CAS 192185-72-1

Tipifarnib

Description:

Tipifarnib, with the CAS number 192185-72-1, is a synthetic organic compound classified as a farnesyltransferase inhibitor. It is primarily investigated for its potential therapeutic applications in oncology, particularly for treating certain types of cancer, including hematologic malignancies and solid tumors. The compound works by inhibiting the farnesylation process, which is crucial for the proper functioning of several oncogenic proteins, thereby disrupting cancer cell proliferation and survival. Tipifarnib is characterized by its specific molecular structure, which includes a farnesyl moiety, contributing to its mechanism of action. It is typically administered in a clinical setting and has undergone various phases of clinical trials to evaluate its efficacy and safety profile. As with many investigational drugs, its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its therapeutic potential and optimizing treatment regimens. Overall, Tipifarnib represents a targeted approach in cancer therapy, focusing on molecular pathways involved in tumor growth and progression.

Formula: C₂₇H₂₂Cl₂N₄O

InChI: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChI key: InChIKey=PLHJCIYEEKOWNM-HHHXNRCGSA-N

SMILES: [C@](N)(C=1C=C2C(=CC(=O)N(C)C2=CC1)C3=CC(Cl)=CC=C3)(C=4N(C)C=NC4)C5=CC=C(Cl)C=C5

Synonyms:

• (R)-(+)-R 115777
• (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
• 2(1H)-Quinolinone, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
• 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
• 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
• Tipifarnib Zarnestra
• Zarnestra
• Tipifarnib

Tipifarnib

CAS: 192185-72-1

Formula: C₂₇H₂₂Cl₂N₄O

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 489.40

Ref: 3B-T4299

Tipifarnib

CAS: 192185-72-1

Tipifarnib

Formula: C₂₇H₂₂Cl₂N₄O

Purity: >98%

Color and Shape: White to off white Solid

Molecular weight: 489.39577

Ref: 54-BIFK0043

Tipifarnib

CAS: 192185-72-1

Tipifarnib

Formula: C₂₇H₂₂Cl₂N₄O

Purity: 99.5%

Molecular weight: 489.4

Ref: 54-BUP02088

Tipifarnib

CAS: 192185-72-1

Ref: 7W-GK7984

6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone

CAS: 192185-72-1

Formula: C₂₇H₂₂Cl₂N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 489.3958

Ref: IN-DA002FP2

Tipifarnib

Controlled Product

CAS: 192185-72-1

Applications A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).
References David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)

Formula: C₂₇H₂₂Cl₂N₄O

Color and Shape: Neat

Molecular weight: 489.4

Ref: TR-T444880

(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one

CAS: 192185-72-1

(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one

Formula: C₂₇H₂₂Cl₂N₄O

Purity: 98%

Molecular weight: 489.4

Ref: IN-DG226736

Tipifarnib

CAS: 192185-72-1

Tipifarnib is a farnesyltransferase inhibitor, which is a synthetic compound designed for experimental cancer treatment. It functions by targeting farnesyltransferase, an enzyme involved in the post-translational modification of proteins through the attachment of a farnesyl group to the protein's cysteine residue. This modification is crucial for the activity of several proteins, including those in the Ras signaling pathway, which is often dysregulated in cancer.

Formula: C₂₇H₂₂Cl₂N₄O

Purity: Min. 95%

Molecular weight: 489.4 g/mol

Ref: 3D-FT28289

Tipifarnib

CAS: 192185-72-1

Tipifarnib (IND 58359), a quinolinone, inhibits farnesyl transferase, blocks Ras activation, arrests cell growth, and curbs angiogenesis.

Formula: C₂₇H₂₂Cl₂N₄O

Purity: 97.1% - 99.94%

Color and Shape: Off-White To Pale Beige Solid

Molecular weight: 489.396

Ref: TM-T6271