CAS 192185-72-1: Tipifarnib

Description: Tipifarnib, with the CAS number 192185-72-1, is a synthetic organic compound classified as a farnesyltransferase inhibitor. It is primarily investigated for its potential therapeutic applications in oncology, particularly for treating certain types of cancer, including hematologic malignancies and solid tumors. The compound works by inhibiting the farnesylation process, which is crucial for the proper functioning of several oncogenic proteins, thereby disrupting cancer cell proliferation and survival. Tipifarnib is characterized by its specific molecular structure, which includes a farnesyl moiety, contributing to its mechanism of action. It is typically administered in a clinical setting and has undergone various phases of clinical trials to evaluate its efficacy and safety profile. As with many investigational drugs, its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its therapeutic potential and optimizing treatment regimens. Overall, Tipifarnib represents a targeted approach in cancer therapy, focusing on molecular pathways involved in tumor growth and progression.

Formula: C₂₇H₂₂Cl₂N₄O

InChI: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChI key: InChIKey=PLHJCIYEEKOWNM-HHHXNRCGSA-N

SMILES: O=C1C=C(C=2C=CC=C(Cl)C2)C=3C=C(C=CC3N1C)C(N)(C4=CC=C(Cl)C=C4)C5=CN=CN5C

Synonyms:

• (R)-(+)-R 115777
• (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
• 2(1H)-Quinolinone, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
• 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
• 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
• Tipifarnib Zarnestra
• Zarnestra
• Tipifarnib

2(1H)-Quinolinone, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-

CAS: 192185-72-1

• Formula: C₂₇H₂₂Cl₂N₄O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 489.3958

Tipifarnib

CAS: 192185-72-1

• Purity: 99.21%
• Molecular weight: 489.4g/mol

Tipifarnib

CAS: 192185-72-1

Tipifarnib

CAS: 192185-72-1

• Formula: C₂₇H₂₂Cl₂N₄O
• Purity: >95.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 489.40

Tipifarnib

CAS: 192185-72-1

• Formula: H₂
• Purity: >98%
• Color and Shape: white solid
• Molecular weight: 489.40g/mol

Tipifarnib

CAS: 192185-72-1

Tipifarnib (IND 58359), a quinolinone, inhibits farnesyl transferase, blocks Ras activation, arrests cell growth, and …

• Formula: C₂₇H₂₂Cl₂N₄O
• Purity: 97.1% - 99.22%
• Color and Shape: Off-White To Pale Beige Solid
• Molecular weight: 489.4

Tipifarnib

CAS: 192185-72-1

Applications A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation …

• Formula: C₂₇H₂₂Cl₂N₄O
• Color and Shape: Neat
• Molecular weight: 489.40

Tipifarnib

CAS: 192185-72-1

Please enquire for more information about Tipifarnib including the price, delivery time and more detailed …

• Formula: C₂₇H₂₂Cl₂N₄O
• Purity: Min. 95%
• Molecular weight: 489.4 g/mol