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CAS 156897-06-2

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Licofelone

Description:
Licofelone is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic and anti-inflammatory properties. It is primarily characterized by its dual mechanism of action, as it inhibits both cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, which are involved in the inflammatory process. This dual inhibition is thought to provide a broader therapeutic effect compared to traditional NSAIDs that primarily target COX enzymes. Licofelone has been investigated for its potential use in treating conditions such as osteoarthritis and rheumatoid arthritis. Its pharmacokinetic profile indicates moderate absorption and a relatively long half-life, allowing for once-daily dosing in some formulations. Additionally, Licofelone has been studied for its gastrointestinal safety profile, which may be more favorable than that of conventional NSAIDs, potentially reducing the risk of gastrointestinal side effects. However, as with any medication, the efficacy and safety profile should be evaluated in clinical settings, and it is essential to consider individual patient factors when prescribing.
Formula:C23H22ClNO2
InChI:InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
InChI key:InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N
SMILES:C(C(O)=O)C1=C(C(=C2N1CC(C)(C)C2)C3=CC=CC=C3)C4=CC=C(Cl)C=C4
Synonyms:
  • 1H-Pyrrolizine-5-acetic acid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-
  • 2-[2-(4-Chlorophenyl)-6,6-Dimethyl-1-Phenyl-5,7-Dihydropyrrolizin-3-Yl]Acetic Acid
  • 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
  • Licofelone, ML-3000
  • Ml 3000
  • [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • Licofelone
Found 8 products.