CAS 20845-02-7

renin substrate tetradecapeptide

Description:

Renin substrate tetradecapeptide, also known as angiotensinogen, is a peptide that plays a crucial role in the renin-angiotensin system, which regulates blood pressure and fluid balance. This peptide consists of 14 amino acids and serves as the precursor to angiotensin I, which is subsequently converted to angiotensin II, a potent vasoconstrictor. The structure of renin substrate tetradecapeptide includes a specific sequence of amino acids that is recognized by the enzyme renin, which cleaves it to initiate the cascade of reactions leading to the production of angiotensin II. This peptide is primarily synthesized in the liver and released into the bloodstream, where it can be activated in response to various physiological stimuli, such as low blood pressure or low sodium levels. Its regulation is critical for maintaining cardiovascular homeostasis, and dysregulation can lead to conditions such as hypertension and heart failure. The CAS number 20845-02-7 uniquely identifies this substance in chemical databases, facilitating research and clinical applications related to cardiovascular health.

Formula: C₈₅H₁₂₃N₂₁O₂₀

Synonyms:

• Angiotensinogen (1-14)
• Renin substrate tetradecapeptide, porcine
• Porcine renin substrate tetradecapeptide
• Angiotensinogen (tetradecapeptide renin substrate), 5-L-isoleucine-

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH

CAS: 20845-02-7

Equine angiotensinogen (1-14) is readily cleaved by human kidney renin and human cathepsin D.

Formula: C₈₅H₁₂₃N₂₁O₂₀

Purity: > 99%

Color and Shape: White Lyophilisate

Molecular weight: 1759.04

Ref: 01-4007374

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH

CAS: 20845-02-7

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH is a synthetic peptide that has been shown to inhibit the production of angiotensin and angiotensinogen by interfering with the binding of its receptor. It has also been shown to inhibit the production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin 1beta (IL1β), and IL6, in human macrophages. HAVY can also inhibit toll like receptor 4 mediated inflammatory responses in vivo. HAVY is an inhibitor of angiotensin II type 1 receptor activity, which may be useful in treating cardiovascular diseases such as atherosclerotic lesions, hypertension, and bowel disease.

Formula: C₈₅H₁₂₃N₂₁O₂₀

Purity: Min. 95%

Molecular weight: 1,759.02 g/mol

Ref: 3D-FA110835