowing for convenient dosing schedules. Its mechanism of action involves the inhibition of thymidylate synthase, an enzyme critical for DNA replication. Capecitabine is generally well-tolerated, but it can cause side effects such as gastrointestinal disturbances, hand-foot syndrome, and myelosuppression. The drug's effectiveness can be influenced by genetic factors, particularly variations in enzymes involved in its metabolism, making pharmacogenomic testing relevant in some cases. Overall, capecitabine represents a significant advancement in targeted cancer therapy.
Formula:C15H22FN3O6
InChI:InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
InChI key:InChIKey=GAGWJHPBXLXJQN-UORFTKCHSA-N
SMILES:O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(OCCCCC)=O)C(F)=C2
Synonyms:- 1-(5-deoxypentofuranosyl)-5-fluoro-4-{[(pentyloxy)carbonyl]amino}pyrimidin-2(1H)-one
- 5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
- 5′-Deoxy-5-fluoro-N<sup>4</sup>-(pentyloxycarbonyl)cytidine
- Capacetrine
- Capecitabine Accord
- Capecitabine Medac
- Capecitabine SUN
- Capecitabine Teva
- Capecitibine
- Capecytabine
- Capiibine
- Captabin
- Carbamic acid, [1-(5-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-, pentyl ester
- Cytidine, 5′-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-
- Ecansya
- N4-[(pentyloxy)carbonyl]-5'-deoxy-5-fluorocytidine
- N<sup>4</sup>-Pentyloxycarbonyl-5′-deoxy-5-fluorocytidine
- Pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate
- R-340
- Ro 09-1978/000
- Ro-09-1978
- Xeloda
- Xeltabin
- Carbamic acid, [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-, pentyl ester
- See more synonyms
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Capecitabine
CAS:Formula:C15H22FN3O6Purity:>98.0%(HPLC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:359.35Capecitabine
CAS:CapecitabineFormula:C15H22FN3O6Purity:99.9%Color and Shape:White. To. Off-WhiteMolecular weight:359.14926CAPECITABINE CRS
CAS:CAPECITABINE CRSFormula:C15H22FN3O6Color and Shape:AddedMolecular weight:359.3501Capecitabine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C15H22FN3O6Color and Shape:White Off-White PowderMolecular weight:359.35Capecitabine
CAS:Capecitabine is a prodrug in the antimetabolite class, transformed into cytotoxic 5-FU by tumor cells, inhibiting DNA and RNA synthesis.Formula:C15H22FN3O6Purity:99.81% - >99.99%Color and Shape:White SolidMolecular weight:359.35Capecitabine, EP grade
CAS:Formula:C15H22FN3O6Purity:98.0 - 102.0 % (anhydrous substance)Color and Shape:White or almost white powderMolecular weight:359.35Capecitabine
CAS:Formula:C15H22FN3O6Purity:98.0 - 102.0 % (dried basis)Color and Shape:White to off-white powderMolecular weight:359.355'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
CAS:Formula:C15H22FN3O6Purity:98%Color and Shape:SolidMolecular weight:359.3501Capecitabine (Standard)
CAS:Capecitabine (Standard) is a reference standard for research and analysis in studies involving Capecitabine. Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.Formula:C15H22FN3O6Molecular weight:359.35Capecitabine
CAS:Controlled ProductApplications Capecitabine is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).
References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),Formula:C15H22FN3O6Color and Shape:NeatMolecular weight:359.35Capecitabine
CAS:Pro-drug of 5-FU; anti-cancer agent
Formula:C15H22FN3O6Purity:Min. 95%Color and Shape:PowderMolecular weight:359.35 g/molCapecitabine - Bio-X ™
CAS:Capecitabine is a chemotherapeutic agent that is used in the treatment of various cancers such as gastrointestinal, breast and pancreatic. This drug is a nucleotide metabolic inhibitor and inhibits DNA synthesis and slows the growth of tumor tissue. It is a prodrug of Fluorouracil.
Formula:C15H22FN3O6Purity:Min. 95%Color and Shape:PowderMolecular weight:359.35 g/molCapecitabine
CAS:Pentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamateFormula:C15H22FN3O6Purity:98%Molecular weight:359.35
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