CAS 156053-89-3: Alvimopan
Description:Alvimopan is a selective antagonist of the mu-opioid receptor, primarily used in the medical field to manage postoperative ileus, a condition characterized by a temporary cessation of bowel activity following surgery. It works by blocking the effects of opioids on the gastrointestinal tract, thereby promoting bowel motility without affecting analgesia provided by opioids in the central nervous system. Alvimopan is administered orally and is notable for its limited systemic absorption, which minimizes central side effects. The substance has a molecular formula that reflects its complex structure, and it is classified as a small molecule drug. Its pharmacokinetics indicate a rapid absorption and a relatively short half-life, necessitating multiple doses for sustained effect. Alvimopan is typically prescribed in a hospital setting, and its use is generally restricted to specific patient populations due to potential cardiovascular risks associated with long-term use. Overall, Alvimopan represents a targeted approach to managing gastrointestinal side effects in patients receiving opioid therapy.
Formula:C25H32N2O4
InChI:InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
InChI key:InChIKey=UPNUIXSCZBYVBB-JVFUWBCBSA-N
SMILES:O=C(O)CNC(=O)C(CC=1C=CC=CC1)CN2CCC(C=3C=CC=C(O)C3)(C)C(C)C2
- Synonyms:
- 2-([(2S)-2-([(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoyl]amino)acetic acid
- Adl 8-2698
- Entereg
- Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-
- Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, [3R-[1(S*),3α,4α]]-
- Ly 246736
- N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine
- N-{(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl}glycine
![Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenyl…](https://static.cymitquimica.com/products/IN/thumb/DA001OGS.jpg)
