CAS 195733-43-8

Atrasentan hydrochloride

Description:

Atrasentan hydrochloride is a selective endothelin receptor antagonist primarily used in the treatment of various cancers, particularly prostate cancer. It functions by blocking the action of endothelin-1, a potent vasoconstrictor that can promote tumor growth and metastasis. The substance is characterized by its hydrochloride salt form, which enhances its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. Atrasentan has a specific affinity for the endothelin A receptor, which is implicated in various pathological processes, including fibrosis and hypertension. Its chemical structure includes a complex arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its biological activity. The compound is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. As with many pharmaceuticals, potential side effects may include cardiovascular issues and liver function alterations, necessitating careful monitoring during treatment. Overall, Atrasentan hydrochloride represents a targeted therapeutic approach in oncology, aiming to mitigate the effects of endothelin signaling in cancer progression.

Formula: C₂₉H₃₈N₂O₆HCl

InChI: InChI=1/C29H38N2O6.ClH/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20;/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34);1H/t23-,27-,28+;/m1./s1

Synonyms:

• (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride

3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-

CAS: 195733-43-8

Formula: C₂₉H₃₉ClN₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 547.0828

Ref: IN-DA003876

Atrasentan hydrochloride

CAS: 195733-43-8

Atrasentan hydrochloride

Purity: ≥98%

Molecular weight: 547.08g/mol

Ref: 54-BUP05958

Atrasentan hydrochloride

CAS: 195733-43-8

Endothelin receptor antagonist

Formula: C₂₉H₃₈N₂O₆·HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 547.08 g/mol

Ref: 3D-FA64949

Atrasentan hydrochloride

CAS: 195733-43-8

Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).

Formula: C₂₉H₃₉ClN₂O₆

Purity: 99.75%

Color and Shape: Solid

Molecular weight: 547.08

Ref: TM-TQ0270