CAS 156897-06-2

Licofelone

Description:

Licofelone is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic and anti-inflammatory properties. It is primarily characterized by its dual mechanism of action, as it inhibits both cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, which are involved in the inflammatory process. This dual inhibition is thought to provide a broader therapeutic effect compared to traditional NSAIDs that primarily target COX enzymes. Licofelone has been investigated for its potential use in treating conditions such as osteoarthritis and rheumatoid arthritis. Its pharmacokinetic profile indicates moderate absorption and a relatively long half-life, allowing for once-daily dosing in some formulations. Additionally, Licofelone has been studied for its gastrointestinal safety profile, which may be more favorable than that of conventional NSAIDs, potentially reducing the risk of gastrointestinal side effects. However, as with any medication, the efficacy and safety profile should be evaluated in clinical settings, and it is essential to consider individual patient factors when prescribing.

Formula: C₂₃H₂₂ClNO₂

InChI: InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)

InChI key: InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N

SMILES: C(C(O)=O)C1=C(C(=C2N1CC(C)(C)C2)C3=CC=CC=C3)C4=CC=C(Cl)C=C4

Synonyms:

• 1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-
• 2-[2-(4-Chlorophenyl)-6,6-Dimethyl-1-Phenyl-5,7-Dihydropyrrolizin-3-Yl]Acetic Acid
• 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
• 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
• Licofelone, ML-3000
• Ml 3000
• [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
• [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
• Licofelone

1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

CAS: 156897-06-2

Formula: C₂₃H₂₂ClNO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 379.8793

Ref: IN-DA001P1P

Licofelone

CAS: 156897-06-2

Licofelone

Purity: ≥98%

Molecular weight: 379.88g/mol

Ref: 54-BUP13429

Licofelone

CAS: 156897-06-2

Formula: C₂₃H₂₂ClNO₂

Molecular weight: 379.88

Ref: 7W-GP1239

Licofelone

CAS: 156897-06-2

Formula: C₂₃H₂₂ClNO₂

Purity: >95.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 379.88

Ref: 3B-L0348

Licofelone

CAS: 156897-06-2

Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.

Formula: C₂₃H₂₂ClNO₂

Purity: 99.25%

Color and Shape: Yellowish Solid

Molecular weight: 379.88

Ref: TM-T6568

Licofelone

Controlled Product

CAS: 156897-06-2

Applications Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.
References Laufer, S.A., et al.: J. Med. Chem., 37, 1894 (1994), Tries, S., et al.: Inflamm. Res., 51, 135 (2002), Moreau, M., et al.: J. Vet. Pharmacol. Ther., 28, 81 (2005),

Formula: C₂₃H₂₂ClNO₂

Color and Shape: Neat

Molecular weight: 379.88

Ref: TR-L397730

Licofelone

CAS: 156897-06-2

Dual COX/5-LO inhibitor; anti-inflammatory; analgesic

Formula: C₂₃H₂₂ClNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 379.88 g/mol

Ref: 3D-FC24890