CAS 162401-32-3

Roflumilast

Description:

Roflumilast is a selective phosphodiesterase-4 (PDE4) inhibitor primarily used in the management of chronic obstructive pulmonary disease (COPD). It is characterized by its ability to reduce inflammation in the airways, thereby improving lung function and decreasing the frequency of exacerbations. The chemical structure of Roflumilast includes a pyridine ring and a substituted amide, contributing to its pharmacological activity. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Roflumilast is known to have a favorable safety profile, although it may cause gastrointestinal side effects and has been associated with weight loss in some patients. Its mechanism of action involves the inhibition of the breakdown of cyclic adenosine monophosphate (cAMP), leading to increased levels of cAMP in inflammatory cells, which helps to modulate the inflammatory response. Overall, Roflumilast represents an important therapeutic option for patients with COPD, particularly those with a history of frequent exacerbations.

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

InChI: InChI=1/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChI key: InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N

SMILES: O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2

Synonyms:

• 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
• 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
• Arq 151
• B 9302-107
• Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
• By 217
• Byk 20869
• Daliresp
• Daxas
• Libertek
• N-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
• Roflumilast

Roflumilast

CAS: 162401-32-3

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 403.21

Ref: 3B-R0193

Roflumilast

CAS: 162401-32-3

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Color and Shape: White Powder

Molecular weight: 402.03495

Ref: 45-1605012

Roflumilast

CAS: 162401-32-3

Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: 99.76% - 99.86%

Color and Shape: Solid

Molecular weight: 403.21

Ref: TM-T1024

Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-

CAS: 162401-32-3

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 403.2075

Ref: IN-DA001T2D

Roflumilast

CAS: 162401-32-3

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 403.22

Ref: 4Z-R-371

Roflumilast

CAS: 162401-32-3

Roflumilast

Purity: 98%

Molecular weight: 403.21g/mol

Ref: 54-PC109189

Roflumilast

CAS: 162401-32-3

Roflumilast

Purity: ≥98%

Molecular weight: 403.21g/mol

Ref: 54-BUP16988

Roflumilast

Controlled Product

CAS: 162401-32-3

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Color and Shape: Neat

Molecular weight: 403.21

Ref: 86-MM3618.00

Roflumilast

CAS: 162401-32-3

Applications Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.
References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Color and Shape: Neat

Molecular weight: 403.21

Ref: TR-R639700

Roflumilast - Bio-X ™

CAS: 162401-32-3

Roflumilast is a selective phosphodiesterase-4 inhibitor that is used for the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD). It is also used to treat plaque psoriasis. This drug has anti-inflammatory and immunomodulatory effects as it aids in increasing levels of cAMP.

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 403.21 g/mol

Ref: 3D-BR164364

3,4-Bis(difluoromethoxy) Roflumilast

Controlled Product

CAS: 162401-32-3

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Color and Shape: Neat

Molecular weight: 403.21

Ref: TR-B426280

Roflumilast

CAS: 162401-32-3

Phosphodiesterase-4 inhibitor; anti-inflammatory

Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 403.21 g/mol

Ref: 3D-FR27749