CAS 195987-41-8

(4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile

Formula: C₂₅H₂₃N₅O₂S₂

InChI: InChI=1/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1

SMILES: c1ccc(cc1)C[C@@H]1CN(Cc2cnc[nH]2)c2ccc(cc2CN1S(=O)(=O)c1cccs1)C#N

Synonyms:

• 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine
• Bms 214662
• (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

BMS-214662

CAS: 195987-41-8

BMS-214662

Formula: C₂₅H₂₃N₅O₂S₂

Purity: 99.58%

Molecular weight: 489.61

Ref: 54-OR1106694

(4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile

CAS: 195987-41-8

Formula: C₂₅H₂₃N₅O₂S₂

Purity: 99.58%

Color and Shape: Solid

Molecular weight: 489.6124

Ref: IN-DA00ABWZ

BMS 214662

Controlled Product

CAS: 195987-41-8

Applications A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.
References Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);

Formula: C₂₅H₂₃N₅O₂S₂

Color and Shape: Neat

Molecular weight: 489.61

Ref: TR-B596050

BMS 214662

CAS: 195987-41-8

BMS 214662 is a farnesyltransferase inhibitor, which is a synthetic compound with specific biochemical properties. It is derived from a series of potent farnesyltransferase inhibitors developed to interfere with prenylation, a post-translational modification critical for the function of several oncogenic proteins. The primary mode of action for BMS 214662 involves the inhibition of farnesyltransferase, an enzyme responsible for the attachment of a farnesyl group to proteins, such as the Ras oncoprotein, thereby impeding their proper localization and function within the cell.

Formula: C₂₅H₂₃N₅O₂S₂

Purity: Min. 95%

Molecular weight: 489.61 g/mol

Ref: 3D-VHA98741

BMS-214662

CAS: 195987-41-8

BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.

Formula: C₂₅H₂₃N₅O₂S₂

Purity: 99.58% - 99.58%

Color and Shape: Yellow Viscous

Molecular weight: 489.61

Ref: TM-T10567