CAS 156053-89-3

Alvimopan

Description:

Alvimopan is a selective antagonist of the mu-opioid receptor, primarily used in the medical field to manage postoperative ileus, a condition characterized by a temporary cessation of bowel activity following surgery. It works by blocking the effects of opioids on the gastrointestinal tract, thereby promoting bowel motility without affecting analgesia provided by opioids in the central nervous system. Alvimopan is administered orally and is notable for its limited systemic absorption, which minimizes central side effects. The substance has a molecular formula that reflects its complex structure, and it is classified as a small molecule drug. Its pharmacokinetics indicate a rapid absorption and a relatively short half-life, necessitating multiple doses for sustained effect. Alvimopan is typically prescribed in a hospital setting, and its use is generally restricted to specific patient populations due to potential cardiovascular risks associated with long-term use. Overall, Alvimopan represents a targeted approach to managing gastrointestinal side effects in patients receiving opioid therapy.

Formula: C₂₅H₃₂N₂O₄

InChI: InChI=1/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1

InChI key: InChIKey=UPNUIXSCZBYVBB-JVFUWBCBSA-N

SMILES: C[C@@]1([C@@H](C)CN(C[C@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)CC1)C3=CC(O)=CC=C3

Synonyms:

• 2-([(2S)-2-([(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoyl]amino)acetic acid
• Adl 8-2698
• Entereg
• Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-
• Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, [3R-[1(S*),3α,4α]]-
• Ly 246736
• N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine
• N-{(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl}glycine
• 2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-diMethylpiperidin-1-yl)propanaMido)acetic acid
• Unii-Q153V49p3z
• Alvimopan
• Ly246736
• trans-3,4-Dimethyl-4-(3-hydroxyphenyl) piperidine
• 170098-38-1 (Dihydrate)
• AlviMopan (ADL 8-2698)
• 2-((S)-2-Benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic a

Alvimopan

CAS: 156053-89-3

Alvimopan is a potent opioid antagonist targeting gut receptors to reverse opioid effects on motility.

Formula: C₂₅H₃₂N₂O₄

Purity: 99.47% - 99.78%

Color and Shape: Solid

Molecular weight: 424.53

Ref: TM-T1242

Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-

CAS: 156053-89-3

Formula: C₂₅H₃₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 424.5326

Ref: IN-DA001OGS

Alvimopan

CAS: 156053-89-3

Formula: C₂₅H₃₂N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 424.54

Ref: 4Z-A-431

Alvimopan

CAS: 156053-89-3

Formula: C₂₅H₃₂N₂O₄

Molecular weight: 424.53

Ref: 7W-GP9856

Alvimopan

CAS: 156053-89-3

Alvimopan

Formula: C₂₅H₃₂N₂O₄

Purity: ≥98%

Molecular weight: 424.53

Ref: 54-BUP08528

Alvimopan - Bio-X ™

CAS: 156053-89-3

Alvimopan is an mu opioid antagonist that is used in the healing of the upper and lower gastrointestinal tract after surgery. This drug is used to avoid postoperative ileus. Alvimopan binds to peripheral mu-type receptors.

Formula: C₂₅H₃₂N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 424.53 g/mol

Ref: 3D-BA164152

Alvimopan

CAS: 156053-89-3

Ref: BE-RMCA145000

Alvimopan

Controlled Product

CAS: 156053-89-3

Applications A peripheral µ-opioid receptor antagonist. Gastroprokinetic.
References Zimmerman, D.M., et al.: J. Med. Chem., 37, 2262 (1994), Liu, S.S., et al.: Clin. Pharmacol. Ther., 68, 66 (2000), Taguchi, A., et al.: N. Engl. J. Med., 345, 935 (2001),

Formula: C₂₅H₃₂N₂O₄

Color and Shape: Neat

Molecular weight: 424.53

Ref: TR-A575800

Alvimopan

CAS: 156053-89-3

Formula: C₂₅H₃₂N₂O₄

Molecular weight: 424.54

Ref: ST-EA-CP-A127000

Alvimopan

CAS: 156053-89-3

Peripheral ?-opioid receptor antagonist; gastroprokinetic

Formula: C₂₅H₃₂N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 424.53 g/mol

Ref: 3D-FA17336