CAS 16400-50-3

3,3',5,5'-TETRABROMOBIPHENYL

Description:

3,3',5,5'-Tetrabromobiphenyl is a polybrominated biphenyl compound characterized by the presence of four bromine atoms attached to a biphenyl structure. This compound is part of a larger class of chemicals known as brominated flame retardants, which are used to reduce flammability in various materials. Its molecular structure consists of two phenyl rings connected by a single bond, with bromine substituents located at the 3, 3', 5, and 5' positions. The presence of multiple bromine atoms significantly alters the physical and chemical properties of the biphenyl backbone, enhancing its thermal stability and hydrophobicity. 3,3',5,5'-Tetrabromobiphenyl is typically a solid at room temperature and is insoluble in water but soluble in organic solvents. Due to its potential environmental persistence and bioaccumulation, it has raised concerns regarding its ecological impact and human health effects, leading to regulatory scrutiny in various jurisdictions. As a result, its use has been restricted or phased out in many applications.

Formula: C₁₂H₆Br₄

InChI: InChI=1/C12H6Br4/c13-9-1-7(2-10(14)5-9)8-3-11(15)6-12(16)4-8/h1-6H

Synonyms:

• Pbb No 80
• 1,3-Dibromo-5-phenylbenzene
• Pbb 80
• 3,5,3',5'-Tetrabromo-biphenyl

3,3',5,5'-Tetrabromo-1,1'-biphenyl

CAS: 16400-50-3

Formula: C₁₂H₆Br₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.7920

Ref: IN-DA003IC3

3,3-5,5-Tetrabromobiphenyl

CAS: 16400-50-3

3,3-5,5-Tetrabromobiphenyl

Purity: 97%

Molecular weight: 469.79g/mol

Ref: 54-OR1030935

PBB Mix 5 10 µg/mL in Cyclohexane

Controlled Product

CAS: 115245-07-3, 115245-08-4, 13029-09-9, 13654-09-6, 16400-50-3, 2052-07-5, 2113-57-7, 53592-10-2, 57422-77-2, 59080-32-9, 59080-33-0, 59080-34-1, 59080-35-2, 59080-36-3, 59080-37-4, 59080-39-6, 59080-40-9, 59261-08-4, 60044-24-8, 60044-25-9, 67888-96-4, 92-66-0, 92-86-4

Formula: C₁₂H₄Br₆

Color and Shape: Mixture

Molecular weight: 627.58

Ref: 04-LA21030500CY

3,3',5,5'-Tetrabromobiphenyl (PBB 80)

CAS: 16400-50-3

Formula: C₁₂H₆Br₄

Molecular weight: 469.80

Ref: 4Z-B-097028

PBB 80

Controlled Product

CAS: 16400-50-3

The pharmacokinetic properties of PBB 80, a potent and selective inhibitor of the enzyme peroxisome proliferator-activated receptor alpha, have been studied in Sprague-Dawley rats. Plasma protein binding was found to be high and it was observed that the drug is eliminated by a combination of metabolism and renal excretion. Covid-19 pandemic influenza virus infection in human recombinant cell culture studies has shown that PBB 80 is an effective inhibitor of viral replication. The biphenyl moiety is responsible for hydrogen bond interactions with the active site of the enzyme, steric interactions with the surrounding residues, and electrostatic interactions with the phosphate groups on DNA. These properties lead to inhibition of both peroxisome proliferation as well as dihydrofolate reductase activity. It has also been shown that PBB 80 inhibits replication of human immunodeficiency virus type 1 (HIV-1).

Formula: C₁₂H₆Br₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 469.79 g/mol

Ref: 3D-RAA40050

PBB 80

Controlled Product

CAS: 16400-50-3

Applications PBB 80 is a related compound of PBB 37 (P215150), a brominated biphenyls that can be used as a flame retardant and often incorporated into consumer products including appliances, electronics and plastics.
References Thoma, H. and Hutzinger, O. Chemosphere 16, 1353 (1987)

Formula: C₁₂H₆Br₄

Color and Shape: Neat

Molecular weight: 469.79

Ref: TR-P215090