CAS 215713-39-6

Breceptin

CAS: 215713-39-6

Breceptin (B 9870) serves as an antagonist and partial agonist for bradykinin B1/B2 receptors (B1/B2R). In rabbit jugular vein contraction assays, it functions as an irreversible B2R antagonist, inhibiting bradykinin-induced vasoconstriction. B-9870 exhibits partial agonist characteristics in HEK 293 cells with high rabbit B2R expression, activating ERK1/2 phosphorylation, calcium mobilization, arachidonic acid release, and receptor internalization. Breceptin is applicable in research on breast cancer and non-small cell lung cancer inhibition.

Formula: C₁₃₆H₂₀₀N₃₈O₂₈

Molecular weight: 2815.33

Ref: TM-TP4193