CAS 189275-74-9

AC-WEHD-AMC

Description:

AC-WEHD-AMC, identified by its CAS number 189275-74-9, is a chemical compound that belongs to a class of substances often utilized in research and industrial applications. While specific characteristics such as its molecular structure, physical properties, and reactivity may vary, compounds of this nature typically exhibit unique functional groups that contribute to their chemical behavior. They may be involved in various applications, including but not limited to, pharmaceuticals, agrochemicals, or as intermediates in organic synthesis. The compound's solubility, stability, and interaction with other substances are crucial for determining its practical uses. Additionally, safety data sheets and regulatory information should be consulted to understand its handling, toxicity, and environmental impact. For precise applications and characteristics, further detailed studies or literature reviews would be necessary, as the information can vary based on the context of use and specific formulations.

Formula: C₃₈H₄₀N₈O₁₁

Synonyms:

• Acetyl-L-Tryptophyl-L-Glutamyl-L-Histidyl-L-Aspartic Acid Alpha-(4-Methylcoumaryl-7-Amide)
• Ac-Wehd-Mca
• Ac-Trp-Glu-His-Asp-7-Amino-4-Methylcoumarin
• Ac-Trp-Glu-His-Asp-Amc
• Ac-Trp-Glu-His-Asp-Mca
• Caspase 1 (Ice) Substrate 3M, Fluorogenic
• Caspase-1 Substrate (Fluorogenic)

Ac-Trp-Glu-His-Asp-AMC

CAS: 189275-74-9

With a kcat/Km of 3.3 · 10⁶ M⁻¹s⁻¹ the fluorogenic caspase-1 substrate Ac-WEHD-AMC is cleaved 50-fold more efficiently thanAc-YVAD-AMC. This result indicates that the optimal tetrapeptide recognition sequence for caspase-1 is Trp-Glu-His-Asp and not Tyr-Val-Ala-Asp.

Formula: C₃₈H₄₀N₈O₁₁

Purity: 96.88%

Color and Shape: White

Molecular weight: 784.78

Ref: 01-4027662

Ac-Trp-Glu-His-Asp-AMC

CAS: 189275-74-9

Ac-Trp-Glu-His-Asp-AMC is a peptide that can be used as a research tool in cell biology and pharmacology. Ac-Trp-Glu-His-Asp-AMC has been shown to inhibit ion channels, which are proteins that control the flow of ions across the cell membrane. It binds to specific receptor sites on the outside of cells, which causes conformational changes in the ion channel that prevent it from opening. Ac-Trp-Glu-His-Asp AMC has been shown to increase the intracellular concentration of calcium ions, which is necessary for muscle contraction and other cellular processes.

Formula: C₃₈H₄₀N₈O₁₁

Purity: Min. 95%

Molecular weight: 784.77 g/mol

Ref: 3D-MCA-3186-V

Ac-Trp-Glu-His-Asp-AMC

CAS: 189275-74-9

Ac-Trp-Glu-His-Asp-AMC is a monomer that is expressed by baculoviruses. Cryo-electron microscopy has shown that Ac-Trp-Glu-His-Asp-AMC oligomerizes in the presence of caspase inhibitors. This polypeptide also activates caspase 1, which is involved in the inflammatory response. The activation of this enzyme is dependent on the proteolytic activity of the polypeptide and its stereoisomers. Acetylcholine receptor antagonists, such as coumarin derivatives, inhibit the activity of Ac-Trp-Glu-His-Asp AMC and suppress inflammation.

Formula: C₃₈H₄₀N₈O₁₁

Purity: Min. 95%

Molecular weight: 784.77 g/mol

Ref: 3D-FA110576